Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

DNA VACCINES

1997 • 977 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

PKR; a sentinel kinase for cellular stress

1999 • 823 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand

1998 • 490 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

DNA and RNA-based vaccines: principles, progress and prospects

1999 • 389 citations

Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4⁺T lymphocytes

1999 • 383 citations

Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

1997 • 352 citations

Cancer therapy using a self-replicating RNA vaccine

1999 • 322 citations

Fc receptors are required in passive and active immunity to melanoma

1998 • 322 citations

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

2001 • 307 citations

The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation

1998 • 259 citations

Coupling and Uncoupling of Tumor Immunity and Autoimmunity

1999 • 245 citations

Enhancing immune responses using suicidal DNA vaccines

1998 • 241 citations

Tumor immunity and autoimmunity induced by immunization with homologous DNA.

1998 • 233 citations

Immunization of non-human primates with DNA vaccines

1997 • 223 citations

Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity

2002 • 208 citations

The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.

1990 • 203 citations

Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer

1996 • 194 citations

Self-replicating Semliki Forest virus RNA as recombinant vaccine

1994 • 189 citations

DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector

1998 • 183 citations

Enhancement of tumor-specific immune response with plasmid DNA replicon vectors.

2000 • 157 citations

Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells

2001 • 156 citations

Quantitative Analysis of Eumelanin and Pheomelanin in Hair and Melanomas

1983 • 132 citations

Targeted antigen delivery to antigen–presenting cells including dendritic cells by engineered Fas-mediated apoptosis

2000 • 126 citations

Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases

2001 • 125 citations

Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites.

1997 • 123 citations

Replicon Vectors Derived from Sindbis Virus and Semliki Forest Virus That Establish Persistent Replication in Host Cells

2000 • 121 citations

The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR

2000 • 115 citations

Inhibition of Apoptosis by the African Swine Fever Virus Bcl-2 Homologue: Role of the BH1 Domain

1997 • 103 citations

A sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expressionin vivo

1995 • 100 citations

A Plasmid-Based Self-Amplifying Sindbis Virus Vector

1995 • 96 citations

Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1

1997 • 96 citations

Alphavirus vectors: development and potential therapeutic applications

2001 • 86 citations

Dead or alive: immunogenicity of human melanoma cells when presented by dendritic cells.

2000 • 85 citations

The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors

1999 • 60 citations

Antigen-presenting cells and the selection of immunodominant epitopes.

1997 • 38 citations

Nucleic Acid for the Treatment of Cancer: Genetic Vaccines and DNA Adjuvants

2001 • 32 citations

Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.

2002 • 27 citations

Generation of polyclonal rabbit antisera to mouse melanoma associated antigens using gene gun immunization

1998 • 14 citations