Inhibition of platelet activation by tyrosine kinase inhibitors

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Oncogenes and signal transduction

1991 • 2,816 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.

1985 • 270 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Tyrphostins—Potential antiproliferative agents and novel molecular tools

1990 • 177 citations

Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.

1988 • 166 citations

Myosin phosphorylation in intact platelets.

1981 • 148 citations

Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets

1989 • 148 citations

Ca^{2 +}‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

1987 • 130 citations

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.

1990 • 126 citations

Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins.

1992 • 99 citations

In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C

1989 • 95 citations

Calcium-dependent turnover of brain polyphosphoinositides in vitro after prelabelling in vivo

1981 • 92 citations

Functional implications of tyrosine protein phosphorylation in platelets. Simultaneous studies with different agonists and inhibitors

1992 • 80 citations

The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.

1991 • 75 citations

Phosphorylation of bovine platelet myosin by protein kinase C

1990 • 71 citations

Expression of p60fyn in human platelets.

1990 • 70 citations

Molecular analysis of pleckstrin: The major protein kinase c substrate of platelets

1989 • 68 citations

Erbstatin blocks platelet activating factor‐induced protein‐tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets

1990 • 68 citations

High pp60c-src level in human platelet dense bodies

1989 • 64 citations

Inositol lipid metabolism in the responses of stimulted platelets

1982 • 58 citations

Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins

1992 • 44 citations

Collagen-induced platelet activation mainly involves the protein kinase C pathway

1990 • 33 citations

Signal transduction in normal and pathological thrombin-stimulated human platelets

1987 • 22 citations

Tyrosine kinase blockers: new platelet activation inhibitors.

1990 • 9 citations