Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

1975 • 2,622 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Hepatic metastases from colorectal carcinoma: Impact of surgical resection on the natural history

1990 • 846 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

One hundred patients with hepatic metastases from colorectal cancer treated by resection: Analysis of prognostic determinants

1991 • 455 citations

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

1993 • 420 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

Clinical effects and toxicity of interleukin-2 in patients with cancer

1986 • 359 citations

In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.

1988 • 356 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

A new class of Escherichia coli recBC mutants: implications for the role of RecBC enzyme in homologous recombination.

1984 • 194 citations

Hepatic Resection of Metastasis from Colorectal Carcinoma

1989 • 170 citations

A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase.

1993 • 161 citations

Hepatic resection for secondary neoplasms.

1982 • 138 citations

Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase

1992 • 125 citations

Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.

1989 • 111 citations

Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor.

1989 • 83 citations

Immunization of Cancer Patients Using Autologous Cancer Cells Modified by Insertion of the Gene for Interleukin-2 (National Institutes of Health)

1992 • 43 citations

Purification and some properties of cytosine deaminase from Salmonella typhimurium

1982 • 31 citations

Purine and pyrimidine transport and permeation in human erythrocytes

1987 • 24 citations

Metabolism and actions of 2‐deoxy‐2‐fluoro‐<scp>d</scp>‐galactose in vivo

1990 • 21 citations

A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer

1993 • 11 citations

A phase 2 trial of recombinant interleukin-2 and 5-fluorouracil in patients with metastatic colorectal carcinoma.

1992 • 6 citations

Interleukin-2 followed by fluorouracil and folinic acid in refractory colorectal cancer--results of a clinical phase II study.

1992 • 4 citations

Regional application of cytokines: Experience with various clinical protocols

1992 • 1 citations