A probe of the active site acidity of carboxypeptidase A

Methods of Enzymatic Analysis

1975 • 20,446 citations

Interactions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systems

1974 • 1,099 citations

Fast elementary steps in chemical reaction mechanisms

1963 • 516 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Determining the Chemical Mechanisms of Enzyme‐Catalyzed Reactions by Kinetic Studies

1977 • 340 citations

Mechanism of the aminolysis of acetate esters

1974 • 320 citations

Metallocarboxypeptidases: Stability Constants and Enzymatic Characteristics

1961 • 222 citations

Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

1973 • 193 citations

Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis

1985 • 117 citations

Kinetics of carboxypeptidase A. pH dependence of tripeptide hydrolysis catalyzed by zinc, cobalt, and manganese enzymes

1970 • 105 citations

Catalytic role of the metal ion of carboxypeptidase A in ester hydrolysis.

1979 • 104 citations

Spectral properties of cobalt carboxypeptidase. Effects of substrates and inhibitors

1971 • 96 citations

Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution.

1981 • 78 citations

General acid and general base catalysis of the methoxyaminolysis of 1-acetyl-1,2,4-triazole

1974 • 68 citations

Relationship of the three dimensional structure of carboxypeptidase A to catalysis

1974 • 64 citations

Affinity labeling of bovine carboxypeptidase A γLeu by N-bromoacetyl-N-methyl-L-phenylalanine. I. Kinetics of inactivation

1971 • 55 citations

Diffusion-controlled proton transfer in intramolecular thiol ester aminolysis and thiazoline hydrolysis

1969 • 52 citations

Cryokinetic studies of the intermediates in the mechanism of carboxypeptidase A

1983 • 43 citations

Estimation of the dissociation constants of enzyme-substrate complexes from steady-state measurements. Interpretation of pH-independence of Km

1976 • 42 citations

Hydrolysis of a thiopeptide by cadmium carboxypeptidase A

1981 • 41 citations

Models for cobalt(II)-substituted zinc metalloenzymes. 2. Comparisons of the crystal structures of complexes of the type [M(RCOO)2(2-X-Im)2] (Im = imidazole; M = Co, Zn; R = CH3, C2H5, C3H7; X = CH3, C2H5). An unusual type of linkage isomerism

1982 • 36 citations

コバルト(II)置換亜鉛メタロ酵素に対するモデル II 〔M(RCOO) 2 (2-X-Im) 2 〕 (Im=イミダゾール;M=Co,Zn;R=Me,Et,Pr;X=Me,Et)型錯体の結晶構造の比較 結合異性の異常な型

1982 • 31 citations

Versuche zur Synthese des Chromenols und seiner Derivate

1909 • 29 citations

Spectral properties of cobalt carboxypeptidase A. Interaction of the metal atom with anions

1983 • 29 citations

Enzymatically inactive, exchange-inert cobalt(III)-carboxypeptidase A: role of inner sphere coordination in peptide and ester catalysis

1978 • 28 citations

Extreme state of ionization of benzylsuccinate bound by carboxypeptidase A

1982 • 25 citations

Chlorine-35 nuclear magnetic resonance investigation of carboxypeptidase A

1974 • 25 citations

Kinetics of Formation and Dissociation of Metallocarboxypeptidases

1978 • 25 citations

Novel structure of the complex between carboxypeptidase A and a ketonic substrate analog

1985 • 24 citations

The unreliability of estimates of group dissociation constants

1976 • 23 citations

Torsional-strain considerations in enzymology

1976 • 19 citations

The pH dependency of the zinc and cobalt carboxypeptidase catalyzed enolization of (R)-2-benzyl-3-(p-methoxybenzoyl)propionic acid

1983 • 17 citations

The pH dependence of peptide hydrolysis by nitrocarboxypeptidase A

1980 • 15 citations

Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies.

1984 • 13 citations

Effects of metal ion substitution on carboxypeptidase A catalyzed hydrolysis of O-(trans-cinnamoyl)-L-.beta.-phenyllactate

1983 • 11 citations

XCII.—A new method for the determination of hydrolytic dissociation

1901 • 7 citations