Stressors, Stress, and Neuroendocrine Integration of the Adaptive Response: The 1997 Hans Selye Memorial Lecture

The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis

1992 • 3,026 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

Hippocampal atrophy in recurrent major depression.

1996 • 1,884 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Clinical and Biochemical Manifestations of Depression

1988 • 1,052 citations

Clinical Characteristics of Women With a History of Childhood Abuse

1997 • 915 citations

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

1996 • 889 citations

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

1986 • 773 citations

Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates

1993 • 762 citations

Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome

1991 • 736 citations

Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients

1994 • 657 citations

Human leptin levels are pulsatile and inversely related to pituitary–ardenal function

1997 • 632 citations

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.

1993 • 555 citations

Clinical and Biochemical Manifestations of Depression

1988 • 528 citations

Acute Hypothalamic–Pituitary–Adrenal Responses to the Stress of Treadmill Exercise

1987 • 520 citations

Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia

1994 • 506 citations

Bone Mineral Density in Women with Depression

1996 • 458 citations

Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.

1993 • 424 citations

Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications.

1996 • 420 citations

Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis

1992 • 341 citations

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.

1996 • 295 citations

Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion.

1994 • 251 citations

Circadian Relationships between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis

1997 • 242 citations

Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states

1993 • 242 citations

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans

1993 • 241 citations

Syndromes of Glucocorticoid Resistance

1993 • 237 citations

Altered pain perception and psychosocial features among women with gastrointestinal disorders and history of abuse: A preliminary model

1994 • 232 citations

Hypothalamic corticotropin-releasing hormone suppression during the postpartum period: implications for the increase in psychiatric manifestations at this time.

1996 • 226 citations

Dose Effects of Recombinant Human lnterleukin-6 on Pituitary Hormone Secretion and Energy Expenditure

1997 • 225 citations

Stress-induced intracranial mast cell degranulation: a corticotropin- releasing hormone-mediated effect

1995 • 225 citations

The Longitudinal Course of Psychopathology in Cushing’s Syndrome after Correction of Hypercortisolism

1997 • 225 citations

Clinical characteristics of women with a history of childhood abuse: unhealed wounds

1997 • 185 citations

CSF corticotropin-releasing hormone in depressed patients and normal control subjects

1987 • 183 citations

Multiple sclerosis is associated with alterations in hypothalamic-pituitary-adrenal axis function.

1994 • 175 citations

The maternal hypothalamic–pituitary–adrenal axis in the third trimester of human pregnancy

1996 • 161 citations

Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls

1994 • 160 citations

Hormonal Regulation of Human Corticotropin-Releasing Hormone Gene Expression: Implications for the Stress Response and Immune/Inflammatory Reaction

1994 • 158 citations

Psychopathology in patients with endogenous Cushing's syndrome: ‘atypical’ or melancholic features

1995 • 147 citations

Cerebrospinal Fluid Immunoreactive Cortieotropin-Releasing Hormone and Adrenocorticotropin Secretion in Cushing's Disease and Major Depression: Potential Clinical Implications

1991 • 146 citations

Carbohydrate and Lipid Metabolism in Endogenous Hypercortisolism: Shared Features with Metabolic Syndrome X and NIDDM.

1996 • 144 citations

Abnormal Pituitary-Adrenal Responses to Corticotropin-Releasing Hormone in Patients with Seasonal Affective Disorder: Clinical and Pathophysiological Implications

1991 • 135 citations

Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis.

1993 • 126 citations

The Longitudinal Course of Psychopathology in Cushing's Syndrome after Correction of Hypercortisolism

1997 • 107 citations

Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids

1996 • 90 citations

Hypothalamic corticotropin-releasing hormone suppression during the postpartum period: implications for the increase in psychiatric manifestations at this time

1996 • 89 citations

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

1996 • 86 citations

The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: Suggestion of mild chronic hypercortisolism

1993 • 85 citations

Arachidonic Acid Metabolites Modulate Rat Hypothalamic Corticotropin-Releasing Hormone Secretion in vitro

1989 • 80 citations

Presence of immunoreactive corticotropin-releasing hormone in normal and polycystic human ovaries.

1994 • 75 citations

Impairment of Adrenocortical Function Associated with Increased Plasma Tumor Necrosis Factor-Alpha and Interleukin-6 Concentrations in African Trypanosomiasis

1994 • 70 citations

Circadian Relationships between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis

1997 • 61 citations

Interaction of Epidermal Growth Factor With the Hypothalamic-Pituitary-Adrenal Axis: Potential Physiologic Relevance*

1988 • 59 citations

Multiple sclerosis is associated with alterations in hypothalamic- pituitary-adrenal axis function

1994 • 59 citations

Rat hypothalamic corticotropin-releasing hormone secretion is stimulated by interleukin-1 in an eicosanoid-dependent manner

1990 • 57 citations

Differences in Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol before and after Weight Loss

1997 • 52 citations

The role of corticotropin-releasing hormone in neuroendocrine-immune interactions

1997 • 50 citations

Decreased central and peripheral catecholaminergic activation in obese Zucker rats.

1995 • 49 citations

Presence of immunoreactive corticotropin-releasing hormone in normal and polycystic human ovaries

1994 • 27 citations

Introduction: The Concept of Stress and Its Historical Development

1988 • 22 citations

Hormonal regulation of human corticotropin-releasing hormone gene expression: implications for the stress response and immune/inflammatory reaction

1994 • 19 citations

Differences in Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol before and after Weight Loss

1997 • 13 citations

Decreased central and peripheral catecholaminergic activation in obese Zucker rats

1995 • 12 citations

Rat hypothalamic corticotropin-releasing hormone secretion is stimulated by interleukin-1 in an eicosanoid-dependent manner

1990 • 11 citations

The Future of Pediatric and Adolescent Endocrinology

1997 • 7 citations