Venous Thrombosis: Prevalence and Interaction of Risk Factors

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

1996 • 3,124 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Venous thrombosis: a multicausal disease

1999 • 1,570 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

World distribution of factor V Leiden

1995 • 1,184 citations

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis

1995 • 1,117 citations

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

1994 • 1,065 citations

Inherited Antithrombin Deficiency Causing Thrombophilia

1965 • 1,040 citations

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

1995 • 1,036 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE

1994 • 987 citations

Geographic Distribution of the 20210 G to A Prothrombin Variant

1998 • 707 citations

Absence of Thrombosis in Subjects with Heterozygous Protein C Deficiency

1987 • 529 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 516 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study) [see comments]

1995 • 372 citations

Prevalence of antithrombin deficiency in the healthy population

1994 • 363 citations

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

1993 • 354 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

Prevalence of Protein C Deficiency in the Healthy Population

1995 • 328 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Risk factors for venous thrombosis: prevalence, risk, and interaction.

1997 • 221 citations

Hyperhomocysteinemia and Deep-Vein Thrombosis A Case-Control Study

1996 • 131 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1991 • 127 citations

Familial Clustering of Factor VIII and von Willebrand Factor Levels

1998 • 111 citations

The Relative Frequency of Hereditary Thrombotic Disorders Among 107 Patients with Thrombophilia in Israel

1989 • 106 citations

Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients

1996 • 86 citations

[Plasma homocysteine assay in the exploration of thrombosis in young subjects].

1991 • 27 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1992 • 13 citations

INCIDENCE OF DEFECTIVE T-PA RELEASE IN 158 UNRELATED YOUNG PATIENTS WITH VENOUS THROMBOSIS IN COMPARISON TO PC-, PS-, AT III-, FIBRINOGEN- AND PLASMINOGENDEFICIENCY

1987 • 9 citations