ALTERED HEPATIC FOCI: Their Role in Murine Hepatocarcinogenesis

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

New principle for the analysis of chemical carcinogenesis

1976 • 788 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Some Biological Aspects of Skin Carcinogenesis*

2015 • 640 citations

A New, Quantitative, Approach to the Study of the Stages of Chemical Carcinogenesis in the Mouse's Skin

1947 • 532 citations

The stages of initiation and promotion in hepatocarcinogenesis

1980 • 515 citations

Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats—an approach for a new medium-term bioassay system

1988 • 403 citations

Induction of Liver Growth by Xenobiotic Compounds and Other Stimuli

1974 • 352 citations

The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis.

1984 • 336 citations

CONDITIONAL NEOPLASMS AND SUBTHRESHOLD NEOPLASTIC STATES

1941 • 335 citations

Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.

1980 • 243 citations

Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats

1985 • 231 citations

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

1987 • 197 citations

A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat.

1985 • 185 citations

Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis.

1982 • 177 citations

Age- and tissue-related DNA modifications in untreated rats: detection by ³²P-postlabeling assay and possible significance for spontaneous tumor induction and aging

1986 • 152 citations

Models of Hepatocarcinogenesis in the Rat—Contrasts and Comparisons

1986 • 137 citations

Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver

1985 • 135 citations

Development of Preneoplastic and Neoplastic Lesions of the Liver in Male Rats Given 0.025 Percent <italic>N</italic>-2-Fluorenyldiacetamide<xref ref-type="fn" rid="FN2">2</xref>

1965 • 128 citations

Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth.

1984 • 124 citations

Enhancement of Spontaneous Hepatic Tumorigenesis in C3H Mice by Dietary Phenobarbital2

1973 • 122 citations

The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration

1984 • 121 citations

Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study.

1984 • 115 citations

Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.

1981 • 103 citations

Notizen: Histochemische Untersuchungen über die Glucose-6-Phosphatase in der Rattenleber während der Kanzerisierung durch Nitrosamine

1964 • 92 citations

Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis.

1986 • 88 citations

Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase-positive foci in female rats

1986 • 84 citations

Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters

1987 • 83 citations

Growth, regression and cell death in rat liver as related to tissue levels of the hepatomitogen cyproterone acetate

1986 • 77 citations

Phenotypic instability in focal and nodular lesions induced in a short term system in the rat liver

1983 • 76 citations

Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats.

1984 • 72 citations

A new protocol and its rationale for the study of initiation and promotion of carcinogenesis in rat liver

1981 • 71 citations

Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.

1983 • 71 citations

The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital

1985 • 68 citations

Prolactin is a tumor promoter in rat liver

1985 • 66 citations

Histochemical characterization of focal hepatic lesions induced by single diethylnitrosamine treatment in infant mice.

1985 • 62 citations

Quantitative evaluation of hepatic foci of cellular alteration occurring spontaneously in Fischer-344 rats

1985 • 60 citations

Phenobarbital specifically reduces gap junction protein mRNA level in rat liver

1988 • 56 citations

Hepatic Foci of Cellular and Enzymatic Alteration and Nodules in Rats Treated With Clofibrate or Diethylnitrosamine Followed by Phenobarbital: Their Rate of Onset and Their Reversibility

1986 • 53 citations

Background Data and Variations in Tumor Rates of Control Rats and Mice

2015 • 52 citations

Reversibility and irreversibility of liver tumors in mice induced by the alpha isomer of 1,2,3,4,5,6-hexachlorocyclohexane.

1976 • 50 citations

The effect of long-term administration of phenobarbitone in CF-1 mice

1975 • 45 citations

Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver

1984 • 41 citations

Ploidy distribution in experimental liver carcinogenesis in mice

1988 • 37 citations

Influence of dietary fat and selenium in initiation and promotion of aflatoxin B¹-induced preneoplastic foci in rat liver

1987 • 36 citations

Phenobarbital competes with diacylglycerol for protein kinase C

1987 • 35 citations

Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase in rat liver preneoplastic lesions

1988 • 35 citations

The phenotypic stability of altered hepatic foci: effect of the shortterm withdrawal of phenobarbital and of the long-term feeding of purified diets after the withdrawal of phenobarbital

1986 • 34 citations

Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice

1984 • 33 citations

Expression of tumor-associated aldehyde dehydrogenase during rat hepatocarcinogenesis using the resistant hepatocyte model

1984 • 33 citations

Immortal epithelial cells of normal C3H mouse liver in culture: possible precursor populations for spontaneous hepatocellular carcinoma.

1989 • 33 citations

Role of Injury and Hyperplasia in the Induction of Hepatocellular Carcinoma

1961 • 32 citations

Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.

1988 • 30 citations

Dietary effects on initiation and promotion of hepatocarcinogenesis in rat

1988 • 29 citations

Biology of Hepatocellular Neoplasia In the Mouse. II. Sequential Enzyme Histochemical Analysis of BALB/c Mouse Liver During Safrole-Induced Carcinogenesis<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1981 • 28 citations

Age‐Associated Lesions in Barrier‐Reared Male Sprague‐Dawley Rats: A Comparison Between Hap: (SD) and Crl:COBS^[R]CD^[R] (SD)Stocks^1,6

1982 • 27 citations

Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat.

1984 • 27 citations

Spontaneous hepatocellular neoplasms and hepatic hemangiosarcomas in several strains of mice.

1982 • 27 citations

Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.

1979 • 25 citations

Effects of N-nitrosomorpholine and phenobarbital on UDPglucuronyltransferase in putative preneoplastic foci of rat liver

1985 • 25 citations

Dose—time relationship of the development of preneoplastic liver lesions induced in rats with low doses of N-nitrosodiethanolamine

1988 • 25 citations

Spontaneous liver tumors in aged germfree Wistar rats.

1979 • 24 citations

Promotive effect of primary and secondary bile acids on the induction of gamma-glutamyl transpeptidase-positive liver cell foci as a possible endogenous factor for hepatocarcinogenesis in rats.

1984 • 24 citations

Immunohistochemical demonstration of decreased L-pyruvate kinase in enzyme altered rat liver lesions produced by different carcinogens

1987 • 23 citations

Two-Stage Liver Carcinogenesis in the Mouse

1987 • 19 citations

Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride.

1980 • 18 citations

Rapid uptake of dietary cholesterol by hyperplastic liver nodules and primary hepatomas.

1973 • 18 citations

Initiation/promotion bioassay in rat liver: use of gamma glutamyltranspeptidase-positive foci to indicate carcinogenic activity

1982 • 15 citations

Gamma‐glutamyl transpeptidase: A sensitive marker in DDT and toxaphene exposure

1984 • 14 citations

Irreversibility of Liver Tumors in C3H Mice2

1984 • 13 citations

Dose-response relationship for phenobarbitone promotion of liver tumours initiated by single dose dimethylnitrosamine.

1986 • 13 citations

Effect of hexachlorobenzene on male and female rat hepatic gamma-glutamyl transpeptidase levels

1984 • 11 citations

Blockade of α-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters

1989 • 10 citations

Enzyme Pattern and Growth Rate of Liver Preneoplastic Clones during Carcinogenesis by Diethylnitrosamine

1984 • 10 citations

Biology of Hepatocellular Neoplasia In the Mouse. III. Electron Microscopy of Safrole-Induced Hepatocellular Adenomas and Hepatocellular Carcinomas<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1981 • 8 citations

Decreased fibronectin in rat liver altered foci and adenomas induced by N-2-fluorenylacetamide.

1988 • 8 citations

Liver hepatocyte mitotic activity after a single injection of phenobarbital in immature male rats

1976 • 6 citations

Cytochemical studies on tumor cells. VII. Inductivity of glucose 6-phosphate-dehydrogenase in hepatic cells of rats fed azo dye.

1966 • 5 citations

Cell phenotype instability in preneoplastic foci of rat liver

1988 • 3 citations

Detection of gamma glutamyl transpeptidase in the livers of germfree and conventional rats.

1982 • 3 citations

The effect of single versus split doses of diethylnitrosamine on the induction of gamma-glutamyltranspeptidase-foci in the livers of adult and juvenile rats

1986 • 2 citations