Extensive‐stage small‐cell lung cancer

Randomized Trial of Dose-Dense Versus Conventionally Scheduled and Sequential Versus Concurrent Combination Chemotherapy as Postoperative Adjuvant Treatment of Node-Positive Primary Breast Cancer: First Report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741

2003 • 1,525 citations

Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer

1991 • 1,401 citations

Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung Cancer

2002 • 1,346 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell Lung Cancer

1999 • 909 citations

The importance of dose intensity in chemotherapy of metastatic breast cancer.

1984 • 882 citations

Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group.

1992 • 532 citations

Keynote address on biostatistics and data retrieval.

1973 • 476 citations

Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group.

1997 • 474 citations

Randomized Trial of Cyclophosphamide, Doxorubicin, and Vincristine Versus Cisplatin and Etoposide Versus Alternation of These Regimens in Small-Cell Lung Cancer

1991 • 444 citations

The Norton-Simon hypothesis revisited.

1986 • 415 citations

Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer—what limits limited disease?

2002 • 384 citations

Twenty Years of Phase III Trials for Patients With Extensive-Stage Small-Cell Lung Cancer: Perceptible Progress

1999 • 351 citations

Neuroprotective Effect of Vitamin E Supplementation in Patients Treated With Cisplatin Chemotherapy

2003 • 313 citations

Topotecan Versus Observation After Cisplatin Plus Etoposide in Extensive-Stage Small-Cell Lung Cancer: E7593—A Phase III Trial of the Eastern Cooperative Oncology Group

2001 • 289 citations

Is there a case for cisplatin in the treatment of small-cell lung cancer? A meta-analysis of randomized trials of a cisplatin-containing regimen versus a regimen without this alkylating agent

2000 • 282 citations

Staging and prognostic factors in small cell lung cancer: a consensus report

1989 • 256 citations

Prospective randomized comparison of high-dose and standard-dose etoposide and cisplatin chemotherapy in patients with extensive-stage small-cell lung cancer.

1994 • 252 citations

A systematic review of the role of etoposide and cisplatin in the chemotherapy of small cell lung cancer with methodology assessment and meta-analysis

2000 • 249 citations

Initial Chemotherapeutic Doses and Survival in Patients with Limited Small-Cell Lung Cancer

1993 • 249 citations

Superiority of Alternating Non-Cross-Resistant Chemotherapy in Extensive Small Cell Lung Cancer

1987 • 227 citations

Comparison of oral etoposide and standard intravenous multidrug chemotherapy for small-cell lung cancer: a stopped multicentre randomised trial

1996 • 226 citations

Small Cell Lung Cancer*

2003 • 219 citations

Prolonged administration of oral etoposide in patients with relapsed or refractory small-cell lung cancer: a phase II trial.

1990 • 217 citations

A randomized combined modality trial in small cell carcinoma of the lung comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation

1980 • 210 citations

Five-Day Oral Etoposide2 Treatment for Advanced Small-Cell Lung Cancer: Randomized Comparison With Intravenous Chemotherapy

1997 • 208 citations

Late intensification chemotherapy with autologous bone marrow transplantation in selected small-cell carcinoma of the lung: a randomized study.

1987 • 204 citations

Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small-cell lung cancer.

1985 • 188 citations

Etoposide Plus Cisplatin With or Without the Combination of 4'-Epidoxorubicin Plus Cyclophosphamide in Treatment of Extensive Small-Cell Lung Cancer: a French Federation of Cancer Institutes Multicenter Phase III Randomized Study

2001 • 171 citations

Duration of chemotherapy in small cell lung cancer: a Cancer Research Campaign trial

1989 • 170 citations

Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin.

1999 • 166 citations

A multicenter randomized clinical trial comparing paclitaxel–cisplatin–etoposide versus cisplatin–etoposide as first-line treatment in patients with small-cell lung cancer

2001 • 159 citations

Cisplatin plus etoposide with and without ifosfamide in extensive small-cell lung cancer: a Hoosier Oncology Group study.

1995 • 157 citations

Maintenance chemotherapy in small-cell lung cancer: long-term results of a randomized trial. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.

1993 • 148 citations

Dose-intensity meta-analysis of chemotherapy regimens in small-cell carcinoma of the lung.

1991 • 136 citations

Teniposide in the treatment of small-cell lung cancer: the influence of prior chemotherapy.

1988 • 131 citations

Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer.

1988 • 125 citations

Reinduction chemotherapy in small cell lung cancer

1987 • 121 citations

Combined modality induction therapy without maintenance chemotherapy for small cell carcinoma of the lung.

1984 • 114 citations

A randomized comparison of standard chemotherapy versus alternating chemotherapy and maintenance versus no maintenance therapy for extensive-stage small-cell lung cancer: a phase III study of the Eastern Cooperative Oncology Group.

1990 • 103 citations

The influence of age on the delivery, tolerance, and efficacy of thoracic irradiation in the combined modality treatment of limited stage small cell lung cancer

1999 • 97 citations

Maintenance chemotherapy for small cell lung cancer: a critical review of the literature

1998 • 94 citations

Cisplatin/etoposide versus carboplatin/etoposide chemotherapy and irradiation in small cell lung cancer: a randomized phase III study. Hellenic Cooperative Oncology Group for Lung Cancer Trials.

1994 • 88 citations

Treatment of small cell lung carcinoma in the elderly

1996 • 85 citations

Phase II trial of daily oral VP-16 in refractory small cell lung cancer: a Hoosier Oncology Group study.

1990 • 83 citations

Incidence of neutropenic fever in patients treated with standard-dose combination chemotherapy for small-cell lung cancer and the cost impact of treatment with granulocyte colony-stimulating factor.

1994 • 72 citations

European organization for research and treatment of cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer.

2003 • 70 citations

VP-16 alone and in combination with cisplatin in previously treated patients with small cell lung cancer

1984 • 68 citations

Maintenance daily oral etoposide versus no further therapy following induction chemotherapy with etoposide plus ifosfamide plus cisplatin in extensive small-cell lung cancer:a Hoosier Oncology Group randomized study

2002 • 66 citations

Maintenance chemotherapy for anaplastic small cell carcinoma of the bronchus: A randomised, controlled trial

1986 • 64 citations

Role of granulocyte and granulocyte-macrophage colony-stimulating factors in the treatment of small-cell lung cancer: a systematic review of the literature with methodological assessment and meta-analysis

2002 • 51 citations

Cyclic-alternating versus response-oriented chemotherapy in small-cell lung cancer: a German multicenter randomized trial of 321 patients.

1991 • 50 citations

Routine use of granulocyte colony-stimulating factor is not cost-effective and does not increase patient comfort in the treatment of small-cell lung cancer: an analysis using a Markov model.

1998 • 49 citations

Superiority of cisplatin or carboplatin in combination with teniposide and vincristine in the induction chemotherapy of small-cell lung cancer. A randomized trial with 5 years follow up

1996 • 49 citations

Small-Cell Lung Cancer: State of the Art

2002 • 44 citations

Justification for Evaluating New Anticancer Drugs in Selected Untreated Patients With Extensive-Stage Small-Cell Lung Cancer: An Eastern Cooperative Oncology Group Randomized Study

1992 • 42 citations

Improvement of long-term survival in extensive small-cell lung cancer.

1988 • 39 citations

Extensive-stage small-cell bronchogenic carcinoma: intensive induction chemotherapy with high-dose cyclophosphamide plus high-dose etoposide.

1985 • 38 citations

Carboplatin in the Treatment of Small Cell Lung Cancer

1998 • 38 citations

Maintenance chemotherapy in limited small cell lung cancer: a randomised controlled clinical trial

1989 • 35 citations

Phase II trial of daily oral VP-16 in refractory small cell lung cancer: a Hoosier Oncology Group study

1990 • 33 citations

A Phase II study of all-trans-retinoic acid plus cisplatin and etoposide in patients with extensive stage small cell lung carcinoma

1998 • 31 citations

Paclitaxel, carboplatin, and topotecan in the treatment of patients with small cell lung carcinoma

2002 • 29 citations

Integrating Palliative Care in Oncology

2001 • 28 citations

Standard- and high-dose etoposide, ifosfamide, carboplatin, and epirubicin in 100 patients with small-cell lung cancer: A mature follow-up report

1999 • 24 citations

Early versus late alternating chemotherapy in small-cell lung cancer

1995 • 22 citations

Dose intensity of initial chemotherapy may have an impact on survival in limited small cell lung carcinoma

1993 • 19 citations

A phase II randomised trial comparing the cisplatin–etoposide combination chemotherapy with or without carboplatin as second-line therapy for small-cell lung cancer

2002 • 19 citations

Standard combination versus alternating chemotherapy in small cell lung cancer

1999 • 18 citations

High-dose chemotherapy in small-cell lung cancer.

2003 • 17 citations

Autologous stem cell transplantation for small cell lung cancer

2002 • 16 citations

High-dose Chemotherapy in Small Cell Lung Cancer

2002 • 15 citations

Dose intensity in small cell lung cancer.

1998 • 10 citations

Should maintenance chemotherapy be used to treat small cell lung cancer? Pro:

1998 • 5 citations

267 Tolerability of dose-intensive ICE chemotherapy for SCLC with filgrastim and reinfusion of haemopoietic progenitors in whole blood

1997 • 2 citations

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