Cerebral Ischemia Produces Laddered DNA Fragments Distinct from Cardiac Ischemia and Archetypal Apoptosis

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

1998 • 899 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

The role of DNA fragmentation in apoptosis

1995 • 608 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

1998 • 554 citations

Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex

1996 • 540 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum

1997 • 339 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective

1997 • 305 citations

The Shape of Cell Death

1997 • 302 citations

Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death

1992 • 270 citations

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

1995 • 258 citations

A new model of temporary focal neocortical ischemia in the rat.

1992 • 225 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits

1996 • 204 citations

Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis.

1996 • 193 citations

Early apoptosis in human myocardial infarcts

1997 • 158 citations

Altered gene expression in brain ischemia.

1997 • 151 citations

Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil

1994 • 150 citations

DNA Fragmentation Follows Delayed Neuronal Death in CA1 Neurons Exposed to Transient Global Ischemia in the Rat

1997 • 146 citations

Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends

1997 • 142 citations

New aspects of the mechanism of DNA fragmentation in apoptosis

1997 • 140 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain

1995 • 130 citations

DNA fragmentation during apoptosis is caused by frequent single-strand cuts

1993 • 129 citations

Apoptosis in the Nervous System: Morphological Features, Methods, Pathology, and Prevention.

1995 • 121 citations

Differences in DNA Fragmentation following Transient Cerebral or Decapitation Ischemia in Rats

1995 • 116 citations

D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum

1996 • 114 citations

DNA Scission After Focal Brain Ischemia

1997 • 107 citations

DNA Fragmentation and HSP70 Protein Induction in Hippocampus and Cortex Occurs in Separate Neurons following Permanent Middle Cerebral Artery Occlusions

1996 • 107 citations

Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat

1996 • 105 citations

DNAase I, DNAase II and staphylococcal nuclease cut at different, yet symmetrically located, sites in the nucleosome core

1978 • 102 citations

Characterization of CPP32‐Like Protease Activity Following Apoptotic Challenge in SH‐SY5Y Neuroblastoma Cells

1997 • 96 citations

Apoptosis in Focal Cerebral Ischemia

1996 • 94 citations

Alterations of Bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centres following focal cerebral ischemia in mice

1998 • 72 citations

Glutamate-Treated Rat Cortical Neuronal Cultures Die in a Way Different from the Classical Apoptosis Induced by Staurosporine

1997 • 64 citations

Detection of Higher-Order 50- and 10-kbp DNA Fragments before Apoptotic Internucleosomal Cleavage after Transient Cerebral Ischemia

1997 • 51 citations

DNA single-strand breaks in postischemic gerbil brain detected by in situ nick translation procedure

1995 • 49 citations

Deoxyribonuclease I produces staggered cuts in the DNA of chromatin

1977 • 46 citations

Role of apoptosis in acute neurodegenerative disorders

1996 • 28 citations

Novobiocin induces the in vivo cleavage of active gene sequences in intact cells.

1986 • 24 citations