Endothelial Dysfunction After Repeated Chlamydia pneumoniae Infection in Apolipoprotein E–Knockout Mice

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

1996 • 851 citations

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.

1995 • 783 citations

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.

1994 • 632 citations

The Role of Endothelium in Cardiovascular Homeostasis and Diseases

1993 • 558 citations

Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.

1991 • 531 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Infection With Chlamydia pneumoniae Accelerates the Development of Atherosclerosis and Treatment With Azithromycin Prevents It in a Rabbit Model

1998 • 522 citations

Gene therapy inhibiting neointimal vascular lesion

1995 • 387 citations

Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions.

1992 • 339 citations

Interactive Role of Infection, Inflammation and Traditional Risk Factors in Atherosclerosis and Coronary Artery Disease 11This study was supported in part by a Merit Review grant from the Department of Veterans Affairs Central Office, Washington, D.C.

1998 • 323 citations

Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation.

1994 • 296 citations

Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice

1999 • 266 citations

Aspirin Improves Endothelial Dysfunction in Atherosclerosis

1998 • 263 citations

Murine Models ofChlamydia pneumoniaeInfection and Atherosclerosis

1997 • 250 citations

Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits

1997 • 236 citations

Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors.

1993 • 232 citations

Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.

1995 • 217 citations

Thromboatherosclerosis in normolipemic rabbits. A result of continued endothelial damage.

1973 • 200 citations

Atherosclerosis, Vascular Remodeling, and Impairment of Endothelium-Dependent Relaxation in Genetically Altered Hyperlipidemic Mice

1997 • 172 citations

Confirmed Previous Infection With Chlamydia pneumoniae (TWAR) and Its Presence in Early Coronary Atherosclerosis

1998 • 168 citations

Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice.

1999 • 168 citations

St Cyres lecture. Endothelium in control.

1991 • 164 citations

The physiology and pathophysiology of the nitric oxide/superoxide system

1997 • 147 citations

Role of Innate and Adaptive Immunity in the Outcome of Primary Infection withChlamydia pneumoniae, as Analyzed in Genetically Modified Mice

1999 • 128 citations

Pathogenetic mechanisms and epidemiology of Chlamydia pneumoniae.

1993 • 123 citations

Interaction of Chlamydia pneumoniae and Human Alveolar Macrophages: Infection and Inflammatory Response

1998 • 121 citations

Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation.

1996 • 105 citations

Ex vivo assay to determine the cyclooxygenase selectivity of non‐steroidal anti‐inflammatory drugs

1999 • 88 citations

Temperature-controlled radiofrequency catheter ablation of AV conduction: first clinical experience

1993 • 85 citations

Chlamydia pneumoniae and atherosclerosis--an update.

1997 • 64 citations

Regulation of Cyclooxygenase-2 and Endogenous Cytokine Expression by Bacterial Lipopolysaccharide That Acts in Synergy with c-Kit Ligand and Fcε Receptor I Crosslinking in Cultured Mast Cells

1998 • 45 citations

Infection-associated intimal thickening in the coronary arteries of children

1999 • 41 citations

Is infection with Chlamydia pneumoniae a causative agent in atherosclerosis?

1998 • 41 citations

Impairment of Endothelium-Dependent Arterial Relaxation By High-Fat Feeding in ApoE-Deficient Mice

1999 • 40 citations

Nitric oxide synthesis in atherosclerosis

1998 • 33 citations

Effect of Short-term Regression of Atherosclerosis on Reactivity of Carotid and Retinal Arteries

1996 • 20 citations

Effects of aspirin on endothelial dysfunction in atherosclerosis

1998 • 18 citations

Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta

1998 • 13 citations

Cellular Source in Ewes of Prostaglandin-Endoperoxide Synthase-2 in Uterine Arteries Following Stimulation with Lipopolysaccharide1

1999 • 13 citations

Time-Dependent Inhibition of Prostaglandins Synthesis by Nonsteroidal Antiinflammatory Drugs; Time-Dependent Alteration of Inhibitory Effect and Characteristics of its Active Site

1984 • 7 citations

Effects of aspirin on endothelial dysfunction in atherosclerosis

1998 • 6 citations

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