Blood—Brain Barrier Transport and Protein Binding of Flumazenil and Iomazenil in the Rat: Implications for Neuroreceptor Studies

Evaluation of Ultrafiltration for the Free‐Fraction Determination of Single Photon Emission Computed Tomography (SPECT) Radiotracers: β‐CIT, IBF, and Iomazenil

1994 • 188 citations

Effects of Blood Flow on [¹¹C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET Data

1994 • 171 citations

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver.

1985 • 168 citations

Capillary circulation in the brain.

1992 • 167 citations

Flumazenil

1991 • 133 citations

At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.

1989 • 130 citations

Differences in Function and Structure of the Capillary Endothelium in Gray Matter, White Matter and a Circumventricular Organ of Rat Brain

1986 • 96 citations

Differentiation of Radioligand Delivery and Binding in the Brain: Validation of a Two-Compartment Model for [¹¹C]Flumazenil

1991 • 94 citations

Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.

1988 • 85 citations

Transport of Tryptophan into Brain from the Circulating, Albumin‐Bound Pool in Rats and in Rabbits

1990 • 81 citations

Carotid Artery Injection Technique: Bounds for Bolus Mixing by Plasma and by Brain

1985 • 73 citations

Kinetics of protein binding determine rates of uptake of drugs by brain

1986 • 53 citations

Extraction of [^99mTc]—d,l-HM-PAO across the Blood—Brain Barrier

1988 • 52 citations

Hepatic uptake of protein-bound ligands: extended sinusoidal perfusion model

1991 • 44 citations

Testosterone transport in brain: primary role of plasma protein-bound hormone

1985 • 44 citations

Kinetic analysis of cerebrovascular transport based on indicator diffusion technique

1989 • 40 citations

Slightly Altered Permeability—Surface Area Products Imply Some Cerebral Capillary Recruitment during Hypercapnia

1994 • 39 citations

Blood-brain barrier studies in the rat: An indicator dilution technique with tracer sodium as an internal standard for estimation of extracerebral contamination

1976 • 39 citations

Transfer across the human blood-brain barrier: Evidence for capillary recruitment and for a paradox glucose permeability increase in hypocapnia

1982 • 37 citations

Decreased ATP cost of isometric contractions in ATP-depleted rat fast-twitch muscle

1991 • 31 citations

Enhancement of unbound clearance of ICG by plasma proteins, demonstrated in human subjects and interpreted without assumption of facilitating structures

1993 • 24 citations

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

1983 • 18 citations

The Indicator Dilution Method: Assumptions and Applications to Brain Uptake

1983 • 6 citations

The intracarotid ¹³³Xenon injection method for measurement of cerebral blood flow (CBF) in rats: evaluation of the effect of bolus volume

1984 • 5 citations

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