Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

1963 • 29,357 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.

1997 • 170 citations

In VivoAdenovirus-Mediated Gene Transfer of theEscherichia coliCytosine Deaminase Gene to Human Colon Carcinoma-Derived Tumors Induces Chemosensitivity to 5-Fluorocytosine

1995 • 165 citations

A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase.

1993 • 161 citations

Transcriptional Regulatory Sequences of Carcinoembryonic Antigen: Identification and Use with Cytosine Deaminase for Tumor-Specific Gene Therapy

1995 • 160 citations

Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase

1992 • 125 citations

Transformed cell lines susceptible or resistant to in vivo surveillance against tumorigenesis

1978 • 122 citations

5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory.

1995 • 109 citations

Metabolic suicide genes in gene therapy

1994 • 104 citations

Double Suicide Gene (Cytosine Deaminase and Herpes Simplex Virus Thymidine Kinase) but Not Single Gene Transfer Allows Reliable Elimination of Tumor CellsIn Vivo

1998 • 99 citations

Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules.

1985 • 90 citations

Regional Delivery of an Adenovirus Vector Containing the Escherichia coli Cytosine Deaminase Gene to Provide Local Activation of 5-Fluorocytosine to Suppress the Growth of Colon Carcinoma Metastatic to Liver

1996 • 80 citations

In VivoReplication-Deficient Adenovirus Vector-Mediated Transduction of the Cytosine Deaminase Gene Sensitizes Glioma Cells to 5-Fluorocytosine

1996 • 77 citations

Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates

1991 • 70 citations

Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma

1995 • 64 citations

Bystander effect caused by cytosine deaminase gene and 5-fluorocytosine in vitro is substantially mediated by generated 5-fluorouracil.

1998 • 50 citations

Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment

1998 • 47 citations

Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma

1997 • 33 citations

Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer

1996 • 22 citations

Construction of retroviral vectors to induce strong hepatoma cell‐specific expression of cytokine genes

1996 • 21 citations

Metastasis after intravenous inoculation of highly metastatic variants of mouse tumors and the effects of several antitumor drugs on the tumors.

1984 • 17 citations

Bacterial cytosine deaminase suicide gene transduction renders hepatocellular carcinoma sensitive to the prodrug 5-fluorocytosine

1995 • 10 citations