Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

1993 • 3,080 citations

Neuropathological Classification of Huntingtonʼs Disease

1985 • 2,517 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Selective Sparing of a Class of Striatal Neurons in Huntington's Disease

1985 • 767 citations

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

1993 • 692 citations

Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's Disease

1985 • 614 citations

Huntington's Disease

1979 • 607 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

1991 • 497 citations

3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin

1991 • 476 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

1995 • 471 citations

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH

1996 • 435 citations

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1993 • 360 citations

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

1993 • 338 citations

Early Loss of Neostriatal Striosome Neurons in Huntingtonʼs Disease

1995 • 319 citations

Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor Malonate

1993 • 303 citations

Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry

1991 • 290 citations

Manganese Injection into the Rat Striatum Produces Excitotoxic Lesions by Impairing Energy Metabolism

1993 • 263 citations

Chronic 3-Nitropropionic Acid Treatment in Baboons Replicates the Cognitive and Motor Deficits of Huntington’s Disease

1996 • 262 citations

THE COEXISTENCE OF BRADYKINESIA AND CHOREA IN HUNTINGTON'S DISEASE AND ITS IMPLICATIONS FOR THEORIES OF BASAL GANGLIA CONTROL OF MOVEMENT

1988 • 261 citations

Patterns of cell loss in Huntington's disease

1987 • 226 citations

Clinical and neuropathologic assessment of severity in Huntington's disease

1988 • 213 citations

Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum

1993 • 206 citations

A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

1990 • 177 citations

The gait abnormality of Huntington's disease

1985 • 159 citations

3‐Nitropropionic Acid Toxicity in the Striatum

1994 • 135 citations

Systemic 3-nitropropionic acid: Behavioral deficits and striatal damage in adult rats

1995 • 126 citations

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

1991 • 117 citations

Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease.

1992 • 115 citations

Mitochondrial Impairment Reduces the Threshold for in Vivo NMDA-Mediated Neuronal Death in the Striatum

1993 • 110 citations

Somatotopic organization in rat striatum: evidence for a combinational map.

1992 • 102 citations

Trinucleotide repeat length and rate of progression of Huntington's disease

1994 • 98 citations

NMDA Receptor Involvement in Toxicity to Dopamine Neurons In Vitro Caused by the Succinate Dehydrogenase Inhibitor 3‐Nitropropionic Acid

1995 • 74 citations

Chronically administered 3-nitropropionic acid induces striatal lesions attributed to dysfunction of the blood-brain barrier

1995 • 73 citations

Correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-intropropionic acid toxicity in rats

1987 • 69 citations

Systemic 3-nitropropionic acid: long-term effects on locomotor behavior

1994 • 62 citations

Brain enzyme and clinical alterations induced in rats and mice by nitroaliphatic toxicants

1985 • 62 citations

New Insights Into the Clinical Features, Pathogenesis and Molecular Genetics of Huntington Disease

1992 • 50 citations

3-nitropropionic acid is an indirect excitotoxin to cultured cerebellar granule neurons

1993 • 44 citations

Systemic or Local Administration of Azide Produces Striatal Lesions by an Energy Impairment-Induced Excitotoxic Mechanism

1994 • 38 citations

Intrastriatal 3-nitropropionic acid

1994 • 38 citations

3-Acetylpyridine Produces Age-Dependent Excitotoxic Lesions in Rat Striatum

1994 • 37 citations

‘Choreic’ movement induced by unilateral kainate lesion of the striatum and l-DOPA administration in monkey

1986 • 36 citations

Increase of ATP levels by glutamate antagonists is unrelated to neuroprotection

1994 • 19 citations