Activating inhibitors and inhibiting activators: a day in the life of a fly

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

1998 • 820 citations

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim

1998 • 799 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless

1998 • 718 citations

Expression of a Gene Cluster kaiABC as a Circadian Feedback Process in Cyanobacteria

1998 • 711 citations

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

1998 • 678 citations

CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless

1998 • 631 citations

Independent Photoreceptive Circadian Clocks Throughout Drosophila

1997 • 628 citations

A light-entrainment mechanism for the Drosophila circadian clock

1996 • 471 citations

Light-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock

1996 • 462 citations

Temporal phosphorylation of the Drosophila period protein.

1994 • 410 citations

Regulation of the Drosophila Protein Timeless Suggests a Mechanism for Resetting the Circadian Clock by Light

1996 • 400 citations

Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and Timeless

1996 • 322 citations

Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock

1995 • 275 citations

Resetting the Drosophila Clock by Photic Regulation of PER and a PER-TIM Complex

1996 • 272 citations

GENETIC AND MOLECULAR ANALYSIS OF CIRCADIAN RHYTHMS

1996 • 267 citations

A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the drosophila nervous system

1994 • 258 citations

Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling

1997 • 257 citations

Spatial and Temporal Expression of theperiodandtimelessGenes in the Developing Nervous System ofDrosophila: Newly Identified Pacemaker Candidates and Novel Features of Clock Gene Product Cycling

1997 • 245 citations

Trippings along the trail to the molecular mechanisms of biological clocks

1995 • 242 citations

A Circadian Enhancer Mediates PER-Dependent mRNA Cycling in Drosophila melanogaster

1997 • 237 citations

Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.

1994 • 223 citations

Circadian Systems: General Perspective

1981 • 213 citations

Circadian oscillations in period gene mRNA levels are transcriptionally regulated.

1992 • 212 citations

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.

1995 • 205 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila

1997 • 160 citations

Rhythms ofDrosophila periodgene expression in culture

1997 • 130 citations

Ontogeny of a biological clock in Drosophila melanogaster.

1992 • 128 citations

Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators.

1994 • 127 citations

DrosophilaPhotoreceptors Contain an Autonomous Circadian Oscillator That Can Function withoutperiodmRNA Cycling

1998 • 118 citations

Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling.

1997 • 114 citations

Temporal and Spatial Expression Patterns of Transgenes Containing Increasing Amounts of theDrosophilaClock Geneperiodand alacZReporter: Mapping Elements of the PER Protein Involved in Circadian Cycling

1997 • 103 citations

Rhythmic Expression of a PER-Reporter in the Malpighian Tubules of Decapitated Drosophila: Evidence for a Brain-Independent Circadian Clock

1997 • 102 citations

In situ localization of the per clock protein during development of Drosophila melanogaster.

1988 • 101 citations

Circadian-clock regulation of gene expression

1993 • 90 citations

Molecular clocks: mastering time by gene regulation

1998 • 83 citations

Persistent Diurnal Rhythmicity in Drosophila Emergence1

1955 • 79 citations

Circadian Cycling of a PERIOD-β-galactosidase Fusion Protein in Drosophila: Evidence for Cyclical Degradation

1997 • 68 citations

Embryonic expression of the period clock gene in the central nervous system of Drosophila melanogaster.

1986 • 56 citations

Circadian rhythms: From behaviour to molecules

1997 • 38 citations

New cogwheels in the clockworks

1998 • 30 citations

Molecular Components of a Model Circadian Clock

1998 • 5 citations

Molecular Components of a Model Circadian Clock: Lessons from Drosophila

2019 • 3 citations