Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Interleukin-10

1993 • 1,820 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function

1999 • 248 citations

Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor

1993 • 239 citations

Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.

1996 • 227 citations

Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws

1999 • 204 citations

Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.

1995 • 190 citations

Human Glioma-derived Interleukin-10 Inhibits Antitumor Immune Responses In Vitro

1995 • 160 citations

Antimetastatic and Antitumor Activities of Interleukin 10 in a Murine Model of Breast Cancer

1996 • 157 citations

Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis.

1996 • 151 citations

Interleukin 10 production by human melanoma.

1996 • 113 citations

Interleukin 10 (IL-10): an immunosuppressive factor and independent predictor in patients with metastatic renal cell carcinoma

1999 • 88 citations

Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors

2000 • 84 citations

Loss of Tumorigenicity and Increased Immunogenicity Induced by Interleukin-10 Gene Transfer in B16 Melanoma Cells

1996 • 83 citations

IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response

1999 • 66 citations

Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation

1999 • 64 citations

Cytokine Therapy for Cancer

2000 • 61 citations

IL-10 Inhibits Alloreactive Cytotoxic T Lymphocyte Generation in Vivo

1994 • 57 citations

Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells

2000 • 46 citations

Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide

1998 • 38 citations

Interleukin-10 gene transfer activates interferon-? and the interferon-?-inducible genesGbp-1/Mag-1 andMig-1 in mammary tumors

1999 • 21 citations

Antimestatic and antitumor activities of interleukin 10 in transfected human prostate PC-3 ML clones: Orthotopic growth in severe combined immunodeficient mice.

1998 • 17 citations

Murine colon carcinoma cells engineered to produce human interleukin-2 induce tumor-specific anti-tumor response

1996 • 14 citations

Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells

1996 • 13 citations