Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells ofDrosophila cause abnormal behavioral rhythms

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

Statistical Analysis of Circular Data.

1995 • 2,258 citations

Statistical Analysis of Circular Data

1993 • 1,436 citations

A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila

1999 • 1,122 citations

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

1990 • 1,103 citations

The chi square periodogram: Its utility for analysis of circadian rhythms

1978 • 968 citations

The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila

1998 • 952 citations

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

1995 • 921 citations

CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity

1998 • 861 citations

Statistical Methods for the Analysis of Problems in Animal Orientation and Certain Biological Rhythms.

1966 • 801 citations

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim

1998 • 799 citations

Associative Odor Learning in Drosophila Abolished by Chemical Ablation of Mushroom Bodies

1994 • 790 citations

TheDrosophilamushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells

1997 • 783 citations

Independent Photoreceptive Circadian Clocks Throughout Drosophila

1997 • 628 citations

Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency

1994 • 596 citations

Differential regulation of circadian pacemaker output by separate clock genes in Drosophila

2000 • 531 citations

A light-entrainment mechanism for the Drosophila circadian clock

1996 • 471 citations

Statistics on Spheres.

1984 • 470 citations

Light-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock

1996 • 462 citations

A higher control center of locomotor behavior in the Drosophila brain

1993 • 450 citations

The emergence of order in the Drosophila pupal retina

1989 • 439 citations

Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila

1990 • 404 citations

The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster.

1995 • 401 citations

Regulation of the Drosophila Protein Timeless Suggests a Mechanism for Resetting the Circadian Clock by Light

1996 • 400 citations

Neuroanatomy of cells expressing clock genes inDrosophila: Transgenic manipulation of theperiod andtimeless genes to mark the perikarya of circadian pacemaker neurons and their projections

2000 • 396 citations

Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual system

1988 • 396 citations

Quantitative Analysis of Drosophila period Gene Transcription in Living Animals

1997 • 382 citations

Position Effects on Eukaryotic Gene Expression

1990 • 377 citations

Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

Interlocked Feedback Loops Within the Drosophila Circadian Oscillator

1999 • 361 citations

Neuroblast ablation in Drosophila P[GAL4] lines reveals origins of olfactory interneurons

1997 • 355 citations

Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms

1992 • 326 citations

Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants

1998 • 296 citations

Behavior in Light-Dark Cycles of Drosophila Mutants That Are Arrhythmic, Blind, or Both

1993 • 292 citations

Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells

1997 • 273 citations

A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the drosophila nervous system

1994 • 258 citations

Spatial and Temporal Expression of theperiodandtimelessGenes in the Developing Nervous System ofDrosophila: Newly Identified Pacemaker Candidates and Novel Features of Clock Gene Product Cycling

1997 • 245 citations

Trippings along the trail to the molecular mechanisms of biological clocks

1995 • 242 citations

A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

1987 • 235 citations

The Drosophila CLOCK Protein Undergoes Daily Rhythms in Abundance, Phosphorylation, and Interactions with the PER–TIM Complex

1998 • 231 citations

Probing the function of Drosophila melanogaster accessory glands by directed cell ablation.

1993 • 226 citations

Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.

1994 • 223 citations

Circadian Regulation of a Drosophila Homolog of the Mammalian Clock Gene: PER and TIM Function as Positive Regulators

1998 • 217 citations

Mushroom Bodies Suppress Locomotor Activity in Drosophila melanogaster

1998 • 211 citations

Organization of the Circadian System in Insects

1998 • 206 citations

Disruption of a Behavioral Sequence by Targeted Death of Peptidergic Neurons in Drosophila

1997 • 203 citations

Central complex substructures are required for the maintenance of locomotor activity in Drosophila melanogaster

1999 • 189 citations

THE MOLECULAR CONTROL OF CIRCADIAN BEHAVIORAL RHYTHMS AND THEIR ENTRAINMENT IN DROSOPHILA

1998 • 186 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

Transplantation of a circadian pacemaker in Drosophila

1979 • 172 citations

Behavior of period-altered circadian rhythm mutants ofDrosophila in light: Dark cycles (Diptera: Drosophilidae)

1992 • 169 citations

Germ-Line Transformation Involving DNA from theperiodLocus inDrosophila melanogaster: Overlapping Genomic Fragments that Restore Circadian and Ultradian Rhythmicity toper⁰andper⁻Mutants

1986 • 168 citations

Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila

1997 • 160 citations

Isolation and Chronobiological Analysis of a Neuropeptide Pigment-Dispersing Factor Gene in Drosophila melanogaster

1998 • 158 citations

Spatial and temporal expression of the period gene in Drosophila melanogaster.

1988 • 157 citations

Smell and Taste Perception inDrosophila melanogasterLarva: Toxin Expression Studies in Chemosensory Neurons

1999 • 145 citations

The disconnected Visual System Mutations in Drosophila melanogaster Drastically Disrupt Circadian Rhythms

1989 • 138 citations

Targeted ablation of glia disrupts axon tract formation in the Drosophila CNS

1995 • 134 citations

decapentaplegicOverexpression AffectsDrosophilaWing and Leg Imaginal Disc Development andwinglessExpression

1996 • 131 citations

Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host

2000 • 127 citations

DrosophilaPhotoreceptors Contain an Autonomous Circadian Oscillator That Can Function withoutperiodmRNA Cycling

1998 • 118 citations

Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling.

1997 • 114 citations

Neuronal determination during embryonic development of the grasshopper nervous system

1985 • 113 citations

Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila

1982 • 112 citations

Targeted Expression of TruncatedGluedDisrupts Giant Fiber Synapse Formation inDrosophila

1999 • 104 citations

Temporal and Spatial Expression Patterns of Transgenes Containing Increasing Amounts of theDrosophilaClock Geneperiodand alacZReporter: Mapping Elements of the PER Protein Involved in Circadian Cycling

1997 • 103 citations

In situ localization of the per clock protein during development of Drosophila melanogaster.

1988 • 101 citations

Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.

1992 • 89 citations

Postsynaptic expression of tetanus toxin light chain blocks synaptogenesis in Drosophila

1999 • 87 citations

The molecular machinery for fast and slow neurosecretion

1994 • 82 citations

Molecular and Behavioral Analysis of Four period Mutants in Drosophila melanogaster Encompassing Extreme Short, Novel Long, and Unorthodox Arrhythmic Types

1998 • 81 citations

Eukaryotic circadian systems: cycles in common

1999 • 81 citations

Circadian rhythms: molecular basis of the clock

1998 • 77 citations

A New Mutation at thePeriodLocus ofDrosophila MelanogasterWith Some Novel Effects on Circadian Rhythms

1989 • 76 citations

Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations

1998 • 68 citations

Drosophilarhythms: from brain to behavior

1996 • 53 citations

tim^rit Lengthens Circadian Period in a Temperature-Dependent Manner through Suppression of PERIOD Protein Cycling and Nuclear Localization

1999 • 51 citations

Two Alternatively Spliced Transcripts from the Drosophila period Gene Rescue Rhythms Having Different Molecular and Behavioral Characteristics

1998 • 50 citations

Involvement of the period Gene in Developmental Time-Memory: Effect of the per^Short Mutation on Phase Shifts Induced by Light Pulses Delivered to Drosophila Larvae

2000 • 49 citations

Mutant molecular motors disrupt neural circuits inDrosophila

1997 • 48 citations

Neuropil Pattern Formation and Regulation of Cell Adhesion Molecules inDrosophilaOptic Lobe Development Depend on Synaptobrevin

1999 • 44 citations

Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals

1994 • 41 citations

Drosophila P[Gal4] lines reveal that motor neurons involved in feeding persist through metamorphosis.

1998 • 32 citations

PASting together the mammalian clock

1998 • 29 citations

Drosophila P[Gal4] lines reveal that motor neurons involved in feeding persist through metamorphosis

1998 • 28 citations

Activating inhibitors and inhibiting activators: a day in the life of a fly

1998 • 28 citations

The multiple roles of per in the Drosophila circadian clock

1995 • 26 citations

The secretion of classical and peptide cotransmitters from a single presynaptic neuron involves a synaptobrevin-like molecule.

1997 • 26 citations

Second generation enhancer traps

1993 • 24 citations

The Secretion of Classical and Peptide Cotransmitters from a Single Presynaptic Neuron Involves a Synaptobrevin-Like Molecule

1997 • 23 citations

Pattern regulation during the development of the ventral abdomen in the flesh fly Sarcophaga agryostoma

1989 • 6 citations