The role of oxidative stress in HIV disease

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Lipid peroxidation: its mechanism, measurement, and significance

1993 • 2,324 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS

1989 • 815 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Hypertriglyceridemia in the acquired immunodeficiency syndrome

1989 • 446 citations

Oxygen Radicals in Influenza-Induced Pathogenesis and Treatment with Pyran Polymer-Conjugated SOD

1989 • 420 citations

Glutathione deficiency and human immunodeficiency virus infection

1992 • 409 citations

Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

1990 • 383 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.

1990 • 336 citations

Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine.

1991 • 330 citations

Regulation of the transcription factors NF-κB and AP-1 by redox changes

1994 • 310 citations

Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndrome

1992 • 283 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

The Effect of Cytokines and Pharmacologic Agents on Chronic HIV Infection

1992 • 237 citations

α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells

1992 • 232 citations

Resting energy expenditure is increased in stable, malnourished HIV-infected patients

1991 • 201 citations

Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

1991 • 194 citations

Antioxidant status and lipid peroxidation in patients infected with HIV

1994 • 191 citations

Textbook of AIDS Medicine

1994 • 184 citations

Prospective analysis of patterns of weight change in stage IV human immunodeficiency virus infection

1993 • 171 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

Resting energy expenditure and substrate oxidation in human immunodeficiency virus (HIV)-infected asymptomatic men: HIV affects host metabolism in the early asymptomatic stage

1991 • 165 citations

Intracellular Glutathione Levels in T Cell Subsets Decrease in HIV-Infected Individuals

1992 • 161 citations

N‐Acetylcysteine inhibits apoptosis and decreases viral particles in HIV‐chronically infected U937 cells

1993 • 156 citations

Adverse reactions to co-trimoxazole in HIV infection

1991 • 155 citations

Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS)

1994 • 146 citations

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

1991 • 145 citations

Oxidative stress and apoptosis in HIV infection: a role for plant-derived metabolites with synergistic antioxidant activity

1994 • 140 citations

Resting energy expenditure in human immunodeficiency virus-infected patients: comparison between patients with and without secondary infections

1993 • 135 citations

Increased resting energy expenditure in human immunodeficiency virus-infected men

1990 • 126 citations

Increased Production of Malondialdehyde in Patients with HIV Infection

1988 • 123 citations

Lymphocyte proliferation in glutathione-depleted lymphocytes: direct relationship between glutathione availability and the proliferative response

1989 • 118 citations

Thiol-mediated redox regulation of lymphocyte proliferation. Possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression.

1994 • 114 citations

Leukotriene B₄ transcriptionally activates interleukin‐6 expression involving NK‐xB and NF‐IL6

1992 • 109 citations

Selenium Deficiency in the Acquired Immunodeficiency Syndrome

1986 • 108 citations

The HIV wasting syndrome: a review.

1994 • 105 citations

Cysteine and Glutathione Deficiency in AIDS Patients: A Rationale for the Treatment with IM-Acetyl-Cysteine

1993 • 100 citations

Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase.

1983 • 86 citations

Beta-carotene in HIV infection.

1993 • 83 citations

The generation of oxygen radicals: A positive signal for lymphocyte activation

1988 • 80 citations

Allergic manifestations of human immunodeficiency virus (HIV) infection

1991 • 77 citations

HIV Gene Expression Enhances T Cell Susceptibility to Hydrogen Peroxide-Induced Apoptosis

1993 • 77 citations

N-Acetylcysteine enhances T cell functions and T cell growth in culture

1993 • 73 citations

Selenium in the maintenance and therapy of HIV-infected patients

1994 • 73 citations

Changes in intracellular glutathione levels in stimulated and unstimulated lymphocytes in the presence of 2-mercaptoethanol or cysteine.

1983 • 72 citations

Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells

1991 • 67 citations

Metabolic disorder as early consequence of simian immunodeficiency virus infection in rhesus macaques

1991 • 64 citations

Glutathione metabolism in activated human neutrophils: stimulation of glutathione synthesis and consumption of glutathione by reactive oxygen species

1991 • 60 citations

Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine

1992 • 59 citations

Progressive increases in serum catalase activity in advancing human immunodeficiency virus infection

1992 • 52 citations

Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication.

1993 • 50 citations

Malnutrition in HIV infection and AIDS

1989 • 48 citations

Review Article the B Lymphocyte: A Newly Recognized Source of Reactive Oxygen Species with Immunoregulatory Potential

1990 • 47 citations

Oxy-radicals in molecular biology and pathology

1988 • 39 citations

Nutritional Aspects of AIDS

1990 • 35 citations

Oxidative imbalance in HIV infected patients

1991 • 29 citations

Development of a novel glutathione repleting agent, L-2-oxothiazolidine-4-carboxylic acid (Procysteine®)

1994 • 26 citations

Glutathione and Immunophenotypes of T and B Lymphocytes in HIV‐Infected Individuals^a

1992 • 24 citations

Impaired Immunity in AIDS

1990 • 23 citations

Imbalance between oxidants and antioxidants in the lungs of HIV-seropositive individuals

1994 • 23 citations

Oxygen radical release by neutrophils of HIV-infected patients

1994 • 21 citations

Elevation of glutathione levels by phase II enzyme inducers: lack of inhibition of human immunodeficiency virus type 1 replication in chronically infected monocytoid cells.

1994 • 15 citations

The effect of changes in thiol subcompartments on T-cell colony formation and cell cycle progression: Relevance to AIDS

1992 • 14 citations

B15—Superoxide anion (O2·−) production and enzymatic disbalance in peripheral blood cells isolated from HIV-infected children

1994 • 10 citations

Glutathione deficiency in human HIV infection

1990 • 6 citations