Endothelial Nuclear Factor-κB Translocation and Vascular Cell Adhesion Molecule-1 Induction by Complement

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

1996 • 473 citations

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

1993 • 452 citations

The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion

1996 • 382 citations

Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.

1993 • 352 citations

The Cytolytically Inactive Terminal Complement Complex Activates Endothelial Cells to Express Adhesion Molecules and Tissue Factor Procoagulant Activity

1997 • 318 citations

Fluid Flow Inhibits Endothelial Adhesiveness

1996 • 300 citations

IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.

1990 • 286 citations

Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation

1994 • 283 citations

Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease

1994 • 247 citations

Nitric Oxide Protects Against Leukocyte-Endothelium Interactions in the Early Stages of Hypercholesterolemia

1995 • 243 citations

Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-kappa B activation.

1997 • 227 citations

Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin and ICAM-1.

1995 • 214 citations

On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety.

1995 • 195 citations

Immunohistochemical Demonstration of Enzymatically Modified Human LDL and Its Colocalization With the Terminal Complement Complex in the Early Atherosclerotic Lesion

1998 • 186 citations

The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells.

1996 • 161 citations

Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury

1994 • 154 citations

Complement C6 Deficiency Protects Against Diet-Induced Atherosclerosis in Rabbits

1998 • 135 citations

Leukocyte-Endothelium Interaction During the Early Stages of Hypercholesterolemia in the Rabbit

1998 • 132 citations

The complement system in myocardial ischaemia/reperfusion injury

1994 • 126 citations

Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis

1987 • 116 citations

Polymorphonuclear Leukocyte-Platelet Interaction: Role of P-Selectin in Thromboxane B2 and Leukotriene C4 Cooperative Synthesis

1994 • 109 citations

Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes

1997 • 103 citations

Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells.

1993 • 101 citations

Complement-Induced Release of Monocyte Chemotactic Protein-1 From Human Smooth Muscle Cells

1996 • 98 citations

Reoxygenation of Hypoxic Human Umbilical Vein Endothelial Cells Activates the Classic Complement Pathway

1997 • 92 citations

Nitric Oxide Induces Apoptotic Death of Cardiomyocytes via a Cyclic-GMP-Dependent Pathway

1999 • 91 citations

Early accumulation of the terminal complement-complex in the ischaemic myocardium after reperfusion

1994 • 91 citations

Complement-Mediated Loss of Endothelium-Dependent Relaxation of Porcine Coronary Arteries

1995 • 74 citations

Nitric Oxide Attenuates Reoxygenation-induced ICAM-1 Expression in Coronary Microvascular Endothelium: Role of NFκB

1997 • 69 citations

Platelet Activation and Interactions with the Microvasculature

1996 • 69 citations

Quantitative measurement of SC5b-9 and C5b-9(m) in infarcted areas of human myocardium

1990 • 65 citations

Immunohistochemical Colocalization of the Terminal Complex of Human Complement and Smooth Muscle Cell α-Actin in Early Atherosclerotic Lesions

1997 • 64 citations

N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo.

1997 • 62 citations

Complement activation following reoxygenation of hypoxic human endothelial cells: Role of intracellular reactive oxygen species, NF-κB and new protein synthesis

1998 • 61 citations

Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction

1998 • 59 citations

Neutrophil adhesion to human endothelial cells is induced by the membrane attack complex: the roles of P-selectin and platelet activating factor.

1998 • 59 citations

In vitro and in vivo inhibition of complement activity by a single-chain Fv fragment recognizing human C5

1995 • 53 citations

Influence of the terminal complement-complex on reperfusion injury, no-reflow and arrhythmias: a comparison between C6-competent and C6-deficient rabbits

1996 • 49 citations

Altered beta-adrenergic and cholinergic pulmonary vascular responses after total cardiopulmonary bypass

1995 • 33 citations

PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats

1996 • 30 citations

Complement-induced endothelial dysfunction in rabbits: mechanisms, recovery, and gender differences

1996 • 26 citations

Inhibition of nitric oxide formation and superoxide generation during reduction of LY83583 by neuronal nitric oxide synthase

1998 • 23 citations

The inhibition of cytochrome c oxidase by nitric oxide using S-nitrosoglutathione

1997 • 13 citations

The relationship between macrophages and C5b-9 complement complexes in human atherosclerosis

1988 • 12 citations