Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors
Data up to Jan 2025
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Abstract
References (66)
A genetic model for colorectal tumorigenesis
1990 • 11,800 citations
The Clonal Evolution of Tumor Cell Populations
1976 • 6,310 citations
Current protocols in molecular biology
1988 • 4,543 citations
CpG-rich islands and the function of DNA methylation
1986 • 3,760 citations
CpG Islands in vertebrate genomes
1987 • 3,315 citations
The mitogen-activated protein kinase signal transduction pathway
1993 • 2,174 citations
Practical Nonparametric Statistics (2nd ed).
1981 • 1,909 citations
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
1994 • 1,542 citations
Practical Nonparametric Statistics.
1981 • 1,388 citations
The 5-methylcytosine content of DNA from human tumors
1983 • 835 citations
Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.
1995 • 713 citations
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.
1991 • 467 citations
Northern blot normalization with a 28S rRNA olinucleotide probe
1989 • 364 citations
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens
1984 • 296 citations
Dependence of transcriptional repression on CpG methylation density.
1994 • 294 citations
DNA Methylation in Folate Deficiency: Use of CpG Methylase
1993 • 286 citations
DNA Methylation and Cancer
2000 • 266 citations
CpNpG methylation in mammalian cells
1995 • 259 citations
Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets
1983 • 258 citations
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
1975 • 257 citations
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
1991 • 248 citations
Two Distinct Raf Domains Mediate Interaction with Ras
1995 • 243 citations
E2F and Cell Proliferation: A World Turned Upside Down
1996 • 234 citations
Differential expression of the ras gene family in mice.
1987 • 222 citations
In vivo response of hepatocytes to growth factors requires an initial priming stimulus
1994 • 222 citations
Alterations in DNA methylation may play a variety of roles in carcinogenesis
1995 • 220 citations
Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency
1993 • 204 citations
Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.
1994 • 200 citations
ALTERED HEPATIC FOCI: Their Role in Murine Hepatocarcinogenesis
1990 • 189 citations
DNA methylation and chromatin structure
1991 • 182 citations
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet
1984 • 165 citations
Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.
1992 • 165 citations
A rapid optimized protocol for downward alkaline Southern blotting of DNA.
1993 • 143 citations
DNA Methylation from Embryo to Adult
1994 • 130 citations
The majority of methylated deoxycytidines in human DNA are not in the CpG dinucleotide
1987 • 128 citations
Predisposition to Neoplastic Transformation Caused by Gene Replacement of H- ras 1
1993 • 117 citations
Morphological classification of mouse liver tumors based on biological characteristics.
1982 • 109 citations
c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino acid-defined diets
1988 • 96 citations
The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat
1992 • 95 citations
Choline Deficiency, Partial Hepatectomy, and Liver Tumors in Rats and Mice
1982 • 94 citations
Transcriptional repression by methylation of CpG
1992 • 93 citations
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
1990 • 91 citations
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration
1996 • 89 citations
The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets
1992 • 86 citations
The Initiation-Promotion-Progression Model of Rat Hepatocarcinogenesis
1993 • 82 citations
Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion
1994 • 81 citations
Quantitative stereological evaluation of four histochemical markers of altered foci in multistage hepatocarcinogenesis in the rat
1987 • 79 citations
Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver.
1990 • 69 citations
Alterations in the methylation status and expression of the raf oncogene in phenobarbital‐induced and spontaneous B6C3F1 mouse liver tumors
1994 • 63 citations
Altered methylation of ras oncogenes in benzidine-induced B6C3F1 mouse liver tumors
1989 • 62 citations
Comparative Tumor-Promoting Activities of Phenobarbital, Amobarbital, Barbital Sodium, and Barbituric Acid on Livers and Other Organs of Male F344/NCr Rats Following Initiation With <italic>N</italic>-Nitrosodiethylamine<xref ref-type="fn" rid="FN2">2</xref>
1985 • 56 citations
Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras.
1994 • 55 citations
Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes
1992 • 53 citations
Hypomethylation of the decorin proteoglycan gene in human colon cancer
1991 • 49 citations
In‐vivo‐modified gonococcal plasmid pJD1
1986 • 36 citations
The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver
1990 • 32 citations
Hypomethylation ofrasoncogenes in chemically induced and spontaneous b6c3f1 mouse liver tumors
1991 • 31 citations
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice
1993 • 31 citations
An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis.
1994 • 30 citations
Repression of transient expression by DNA methylation in transcribed regions of reporter genes introduced into cultured human cells
1995 • 28 citations
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate
1994 • 20 citations
Mechanisms of liver tumor promotion
1995 • 18 citations
Methylation of an α-foetoprotein gene intragenic site modulates gene activity
1992 • 16 citations
Hypomethylation of DNA
1995 • 15 citations
Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice
1995 • 13 citations
Spontaneous mutation at codon 61 of the Ha-ras gene in the nascent liver of B6C3F1, C3H/He and C57BL/6 mice
1994 • 8 citations