Lactate dehydrogenase isoenzymes

MULTIPLE FORMS OF ENZYMES: TISSUE, ONTOGENETIC, AND SPECIES SPECIFIC PATTERNS

1959 • 1,097 citations

Nature and Development of Lactic Dehydrogenases

1962 • 947 citations

Lactate Dehydrogenase Isozymes: Dissociation and Recombination of Subunits

1963 • 683 citations

Lactic Dehydrogenases: Functions of the Two Types

1964 • 538 citations

LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.

1964 • 351 citations

Separation and quantitation of lactic dehydrogenase isoenzymes by disc electrophoresis

1967 • 342 citations

LACTIC DEHYDROGENASE ISOZYMES AND THEIR DISTRIBUTION IN NORMAL TISSUES AND PLASMA AND IN DISEASE STATES*

1961 • 319 citations

Lactate Dehydrogenases in Human Testes

1963 • 318 citations

The use of Control Charts in the Clinical Laboratory*

1950 • 310 citations

Separation of Tissue and Serum Creatine Kinase Isoenzymes by Ion-Exchange Column Chromatography

1974 • 266 citations

The Electrophoretically Distinct Forms of Mammalian Lactic Dehydrogenase

1960 • 252 citations

Reduction of α-Ketobutyrate by Human Serum

1960 • 236 citations

Serum enzymes and isoenzymes in the diagnosis and differential diagnosis of myocardial ischemia and necrosis.

1980 • 229 citations

Lactate Dehydrogenase Variant from Human Blood: Evidence for Molecular Subunits

1963 • 214 citations

Localization of Lactic Acid Dehydrogenase Activity in Serum Fractions

1957 • 193 citations

Combined isoenzyme analysis in the diagnosis of myocardial injury: application of electrophoretic methods for the detection and quantitation of the creatine phosphokinase MB isoenzyme.

1972 • 192 citations

High-performance liquid chromatography of proteins

1976 • 181 citations

The Electrophoretically Distinct Forms of Mammalian Lactic Dehydrogenase

1960 • 178 citations

SERUM "α-HYDROXYBUTYRIC DEHYDROGENASE" IN MYOCARDIAL INFARCTION AND IN LIVER DISEASE

1961 • 139 citations

Isoenzymes and Myocardial Infarction

1960 • 138 citations

Hereditary deficiency of lactate dehydrogenase M-subunit

1980 • 138 citations

Diagnosis of Acute Myocardial Infarction

1975 • 130 citations

Lactic Dehydrogenase: Genetic Control in Man

1963 • 112 citations

PHYSICOCHEMICAL NATURE OF ISOZYMES*

1961 • 112 citations

THE FIFTH (ELECTROPHORETICALLY SLOWEST) SERUM LACTIC DEHYDROGENASE AS AN INDEX OF LIVER INJURY

1961 • 108 citations

The enzyme diagnosis of myocardial infarction

1975 • 98 citations

Human Erythrocyte Lactate Dehydrogenase: Four Genetically Determined Variants

1964 • 94 citations

Lactic dehydrogenase isoenzymes in myocardial infarction

1962 • 91 citations

Lactic dehydrogenase isoenzymes in blood serum after storage at different temperatures

1964 • 86 citations

Comparative study of methods for quantitation of lactate dehydrogenase isozymes

1970 • 83 citations

Lactic dehydrogenase isoenzyme determination in the diagnosis of acute myocardial infarction.

1978 • 76 citations

Rapid Electrophoretic Separation of Lactate Dehydrogenase Isoenzymes on Cellulose Acetate

1965 • 75 citations

Origin of the Lactate Dehydrogenase Isoenzyme Pattern found in the Serum of Patients having Primary Muscular Dystrophy

1962 • 73 citations

Lactate Dehydrogenase Isozymes: Lability at Low Temperature

1963 • 72 citations

Immunochemical determination of the heart isoenzyme of lactate dehydrogenase (LDH1) in human serum.

1979 • 67 citations

Isoenzymes of malic dehydrogenase, glutamic oxaloacetic transaminase and lactic dehydrogenase in serum in diseases of the liver

1967 • 67 citations

CLINICAL APPLICATIONS OF LACTATE DEHYDROGENASE ISOZYMES: ALTERATIONS IN MALIGNANCY

1968 • 66 citations

Macroamylasemia and other immunoglobulin-complexed enzyme disorders.

1980 • 66 citations

FURTHER STUDIES OF THE FRACTIONATION OF LACTIC DEHYDROGENASE OF BLOOD

1958 • 64 citations

Hereditary deficiency of subunit H of lactate dehydrogenase

1971 • 64 citations

Electrophoretic Pattern of Lactic Dehydrogenase in Carriers and Patients with Duchenne Muscular Dystrophy

1964 • 59 citations

Lupoid cirrhosis with serum lactic acid dehydrogenase linked to an γA immunoglobulin

1967 • 57 citations

The staining of lactic dehydrogenase isoenzymes after electrophoretic separation on cellulose acetate

1964 • 56 citations

ISOZYMES OF LACTIC DEHYDROGENASE; THEIR ALTERATIONS IN ARTHRITIC SYNOVIAL FLUID AND SERA*

1962 • 55 citations

Electrophoresis of lactate dehydrogenase isoenzymes.

1983 • 54 citations

Origin of Elevated Serum Enzyme Activities after Direct-Current Countershock

1969 • 53 citations

Cerebrospinal-Fluid Lactic Dehydrogenase and Its Isoenzymes in Infections of the Central Nervous System

1968 • 51 citations

On the source of lactic dehydrogenase in cerebrospinal fluid

1963 • 50 citations

Lactic dehydrogenase isoenzymes in the cerebrospinal fluid of patients with systemic cancer

1981 • 50 citations

Progressive Muskeldystrophie

1961 • 47 citations

Urinary lactic dehydrogenase isoenzyme 5 in the differential diagnosis of kidney and bladder infections

1975 • 47 citations

The significance of lactate dehydrogenase isozymes in abnormal human skeletal muscle

1964 • 43 citations

Lactate dehydrogenase (LDH)-IgG3 immunoglobulin complexes in human serum

1975 • 43 citations

Estimation of the gene frequency of lactate dehydrogenase subunit deficiencies.

1984 • 41 citations

Serum enzyme determinations in the diagnosis of acute myocardial infarction: An update

1984 • 41 citations

Thin-layer agarose electrophoresis of lactate dehydrogenase isoenzymes in serum: a note on the method of reporting and on the lactate dehydrogenase isoenzyme-1/isoenzyme-2 ratio in acute myocardial infarction.

1979 • 41 citations

Electrophoresis of serum lactic dehydrogenase

1961 • 40 citations

Electrophoresis of lactate dehydrogenase isoenzymes.

1983 • 39 citations

Enzymes of normal and malignant trophoblast: Phosphoglucose isomerase, phosphoglucomutase, hexokinase, lactate dehydrogenase, and alkaline phosphatase

1975 • 38 citations

Changes in Peripheral Serum Creatine Phosphokinase (CPK) and Lactic Dehydrogenase (LDH) in Acute Experimental Colonic Infarction

1981 • 35 citations

Lactate Dehydrogenase—6

1985 • 35 citations

Standardisation of isoenzyme assays with special reference to lactate dehydrogenase isoenzyme electrophoresis

1974 • 35 citations

Two more "private" polymorphisms of Amerindian tribes: LDHb GUA-1 and ACP1 B GUA-1 in the Guaymi in Panama.

1977 • 34 citations

Erythematosquamous Skin Lesions in Hereditary Lactate Dehydrogenase M-Subunit Deficiency

1986 • 34 citations

Enzyme-selective detector systems for high-pressure liquid chromatography

1977 • 34 citations

LDH isoenzymes in benign and malignant prostate tissue.The LDH V/I ratio as an index of malignancy

1970 • 34 citations

Simultaneous Separation of Serum Creatine Kinase and Lactate Dehydrogenase Isoenzymes by Ion-Exchange Column Chromatography

1975 • 33 citations

Comparison of Urinary Lactic Dehydrogenase with Antibody-Coated Bacteria in the Urine Sediment as Means of Localizing the Site of Urinary Tract Infection

1979 • 33 citations

Lactate dehydrogenase isoenzyme-1: changes during the first day after acute myocardial infarction.

1981 • 33 citations

Serum Total and Isoenzyme Lactate Dehydrogenase Activity in American Burkitt’s Lymphoma Patients

1982 • 32 citations

Lactic dehydrogenase isoenzyme electrophoretic patterns in the diagnosis of pleural effusion

1984 • 32 citations

LDH‐C₄ in human seminal plasma and its relationship to testicular function

1985 • 32 citations

Separation and measurement of isoenzymes and other proteins by high-performance liquid chromatography

1982 • 32 citations

CHROMATOGRAPHIC DIFFERENTIATION OF LACTATE DEHYDROGENASE OF HUMAN TISSUE AND SERUM*

1961 • 32 citations

LDH isoenzyme patterns in tumors, polyps, and uninvolved mucosa of human cancerous colon

1982 • 30 citations

High-pressure liquid-chromatographic separation of lactate dehydrogenase isoenzymes.

1976 • 29 citations

Enzyme activities and isozyme patterns in human lung tumors.

1984 • 29 citations

Analysis of serum lactic dehydrogenase levels and its isoenzymes in ovarian dysgerminoma

1985 • 28 citations

Serum lactic dehydrogenase and isoenzyme changes in clinical cancer

1973 • 27 citations

Lactate Dehydrogenase Isoenzymes in Malignant Tissues

1966 • 27 citations

Serumα-Hydroxybutyrate Dehydrogenase Activity: An Improved Method

1971 • 26 citations

Hepatitis B "e" Antigen: An Apparent Association with Lactate Dehydrogenase Isozyme-5

1977 • 26 citations

Lactic Dehydrogenase Isoenzymes in Human Bladder Cancer

1975 • 26 citations

Stability of lactate dehydrogenase at different storage temperatures

1986 • 26 citations

Changes in the ratio of lactate dehydrogenase isoenzymes 1 and 2 during the first day after acute myocardial infarction.

1985 • 25 citations

Lactate Dehydrogenase Isoenzyme Polymorphism in a Patient with Secondary Carcinoma of the Liver

1968 • 25 citations

Lactate dehydrogenase isoenzymes: Irregularities in electrophoretic mobility

1965 • 24 citations

LDHk, a uniquely regulated cryptic lactate dehydrogenase associated with transformation by the Kirsten sarcoma virus.

1981 • 24 citations

Creatine kinase and lactate dehydrogenase: stability of isoenzymes and their activity in stored human plasma and prostatic tissue extracts and effect of sample dilution.

1983 • 24 citations

Immunochemical studies on lactate dehydrogenase

1973 • 23 citations

Alterations in Serum Lactate Dehydrogenase and its Fourth and Fifth Isozymes in Patients with Prostatic Carcinoma

1965 • 23 citations

THE INFLUENCE OF CYTOSTATIC TREATMENT ON SERUM LDH PATTERNS OF PATIENTS WITH BRONCHIAL CARCINOMA AND ITS RELATION TO TUMOR REGRESSION

1968 • 23 citations

Dual-detector-post-column reactor system for the detection of isoenzymes separated by high-performance liquid chromatography

1979 • 22 citations

New developments in analysis of isoenzymes separated by "high-performance" liquid chromatography.

1979 • 22 citations

Predictive value of serum enzyme determinations in acute myocardial infarction

1980 • 21 citations

Changes in lactate dehydrogenase isoenzyme patterns in patients with tumours of the central nervous system

1977 • 21 citations

IMMUNOCHEMICAL STUDIES OF HUMAN LACTIC DEHYDROGENASES*

1963 • 21 citations

Serum Lactic Dehydrogenase Activity and Isoenzyme Patterns in Some Haematological Diseases

1965 • 20 citations

The Origin of the Elevated Serum Lactate Dehydrogenase in Megaloblastic Anaemia

1967 • 20 citations

An enzymatically inactive variant of human lactate dehydrogenase-LDHBGUA-1 Study of subunit interaction

1982 • 19 citations

Urinary lactic dehydrogenase isoenzyme IV and V in the differential diagnosis of cystitis and pyelonephritis

1978 • 19 citations

LDH isoenzyme patterns in human gastric mucosa with precancerous changes

1978 • 18 citations

Serum LD-1 activity in suspected acute myocardial infarction.

1983 • 18 citations

A human trophoblastic isozyme (lactate dehydrogenase-Z) associated with choriocarcinoma.

1980 • 18 citations

Serum lactate dehydrogenase isoenzyme- 1 in children with yolk sac tumor

1985 • 18 citations

Separation of five isoenzymes of serum lactate dehydrogenase by discontinuous gradient elution from a miniature ion-exchange column.

1979 • 17 citations

Improved column method for separating lactate dehydrogenase isoenzymes 1 and 2.

1978 • 17 citations

Immunochemical studies on lactate dehydrogenase: Preparation and characterization of anti-M lactate dehydrogenase antiserum: Development of an immunochemical assay for lactate dehydrogenase isoenzymes in human serum

1973 • 17 citations

Significance of a Sixth Lactate Dehydrogenase Isoenzyme (LDH₆)

1980 • 16 citations

Changes in the ratio of lactate dehydrogenase isoenzymes 1 and 2 during the first day after acute myocardial infarction.

1985 • 16 citations

Clinical Liquid Chromatography

1978 • 16 citations

A Rapid Electrophoretic Method for the Determination of the Isoenzymes of Serum Lactate Dehydrogenase

1966 • 16 citations

Immunochemical LD₁Assay for Myocardial Infarction

1981 • 16 citations

Diagnostic Significance of Heterogeneous Lactic Dehydrogenases in Malignant Effusions

1961 • 15 citations

Lactate dehydrogenase inhibition by immunoglobulin G in human serum.

1986 • 15 citations

LDH isoenzymes in CSF in the diagnosis of neonatal brain damage

1986 • 15 citations

Characterization of apparent lactate dehydrogenase isoenzyme 6: a lactate-independent dehydrogenase.

1984 • 14 citations

Serum lactate dehydrogenase isoenzyme pattern in neuroblastoma

1976 • 14 citations

Immunochemical properties of immunoglobulin G conjugated with lactate dehydrogenase.

1985 • 14 citations

The effect of dilution and substrate repletion on the LDH isoenzyme distribution of sera with high LDH activities

1974 • 13 citations

A study of the determination of lactic dehydrogenase isoenzymes by means of agar gel and starch-agar gel zymograms

1968 • 13 citations

Immunochemical Determination of LDH-1

1981 • 13 citations

Supernumerary lactate dehydrogenase isozymes in human gliomas

1983 • 13 citations

Activity of lactate dehydrogenase isoenzymes LD1 and LD2 in serum as determined by using an inhibitor of the M-subunit.

1985 • 12 citations

LDHk, the lactate dehydrogenase associated with transformation by the Kirsten sarcoma virus: a re-evaluation.

1983 • 12 citations

Rapid separation and continuous monitoring of enzyme activity in chromatographic column effluents

1965 • 12 citations

How accurate are lactate dehydrogenase isoenzyme estimations by the thin-layer agarose fluorescent technique?

1976 • 12 citations

A Column Chromatographic Method for the Combined Analysis of Creatine Kinase-MB(CPK-MB) and Lactate Dehydrogenase 1,2(LDH 1, 2) Isoenzymes

1976 • 12 citations

Serum activities of hydroxybutyrate dehydrogenase (HBD) and the isoenzymes of lactate dehydrogenase (LD) as an index of traumatic brain injury

1977 • 11 citations

Serum inactivator to m subunit of lactate dehydrogenase isoenzymes

1974 • 11 citations

A study of lactate dehydrogenase levels and turnover rates during postnatal development in the rat

1983 • 11 citations

Control of Fertilization by Immunization With Peptide Fragments of Sperm Specific LDH-C4

1986 • 11 citations

A case of immunoglobulin G conjugated with lactate dehydrogenase, producing both loss of enzyme activity and an abnormal isoenzyme pattern.

1986 • 11 citations

Serum lactate dehydrogenase isoenzymes: stability, clearance, and diagnostic application in hemolytic anemia.

1970 • 10 citations

Quantitation of serum lactate dehydrogenase-5 with monoclonal antibodies

1986 • 10 citations

Reliability of serum LD isoenzyme determinations in the diagnosis of myocardial infarction

1974 • 9 citations

Computer-controlled instrument system for sequential clinical chemical testing. II. Evaluation of instrumental performance.

1973 • 9 citations

Evaluation of lactate dehydrogenase isoenzyme patterns in serum of patients undergoing cardiac surgery

1978 • 9 citations

Improved column method for separating lactate dehydrogenase isoenzymes 1 and 2.

1978 • 9 citations

The quality control of serum lactate dehydrogenase isoenzyme separations using commercial quality control sera

1974 • 9 citations

An Analysis of the Isoenzymes of Creatine Phosphokinase and Lactic Dehydrogenase in the Esophagus

1981 • 9 citations

Computer-controlled automation of radioimmunoassay based on gel entrapment of antibody.

1975 • 9 citations

Prognostic value of the determination of serum lactic dehydrogenase and its isoenzymes in children with acute lymphoblastic leukaemia

1985 • 9 citations

A comparative assessment of lactate dehydrogenase isozymes, LDHk and LDH5.

1985 • 9 citations

Lactate dehydrogenase-6. A biochemical sign of serious hepatic circulatory disturbance

1985 • 8 citations

Lactate Dehydrogenase Isoenzyme Activity: Best Determined from Peak Heights or by Integration?

1973 • 8 citations

Application of an Automated Determination of Isoenzyme-5 of Lactate Dehydrogenase to the Diagnosis of Hepatic Disease

1973 • 8 citations

Staining artifacts following electrophoretic separation of LDH isozymes

1976 • 8 citations

The Effect of Quick Freezing on the Preservation of Selected Serum Enzyme Activities

1969 • 8 citations

Lactic Dehydrogenase Activity in Human Pheochromocytoma

1983 • 8 citations

Lactic dehydrogenase isoenzyme determination: Effect of incubation temperature

1965 • 8 citations

Determination of human serum lactate dehydrogenase isoenzymes by anion exchange chromatography

1983 • 8 citations

Clinical liquid chromatography

1984 • 8 citations

Spectrophotometric method for selective assay of the five isoenzymes of human lactate dehydrogenase, based on their different stabilities at alkaline pH.

1983 • 7 citations

Use of cellulose acetate gel (Cellogel) for the demonstration of lactic dehydrogenase isoenzymes.

1966 • 7 citations

Abnormal lactate dehydrogenase isoenzyme in serum and tumor tissue of a patient with neuroblastoma.

1985 • 7 citations

Increased lactate dehydrogenase in serum in measles infection.

1987 • 6 citations

Automatic analysis of serum lactate dehydrogenase isoenzymes by high-performance ion-exchange chromatography

1986 • 6 citations

Lactate dehydrogenase isoenzymes in diabetic patients.

1985 • 6 citations

Defining the locus of origin of a genetically determined electrophoretic variant of a multilocus enzyme system; the calcutta-1 of human LDH system is a B-locus variant

1981 • 6 citations

Rapid analysis of serum lactate dehydrogenase isoenzymes by high-performance ion-exchange chromatography

1986 • 6 citations

Unusual increases in serum lactate dehydrogenase isoenzyme-5 activity caused by severe congestive cardiac failure: two case reports.

1979 • 6 citations

Optimization and evaluation of cardiac enzymes and isoenzymes measured on a random access analyzer.

1985 • 6 citations

Lactate dehydrogenase isoenzyme 1 with the centrifugal analyzer after immunochemical removal of other isoenzymes.

1981 • 6 citations

Does lactate dehydrogenase isoenzyme-5 contribute to the predictive power of total lactate dehydrogenase in myocardial infarction?

1983 • 5 citations

Optimal α-Oxobutyrate Concentration for Assay of α-Hydroxybutyrate Dehydrogenase Activity in Normal and Pathological Sera at 30 °C

1974 • 5 citations

Serum lactic dehydrogenase and its isoenzymes in hepatic disorders.

1971 • 5 citations

A Versatile Temperature-Controlled Reaction Cuvet

1975 • 5 citations

Two methods compared for measuring LD-1/total LD activity in serum.

1986 • 5 citations

Lactate dehydrogenase isoenzyme-1/total ratio: accurate for determining the existence of myocardial infarction.

1986 • 4 citations

Automated kinetic assay for lactate dehydrogenase isoenzyme 1 by centrifugal analysis after alkaline inactivation.

1984 • 4 citations

Radioimmunoassay of lactate dehydrogenase, H forms

1979 • 4 citations

Does lactate dehydrogenase isoenzyme-5 contribute to the predictive power of total lactate dehydrogenase in myocardial infarction?

1983 • 4 citations

An unusual oxygen-sensitive lactate dehydrogenase isozyme associated with Kirsten murine sarcoma virus in human serum.

1984 • 4 citations

Elevation of serum lactate dehydrogenase-5 following methylglucamine iodipamide (Cholografin/Biligrafin) infusion for intravenous cholangiography

1982 • 4 citations

Lactate dehydrogenase isoenzyme 1: its usefulness as a screening test in diagnosis of myocardial infarction

1983 • 4 citations

New Laboratory Method to Detect Hepatitis‐B (Australia) Antigen Based on ‘Anomalous' Lactate Dehydrogenase Isoenzyme

1976 • 4 citations

Serum lactate dehydrogenase isoenzyme pattern in acute transformation of chronic granulocytic leukemia.

1986 • 3 citations

Evaluation of plasma lactate dehydrogenase (LDH) isozymes in cancer patients. II: qualitative and quantitative assessment in patients with oral cancers and osteosarcoma.

1977 • 3 citations

Increased Lactate Dehydrogenase Isoenzyme-5 (LD5) Activity Evidently Caused by Persistent Diaphragmatic Pressure on a Congested Liver

1973 • 3 citations

A "column-batch" method for separating MB and LD1 in a single fraction.

1983 • 3 citations

Micromethod for determination of lactate dehydrogenase isoenzyme C4 activity in human seminal plasma.

1983 • 3 citations

Bioluminescent assay of lactate dehydrogenase and its isoenzyme-1 activity.

1984 • 3 citations

Serum Lactate Dehydrogenase and Its Isozymes in Lupus Nephritis

1986 • 3 citations

Lactate dehydrogenase isoenzyme levels in collagen disease.

1977 • 3 citations

Accuracy of lactate dehydrogenase isoenzyme estimations by a thin-layer agarose fluorescent technique: experience with ternary and quaternary mixtures of purified human lactate dehydrogenase isoenzymes.

1983 • 2 citations

Detection of lactate dehydrogenase B4 in human hemolysate of patients deficient in lactate dehydrogenase B subunit activity using enzyme immunoassay

1986 • 2 citations

A comparative study of total serum LDH and its isoenzymes in cases of hepatic malignancy and cirrhosis of liver.

1978 • 2 citations

CSF LDH and its isoenzymes in tubercular and pyogenic meningitis.

1985 • 2 citations

Serum lactic dehydrogenase isoenzymes and serum hydroxy butyric dehydrogenase in myocardial infarction.

1979 • 1 citations

Automated determination of activities of lactate dehydrogenase isoenzymes LD-1 and LD-2 in serum with use of an inhibitor.

1986 • 1 citations

Laboratory and immunological assessment in lactate dehydrogenase subunit deficiency.

1987 • 1 citations

Lactate dehydrogenase isoenzymes in serum during unstable angina.

1986 • 1 citations