Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

1996 • 1,461 citations

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

2003 • 1,079 citations

Imaging Synaptic Neurotransmission within VivoBinding Competition Techniques: A Critical Review

2000 • 938 citations

Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate

1998 • 878 citations

Detection of dopamine dynamics in the brain

1988 • 762 citations

Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine

1997 • 613 citations

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum

2003 • 552 citations

Detection of Dopamine Dynamics in the Brain

1988 • 466 citations

Real-time characterization of dopamine overflow and uptake in the rat striatum

1988 • 420 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs implications for the origin of extracellular DOPAC

1988 • 378 citations

Transient changes in mesolimbic dopamine and their association with ‘reward’

2002 • 282 citations

Anti-hyperactivity medication: methylphenidate and amphetamine

1998 • 262 citations

Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine.

2001 • 262 citations

An In Vivo Study of Dopamine Release and Metabolism in Rat Brain Regions Using Intracerebral Dialysis

1986 • 261 citations

Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nomifensine and benztropine

1987 • 226 citations

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography

1992 • 211 citations

Stereoselective binding of 11C-raclopride in living human brain ? a search for extrastriatal central D2-dopamine receptors by PET

1988 • 202 citations

Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.

1993 • 183 citations

Effects of Blood Flow on [¹¹C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET Data

1994 • 171 citations

In vivo neurochemical profile of dopamine uptake inhibitors and releasers in rat caudate-putamen

1989 • 139 citations

Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans

1999 • 136 citations

Differentiation of Dopamine Overflow and Uptake Processes in the Extracellular Fluid of the Rat Caudate Nucleus with Fast-Scan In Vivo Voltammetry

1988 • 129 citations

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.

1993 • 128 citations

Ketamine decreased striatal [11C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: Multiparametric PET studies combined with microdialysis analysis

2000 • 128 citations

PET Measures of Amphetamine-Induced Dopamine Release in Ventral versus Dorsal Striatum

1999 • 124 citations

Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain

1999 • 121 citations

Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine.

1992 • 120 citations

Methylphenidate Redistributes Vesicular Monoamine Transporter-2: Role of Dopamine Receptors

2002 • 119 citations

Requirements and implementation of a flexible kinetic modeling tool.

1997 • 114 citations

Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine

2002 • 114 citations

Mapping muscarinic receptors in human and baboon brain using [N‐¹¹C‐methyl]‐benztropine

1990 • 113 citations

A 3D digital map of rat brain

1995 • 98 citations

Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor

2000 • 97 citations

Impact of psychostimulants on vesicular monoamine transporter function

2003 • 90 citations

Characterisation of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis

1991 • 87 citations

Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity.

2003 • 86 citations

Clinical psychopharmacology of AD/HD: Implications for animal models

2000 • 85 citations

Kinetic properties of the accumulation of 3H-raclopride in the mouse brain in vivo

1989 • 79 citations

Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain

1999 • 74 citations

The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate

2002 • 65 citations

Reserpine enhances amphetamine stereotypies without increasing amphetamine-induced changes in striatal dialysate dopamine

1989 • 65 citations

Differential effects of D- and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesis

1975 • 56 citations

Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response.

1997 • 53 citations

Use of Positron Emission Tomography to Study the Dynamics of Psychostimulant-Induced Dopamine Release

1997 • 48 citations

Stereoselective inhibition of dopaminergic activity by gamma vinyl-GABA following a nicotine or cocaine challenge: A pet/microdialysis study

2000 • 43 citations

Methylphenidate and pemoline do not cause depletion of rat brain monoamine markers similar to that observed with methamphetamine

1989 • 41 citations

Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats

1992 • 39 citations

Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging

2004 • 39 citations

Experimental Investigations on Dopamine Transmission Can Provide Clues on the Mechanism of the Therapeutic Effect of Amphetamine and Methylphenidate in ADHD

2000 • 34 citations

Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study

1991 • 32 citations

Positron Emission Tomography Radioligands for Dopamine Transporters and Studies in Human and Nonhuman Primates

1997 • 29 citations

Effects of Endogenous Neurotransmitters on the in vivo Binding of Dopamine and 5-HT Radiotracers in Mice

2001 • 28 citations

Biochemical Characterization of Dopamine Receptors

1997 • 22 citations

Anesthetics decreased the microdialysis extraction fraction of norepinephrine but not dopamine in the medial prefkontal cortex

1995 • 21 citations

Gamma Vinyl-GABA Differentially Modulates NMDA Antagonist-Induced Increases in Mesocortical Versus Mesolimbic DA Transmission

2001 • 20 citations

Endogenously released dopamine inhibits the binding of dopaminergic PET and SPECT ligands in superfused rat striatal slices

1996 • 20 citations

The Study of Neurotransmitter Interactions Using Positron Emission Tomography and Functional Coupling

1996 • 19 citations

Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation.

2002 • 17 citations

Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine binges

2001 • 13 citations

Dopamine Efflux Studies into in Vivo Actions of Psychostimulant Drugs

1997 • 4 citations