The interaction of thymidylate synthase expression with p53-regulated signaling pathways in tumor cells

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

2000 • 3,261 citations

Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil–Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer

2000 • 1,394 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

1995 • 668 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Metabolism and mechanism of action of 5-fluorouracil

1990 • 431 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

1991 • 360 citations

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

1998 • 338 citations

Cancer chemotherapy and biological response modifiers annual

1987 • 273 citations

Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.

1992 • 226 citations

p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.

1998 • 213 citations

P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma.

2001 • 198 citations

Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

1992 • 195 citations

Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil

1995 • 172 citations

Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma

1993 • 163 citations

<i>p53</i> Gene Mutation, Microsatellite Instability and Adjuvant Chemotherapy: Impact on Survival of 388 Patients with Dukes’ C Colon Carcinoma

2000 • 146 citations

Antifolate Drugs in Cancer Therapy

1999 • 124 citations

Regulation of p53 expression by thymidylate synthase

1999 • 119 citations

The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.

2002 • 100 citations

Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex

1999 • 94 citations

Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells

1995 • 70 citations

Thymidylate Synthase Binds to c-myc RNA in Human Colon Cancer Cells and In Vitro

1995 • 69 citations

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

1995 • 67 citations

Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.

2001 • 58 citations

Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.

1994 • 42 citations

Preclinical Pharmacology Studies and the Clinical Development of a Novel Multitargeted Antifolate, MTA (LY231514)

1999 • 40 citations

Downregulation of p21/WAF1 Expression by Thymidylate Synthase

2001 • 16 citations