Expression of Human β-Globin Genes in Transgenic Mice: Effects of a Flanking Metallothionein-Human Growth Hormone Fusion Gene

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I

1980 • 486 citations

Introduction of a rabbit β-globin gene into the mouse germ line

1981 • 458 citations

A practical approach for quantitating specific mRNAs by solution hybridization

1983 • 427 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring.

1981 • 320 citations

Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences

1984 • 312 citations

The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.

1981 • 285 citations

Histone-h1-dependent chromatin superstructures and the suppression of gene activity

1984 • 251 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

DNA sequences required for regulated expression of β-globin genes in murine erythroleukemia cells

1984 • 241 citations

Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice

1985 • 235 citations

Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene

1984 • 187 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

Isolation and Characterization of Modified Globin Messenger Ribonucleic Acid from Erythropoietic Mouse Spleen

1974 • 42 citations

DNA sequences required for regulated expression of β-globin genes in murine erythroleukaemia cells

1984 • 31 citations