Curative effects of recombinant human Interleukin-6 in DA rats with protracted relapsing experimental allergic encephalomyelitis

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis

1993 • 572 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Defective inflammatory response in interleukin 6-deficient mice.

1994 • 540 citations

T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

1994 • 519 citations

IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

1998 • 448 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1998 • 307 citations

Genetic Absence of γ-Interferon Delays but Does Not Prevent Diabetes in NOD Mice

1996 • 244 citations

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein

1998 • 229 citations

Animal models of human disease Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease

1995 • 218 citations

Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis

1997 • 201 citations

IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha.

1996 • 163 citations

IL-6 detection in multiple sclerosis brain

1997 • 160 citations

Interferon γ, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in lewis rats: Dynamics of cellular mrna expression in the central nervous system and lymphoid cells

1995 • 159 citations

Interleukin‐6 functions in autoimmune encephalomyelitis: a study in gene‐targeted mice

1998 • 156 citations

The cytokine storm in multiple sclerosis

1998 • 153 citations

Immunologic Mechanisms and Therapy in Multiple Sclerosis

1995 • 147 citations

Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation

1995 • 145 citations

Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice

1998 • 143 citations

Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant

1995 • 142 citations

IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glycoprotein 35–55 induced experimental autoimmune encephalomyelitis

1999 • 135 citations

Interleukin-6 is elevated in plasma in multiple sclerosis

1991 • 129 citations

Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.

1994 • 116 citations

Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β

1996 • 112 citations

Cytokines and Murine Autoimmune Encephalomyelitis: Inhibition or Enhancement of Disease with Antibodies to Select Cytokines, or by Delivery of Exogenous Cytokines Using a Recombinant Vaccinia Virus System

1995 • 95 citations

Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice

1996 • 86 citations

Role of Interleukin 6 and Transforming Growth Factor–β in the Induction of Depressed Splenocyte Responses Following Sepsis

1993 • 81 citations

The cytokine storm in multiple sclerosis

1998 • 75 citations

High IL-6 and Low IL-10 in the Central Nervous System Are Associated with Protracted Relapsing EAE in DA Rats

1997 • 75 citations

The major histocompatibility complex influences myelin basic protein 63‐88‐induced T cell cytokine profile and experimental autoimmune encephalomyelitis

1993 • 71 citations

The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse.

1996 • 69 citations

Interleukin 6 inhibits delayed‐type hypersensitivity and the development of adjuvant arthritis

1991 • 68 citations

Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice

1994 • 58 citations

Prevention of Spontaneous Autoimmune Diabetes in Diabetes-Prone BB Rats by Prophylactic Treatment with Antirat Interferon-γ Antibody

1997 • 52 citations

Paradoxical Antidiabetogenic Effect of γ-Interferon in DP-BB Rats

1998 • 38 citations

Injection Time of Interleukin-6 Determines Fatal Outcome in Experimental Endotoxin Shock

1996 • 38 citations

Variations of IL2, IL6, TNF alpha plasmatic levels in relapsing remitting multiple sclerosis.

1997 • 35 citations

Multiple sclerosis: a unique immunopathological syndrome of the central nervous system

1995 • 23 citations

The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse

1996 • 20 citations

Prevention of Spontaneous Autoimmune Diabetes in Diabetes-Prone BB Rats by Prophylactic Treatment with Antirat Interferon- Antibody

1997 • 16 citations

Paradoxical antidiabetogenic effect of gamma-interferon in DP-BB rats

1998 • 13 citations

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