Animal models of dementia

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

1988 • 3,033 citations

Operant Behavior: Areas of Research and Application,

1966 • 2,659 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Assessment in Geriatric Psychopharmacology

1986 • 490 citations

Impaired spatial and sequential learning in rats treated neonatally with <scp>d</scp>‐fenfluramine

2002 • 449 citations

BEHAVIORAL EFFECTS OF SOME PSYCHOPHARMACOLOGICAL AGENTS

1957 • 415 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

A two-trial memory task with automated recording: study in young and aged rats

1992 • 360 citations

Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis

1988 • 289 citations

NGF improves spatial memory in aged rodents as a function of age

1991 • 263 citations

Disruption of central cholinergic systems in the rat by basal forebrain lesions or atropine: Effects on feeding, sensorimotor behaviour, locomotor activity and spatial navigation

1985 • 242 citations

The radial arm maze as a tool in behavioral pharmacology

1987 • 238 citations

Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism

1986 • 224 citations

Modulation of memory processing by neuropeptide Y

1987 • 222 citations

Human nerve growth factor improves spatial memory in aged but not in young rats

1994 • 193 citations

The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

1990 • 190 citations

Delay-dependent short-term memory deficits in aged rats

1988 • 183 citations

Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I

1992 • 183 citations

Habituation of exploratory activity in mice: A screening test for memory enhancing drugs

1982 • 171 citations

Behavioural models in psychopharmacology : theoretical, industrial, and clinical perspectives

1990 • 171 citations

Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task

1992 • 164 citations

Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys

1991 • 163 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 138 citations

Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests

1992 • 132 citations

Memory dysfunctions: an integration of animal and human research from preclinical and clinical perspectives.

1985 • 123 citations

Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM)

1993 • 122 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 122 citations

CGP 36742: The first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys

1993 • 119 citations

Specific modulation of social memory in rats by cholinomimetic and nootropic drugs, by benzodiazepine inverse agonists, but not by psychostimulants

1989 • 115 citations

Effects of lobeline, a nicotinic receptor agonist, on learning and memory

1993 • 109 citations

A new one-trial test for neurobiological studies of memory in rats. II: Effects of piracetam and pramiracetam

1989 • 108 citations

The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice

1993 • 105 citations

5-HT1A receptor agonists improve the performance of normal and scopolamine-impaired rats in an operant delayed matching to position task

1994 • 105 citations

Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II

1992 • 96 citations

Heterogeneity of Alzheimer’s Disease

1992 • 95 citations

Scopolamine degrades spatial working memory but spares spatial reference memory: Dissimilarity of anticholinergic effect and restriction of distal visual cues

1985 • 94 citations

D-Cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task

1992 • 94 citations

Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates

1994 • 92 citations

Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys

1990 • 89 citations

The potent free radical scavenger α-lipoic acid improves memory in aged mice: Putative relationship to NMDA receptor deficits

1993 • 89 citations

The effects of ACE inhibitors captopril and SQ29,852 in rodent tests of cognition

1989 • 86 citations

Acetyl-1-carnitine 2: Effects on learning and memory performance of aged rats in simple and complex mazes

1990 • 84 citations

Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents

1988 • 81 citations

Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B

1990 • 77 citations

Aging and cognition: Facilitation of recent memory in aged nonhuman primates by nimodipine

1990 • 77 citations

Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning.

1994 • 75 citations

Rodent models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the cholinergic hypothesis

1994 • 70 citations

Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM)

1993 • 64 citations

Improvement of cognitive function by MAO-B inhibitor L-deprenyl in aged rats

1991 • 63 citations

Behavioral methods for measuring effects of drugs on learning and memory in animals

1984 • 63 citations

Tetrahydroaminoacridine, 3,4 diaminopyridine and physostigmine: Direct comparison of effects on memory in aged primates

1988 • 62 citations

Old age and cognition: Enhancement of recent memory in aged rats by the calcium channel blocker nimodipine

1992 • 61 citations

Continuous ICV infusion of scopolamine impairs sustained attention of rhesus monkeys

1993 • 56 citations

Toward modeling age-related changes of attentional abilities in rats: Simple and choice reaction time tasks and vigilance

1992 • 55 citations

Effect of AIT-082, a purine analog, on working memory in normal and aged mice

1994 • 54 citations

Proactive interference effects on short-term memory in rats: II. Effects in young and aged rats.

1990 • 52 citations

Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine

1993 • 50 citations

A primate model of Alzheimer's disease

1993 • 48 citations

Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats

1992 • 48 citations

Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task

1994 • 41 citations

Pharmacological studies of a rat spatial delayed nonmatch‐to‐sample task as an animal model of dementia

1991 • 40 citations

Chronic L-deprenyl or L-amphetamine: Equal cognitive enhancement, unequal MAO inhibition

1994 • 39 citations

Dementia : molecules, methods and measures

1991 • 37 citations

Impairment of spontaneous alternation performance by an nmda antagonist: attenuation with non-NMDA treatments

1992 • 34 citations

Age-dependent deficits in radial maze performance in the rat: Effect of chronic treatment with acetyl-l-carnitine

1990 • 34 citations

Measurement of cognitive abilities in Senescent Animals

1987 • 32 citations

Long-term Acetyl-l-carnitine preserves spatial learning in the senescent rat

1989 • 32 citations

Effects of piracetam on indices of cognitive function in a delayed alternation task in young and aged rats

1994 • 31 citations

DAU 6215, a novel 5-HT3 receptor antagonist, improves performance in the aged rat in the Morris water maze task

1993 • 31 citations

Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze

1993 • 29 citations

The interaction of L-deprenyl and scopolamine on spatial learning/memory in rats

1993 • 26 citations

A comparison of the effects of the novel muscarinic receptor agonists L-689,660 and AF102B in tests of reference and working memory

1994 • 25 citations

The effects of serotonergic drugs on short-term spatial memory in rats

1994 • 22 citations

Issues in the development of models for cognitive aging across primate and nonprimate species

1993 • 18 citations

Passive Avoidance Behavior in Mice: Interaction Between Age and Genotype

1986 • 18 citations

Active avoidance learning in old rats chronically treated with levocarnitine acetyl

1992 • 17 citations

The effects of atipamezole, an Alpha-2 antagonist, on the performance of young and aged rats in the delayed nonmatching to position task

1991 • 14 citations

Psychopharmacological Strategies in the Search for Cognition Enhancers

1990 • 14 citations

Effects of idebenone on information processing in aged Long-Evans rats

1993 • 13 citations

The effects of tacrine and zacopride on the performance of adult rats in the working memory task

1993 • 12 citations

The activity of synaptosomal calcium channels is inversely correlated with working memory performance in memory impaired, aged rats

1994 • 12 citations

Age-related behavioral impairments: Benefits of multiple measures of performance

1993 • 9 citations

Facilitating effects of SR 57746A on short‐term memory in an operant delayed alternation task in aged rats

1995 • 9 citations

Effects of oral BMY 21502 on Morris water task performance in 16–18 month old F-344 rats

1992 • 8 citations

Differences in performance of young and old monkeys on a visuospatial memory task.

1993 • 8 citations

Treatment of Age-Related Cognitive Dysfunction: Pharmacological and Clinical Evaluation

1993 • 1 citations