Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1997 • 1,147 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

The Cerebellum and the Adaptive Coordination of Movement

1992 • 972 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Caspases and caspase inhibitors

1997 • 573 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Delayed (“Secondary”) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy

1994 • 548 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1995 • 356 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Specific Inhibition of Apoptosis after Cerebral Hypoxia-Ischemia by Moderate Post-Insult Hypothermia

1995 • 283 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

1995 • 258 citations

The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration

1991 • 252 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

Outcome after ischemia in the developing sheep brain: An electroencephalographic and histological study

1992 • 217 citations

Oxford Textbook of Pathology

1994 • 210 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

The Effect of Prolonged Modification of Cerebral Temperature on Outcome after Hypoxic-Ischemic Brain Injury in the Infant Rat

1996 • 179 citations

Magnetic resonance and near infrared spectroscopy for investigation of perinatal hypoxic-ischaemic brain injury.

1989 • 176 citations

Different Cleavage Pattern for Poly(ADP-Ribose) Polymerase during Necrosis and Apoptosis in HL-60 Cells

1996 • 166 citations

Neuroprotective Effects of Inhibiting Poly(ADP-Ribose) Synthetase on Focal Cerebral Ischemia in Rats

1997 • 158 citations

Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil

1994 • 150 citations

Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy

1997 • 144 citations

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

1997 • 141 citations

Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?

1993 • 141 citations

Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult

1994 • 130 citations

Apoptosis in the Brains of Infants Suffering Intrauterine Cerebral Injury

1997 • 128 citations

Diaschisis

1993 • 125 citations

Crossed Cerebellar Diaschisis and Brain Recovery After Stroke

1995 • 125 citations

Poly(ADP‐ribose) polymerase: Early involvement in glutamate‐induced neurotoxicity in cultured cerebellar granule cells

1994 • 122 citations

Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis

1996 • 121 citations

Evidence for hypoxia‐induced, programmed cell death of cultured neurons

1994 • 120 citations

Early Endonuclease Activation following Reversible Focal Ischemia in the Rat Brain

1995 • 97 citations

Apoptosis in neural development and disease

1997 • 90 citations

Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

1997 • 82 citations

Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats

1997 • 68 citations

Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons

1997 • 65 citations

EDITORIAL. REGULATION OF APOPTOSIS BY Bcl-2 AND ITS RELATED PROTEINS: IMMUNOCHEMICAL CHALLENGES AND THERAPEUTIC IMPLICATIONS

1996 • 44 citations

Bcl‐2 antagonizes apoptotic cell death induced by two new ceramide analogues

1997 • 36 citations

Secondary changes in cerebellar perfusion (diaschisis) in hemiplegia during childhood: SPECT study of 55 children

1993 • 22 citations

Old cells never die, they just apoptose

1994 • 19 citations