Tissue-Specific and Ectopic Expression of Genes Introduced into Transgenic Mice by Retroviruses

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Nucleotide sequence of Moloney murine leukaemia virus

1981 • 1,079 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

1986 • 533 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus.

1976 • 491 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene

1983 • 422 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences

1984 • 312 citations

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.

1982 • 299 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells

1986 • 236 citations

Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice

1985 • 235 citations

Retroviruses as probes for mammalian development: Allocation of cells to the somatic and germ cell lineages

1986 • 213 citations

Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal.

1975 • 198 citations

A 3′ enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult β-globin gene

1986 • 192 citations

Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene

1984 • 187 citations

Correcting an immune-response deficiency by creating Eα gene transgenic mice

1985 • 171 citations

Developmental regulation of alpha-fetoprotein genes in transgenic mice.

1985 • 154 citations

Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector.

1987 • 153 citations

Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.

1985 • 145 citations

Efficient insertion of genes into the mouse germ line via retroviral vectors.

1985 • 126 citations

Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice

1985 • 126 citations

Methylation, expression and chromosomal position of genes in mammals

1984 • 100 citations

Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection.

1985 • 98 citations

Correction of Murine β-Thalassemia by Gene Transfer into the Germ Line

1986 • 93 citations

Expression of foreign genes from retroviral vectors in mouse teratocarcinoma chimaeras.

1985 • 62 citations

Chromosomal Position and Specific Demethylation in Enhancer Sequences of Germ Line-Transmitted Retroviral Genomes During Mouse Development

1985 • 60 citations

Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.

1985 • 44 citations

Introduction of genes into preimplantation mouse embryos by use of a defective recombinant retrovirus.

1986 • 37 citations

Expression of Human β-Globin Genes in Transgenic Mice: Effects of a Flanking Metallothionein-Human Growth Hormone Fusion Gene

1985 • 36 citations

Gene Transfer into Murine Stem Cells and Mice Using Retroviral Vectors

1985 • 35 citations