Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

The secret life of the hair follicle

1992 • 919 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

SH2 and SH3 domains

1993 • 697 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

1994 • 597 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

The stimulation of epidermal proliferation by a specific protein (EGF)

1965 • 421 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

1990 • 401 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function

1990 • 362 citations

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

1984 • 316 citations

The Stimulation of Epidermal Keratinization by a Protein Isolated from the Submaxillary Gland of the Mouse**From the Department of Biochemistry and the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee.

1963 • 310 citations

The secret life of the hair follicle

1992 • 243 citations

Growth modulation of mouse keratinocytes by transforming growth factors.

1988 • 242 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.

1994 • 233 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

1994 • 208 citations

Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin

1990 • 196 citations

Stage- and tissue-specific expression of the neu oncogene in rat development.

1987 • 163 citations

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

1992 • 129 citations

Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

1983 • 124 citations

Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

1984 • 113 citations

Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5′-upstream sequences.

1987 • 112 citations

Epidermal Hyperplasia and Wool Follicle Regression in Sheep Infused with Epidermal Growth Factor

1985 • 80 citations

Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat

1983 • 72 citations

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.

1994 • 68 citations

Fibroblast growth factor and epidermal growth factor in hair development

1993 • 64 citations

Differentiation or immune destruction: two pathways for therapy of squamous cell carcinomas with antibodies to the epidermal growth factor receptor.

1994 • 61 citations

Long-Term Consequences of Interleukin-6 Overexpression in Transgenic Mice

1992 • 60 citations

Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

1990 • 56 citations

Inhibition of Wool Growth in Merino Sheep following Administration of Mouse Epidermal Growth Factor and a Derivative

1982 • 48 citations

Epidermal growth factor stimulates tyrosine phosphorylation in the neonatal mouse: association of a M(r) 55,000 substrate with the receptor.

1992 • 40 citations

A Dominant Negative Mutation Suppresses the Function of Normal Epidermal Growth Factor Receptors by Heterodimerization

1991 • 31 citations

The Stimulation of Epidermal Keratinization by a Protein Isolated From the Submaxillary Gland of the Mouse

1989 • 18 citations

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

1990 • 11 citations

Anti-Oncogenic Activity of Signalling-Defective Epidermal Growth Factor Receptor Mutants

1992 • 9 citations