In vitroerythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Molecular Cell Biology

1986 • 5,808 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

The in vitro micronucleus technique

2000 • 2,456 citations

The micronucleus test

1975 • 2,322 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

Measurement of micronuclei in lymphocytes

1985 • 1,807 citations

Molecular Cell Biology

2002 • 1,145 citations

Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetic Toxicity Assays

1987 • 818 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

2001 • 691 citations

Micronuclei as an index of cytogenetic damage: Past, present, and future

1991 • 553 citations

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system

2003 • 390 citations

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.

1977 • 297 citations

Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B)

1997 • 278 citations

Carcinogenicity of mutagens: predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity.

1987 • 275 citations

Chemical mutagen testing on in vivo somatic mammalian cells

1973 • 263 citations

DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal

1990 • 213 citations

Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6^ collaborative study by CSGMT/JEMS MMS. Collaborative study of the Micronucleus Group Test

1997 • 179 citations

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

1999 • 146 citations

The automated bone marrow micronucleus test

1989 • 121 citations

Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer

1996 • 117 citations

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.

1985 • 113 citations

Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells

1978 • 113 citations

Contribution of O⁶‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines

1993 • 112 citations

3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance.

2002 • 77 citations

In vivo hprt mutant frequencies in T-cells of normal human newborns

1990 • 77 citations

Three consistent patterns of response to substituted acridines in a variety of bacterial tester strains used for mutagenicity testing

1985 • 75 citations

Chromosome aberrations induced in vitro: Mechanisms, delayed expression, and intriguing questions

1994 • 60 citations

Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

2004 • 56 citations

In VivoSelection of Human Hematopoietic Cells in a Xenograft Model Using Combined Pharmacologic and Genetic Manipulations

2003 • 47 citations

Stringent Regulation of DNA Repair During Human Hematopoietic Differentiation: A Gene Expression and Functional Analysis

2005 • 40 citations

Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.

2003 • 37 citations

Automation of mouse micronucleus genotoxicity assay by laser scanning cytometry

2001 • 33 citations

The P140K mutant of humanO6-methylguanine-DNA-methyltransferase (MGMT) confers resistancein vitro andin vivo to temozolomide in combination with the novel MGMT inactivatorO6-(4-bromothenyl)guanine

2005 • 32 citations

Prior bleeding enhances the sensitivity of the in vivo micronucleus test

1991 • 31 citations

Gene transfer to suppress bone marrow alkylation sensitivity

2000 • 24 citations

A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase

2006 • 23 citations

Effect of Cations on the Formation of DNA Alkylation Products in DNA Reacted with 1-(2-Chloroethyl)-1-nitrosourea

1999 • 21 citations

Flow cytometric analysis of micronucleated reticulocytes in mouse bone marrow

1997 • 21 citations

Genotoxicity of genetic recombinant human erythropoietin in a novel test system

1993 • 21 citations

In Vivo Effects of Myeloablative Alkylator Therapy on Survival and Differentiation of MGMTP140K-Transduced Human G-CSF-Mobilized Peripheral Blood Cells

2006 • 17 citations

Hematopoiesis

2001 • 13 citations

Increased Mutagenicity of Chloroethylnitrosoureas in the Presence of a Rat Liver S9 Microsome Mixture<xref ref-type="fn" rid="fn2">2</xref>

1983 • 2 citations