Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death

1999 • 579 citations

Cancer Chemotherapy: Principles and Practice

1990 • 568 citations

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

1997 • 560 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

The Mechanism of Action of Antitumor Platinum Compounds

1979 • 408 citations

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.

1991 • 375 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

1991 • 360 citations

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1988 • 314 citations

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

1989 • 246 citations

Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.

1992 • 226 citations

Identification of an RNA binding site for human thymidylate synthase.

1993 • 178 citations

Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma

1993 • 163 citations

A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle

1997 • 153 citations

ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group.

1996 • 128 citations

Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition.

1995 • 124 citations

Regulation of p53 expression by thymidylate synthase

1999 • 119 citations

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

1995 • 105 citations

Structural and functional analysis of the human thymidylate synthase gene

1990 • 97 citations

Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex

1999 • 94 citations

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.

1997 • 93 citations

The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme

1993 • 87 citations

Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil.

1984 • 80 citations

Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells

1995 • 70 citations

Thymidylate Synthase Binds to c-myc RNA in Human Colon Cancer Cells and In Vitro

1995 • 69 citations

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

1995 • 67 citations

Resistance to Tomudex (ZD1694): Multifactorial in human breast and colon carcinoma cell lines

1996 • 52 citations

Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells.

1992 • 49 citations