Priming of human neutrophil functions by tumor necrosis factor: Enhancement of superoxide anion generation, degranulation, and chemotaxis to chemoattractants C5a and f-Met-Leu-Phe

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor

1985 • 633 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 319 citations

Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor.

1987 • 292 citations

Intracellular control of human neutrophil secretion. I. C5a-induced stimulus-specific desensitization and the effects of cytochalasin B.

1978 • 283 citations

Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor-Alpha

1987 • 219 citations

Effects of Tumour Necrosis Factor Alpha and Interleukin-1 Alpha and Beta on Human Neutrophil Migration, Respiratory Burst and Degranulation

1988 • 178 citations

Recombinant human tumor necrosis factor-alpha. Regulation of N-formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils.

1988 • 162 citations

Intracellular Control of Human Neutrophil Secretion

1978 • 155 citations

Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.

1988 • 149 citations

Regulation of neutrophil migration and superoxide production by recombinant tumor necrosis factors-alpha and -beta: comparison to recombinant interferon-gamma and interleukin-1 alpha

1987 • 147 citations

Effect of tumor necrosis factor and granulocyte/macrophage colony-stimulating factor on neutrophil degranulation.

1989 • 125 citations

Biological effects of recombinant human tumor necrosis factor and its novel muteins on tumor and normal cell lines.

1987 • 124 citations

Tumor necrosis factor is the major monocyte product that increases complement receptor expression on mature human neutrophils

1988 • 123 citations

Tumor necrosis factor as an activator of human granulocytes. Potentiation of the metabolisms triggered by the Ca2+-mobilizing agonists.

1989 • 107 citations

Mechanisms of tumor necrosis factor-alpha alteration of PMN adhesion and migration.

1990 • 93 citations

Activation of Neutrophils by Cachectin/Tumor Necrosis Factor: Priming of N-Formyl-Methionyl-Leucyl-Phenylalanine-Induced Oxidative Responsiveness Via Receptor Mobilization Without Degranulation

1990 • 62 citations

Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors

1978 • 56 citations

Modulation of human neutrophilic granulocyte functions by recombinant human tumor necrosis factor and recombinant human lymphotoxin. Promotion of adherence, inhibition of chemotactic migration and superoxide anion release from adherent cells.

1988 • 51 citations

Modulation of Human Neutrophil and Monocyte Chemotaxis and Superoxide Responses by Recombinant TNF-Alpha and GM-CSF

1988 • 48 citations

Tumor Necrosis Factor—Enhanced Leukotriene B4 Generation and Chemotaxis in Human Neutrophils

1988 • 47 citations

A multifunctional receptor on the neutrophil for synthetic chemotactic oligopeptides.

1979 • 46 citations

Effects of tumor necrosis factor on PMN chemotaxis, chemiluminescence, and elastase activity.

1989 • 36 citations

Recombinant human tumor necrosis factor α lacks chemotactic activity for human peripheral blood neutrophils and monocytes

1988 • 35 citations

Effect of recombinant DNA-produced tumor necrosis factor on various parameters of neutrophil function

1988 • 31 citations

Effects of recombinant tumor necrosis factor (rHuTNFα)on human neutrophils and monocytes: In vitro, ex vivo and in vivo

1989 • 22 citations

Chemotactic activity of lymphotoxin and tumour necrosis factor alpha for human neutrophils.

1989 • 21 citations

A chemotaxis assay using human polymorphonuclear leukocytes stimulated by IL-1

1988 • 11 citations

The priming effects of the products of stimulated mononuclear cells on the response of neutrophils to C5a des arg

1991 • 10 citations

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