IN VIVO CLASS II TRANSACTIVATOR EXPRESSION IN MICE IS INDUCED BY A NON-INTERFERON-?? MECHANISM IN RESPONSE TO LOCAL INJURY1,2

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

High Survival Rates of Kidney Transplants from Spousal and Living Unrelated Donors

1995 • 1,216 citations

Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril (Iodogen)

1981 • 1,135 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).

1995 • 334 citations

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

1994 • 318 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

1991 • 278 citations

ISCHEMIC ACUTE TUBULAR NECROSIS INDUCES AN EXTENSIVE LOCAL CYTOKINE RESPONSE

1995 • 271 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

INCREASED MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION IN UNILATERAL ISCHEMIC ACUTE TUBULAR NECROSIS IN THE MOUSE

1990 • 260 citations

Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen.

1994 • 247 citations

The “injury response”: A concept linking nonspecific injury, acute rejection, and long-term transplant outcomes

1997 • 224 citations

Activation of class II MHC genes requires both the X ☐ region and the class II transactivator (CIITA)

1995 • 180 citations

IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo.

1997 • 162 citations

Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

1994 • 155 citations

Molecular analysis of G1B and G3A IFNγ mutants reveals that defects in CIITA or RFX result in defective class II MHC and li gene induction

1994 • 145 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.

1996 • 125 citations

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function

1982 • 115 citations

The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes

1995 • 106 citations

Gene expression in nephrotoxic and ischemic acute renal failure.

1994 • 105 citations

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.

1982 • 87 citations

Isolation of a B-cell-specific promoter for the human class II transactivator

1997 • 81 citations

Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes

1995 • 73 citations

Local T cell responses induce widespread MHC expression. Evidence that IFN-gamma induces its own expression in remote sites.

1992 • 72 citations

Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma.

1989 • 71 citations

Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma.

1995 • 65 citations

Regulation of Class II MHC Expression

1996 • 63 citations

Regulation of MHC expression in vivo. Bacterial lipopolysaccharide induces class I and II MHC products in mouse tissues by a T cell-independent, cyclosporine-sensitive mechanism.

1988 • 59 citations

How are class II MHC genes turned on and off?

1995 • 51 citations

Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line.

1990 • 43 citations

Increased class I and class II MHC products and mRNA in kidneys of MRL-lpr/lpr mice during autoimmune nephritis and inhibition by cyclosporine.

1988 • 40 citations

THE INDUCTION OF CLASS I AND II MAJOR HISTOCOMPATIBILITY COMPLEX BY ALLOGENEIC STIMULATION IS DEPENDENT ON THE TRANSCRIPTION FACTOR INTERFERON REGULATORY FACTOR 1 (IRF-1)

1996 • 29 citations

ACUTE RENAL INJURY IN THE INTERFERON-γ GENE KNOCKOUT MOUSE

1995 • 24 citations

Mouse class II transactivator: cDNA sequence and amino acid comparison with the human class II transactivator

1997 • 19 citations

EVIDENCE FOR THE IN VIVO ROLE OF CLASS II TRANSACTIVATOR IN BASAL AND IFN-?? INDUCED CLASS II EXPRESSION IN MOUSE TISSUE1,2

1996 • 16 citations

Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin

1981 • 13 citations

Many forms of renal injury induce a stereotyped response with increased expression of MHC, IFN-y, and adhesion molecules

1997 • 9 citations