Evolutionary Development of the B‐Cell Repertoire^a

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

1987 • 693 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

The Immune System of Xenopus

1989 • 261 citations

Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution

1986 • 223 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate.

1988 • 181 citations

Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate.

1988 • 122 citations

Immunoglobulin VH gene structure and diversity in Heterodontus, a phylogenetically primitive shark.

1985 • 98 citations

Genomic organization and sequences of immunoglobulin light chain genes in a primitive vertebrate suggest coevolution of immunoglobulin gene organization.

1989 • 91 citations

Complete nucleotide sequence of an immunoglobulin heavy-chain gene and analysis of immunoglobulin gene organization in a primitive teleost species.

1990 • 90 citations

Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish,Raja erinacea

1990 • 88 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

Immunoglobulin heavy chain gene organization and complexity in the skate,Raja erinacea

1990 • 65 citations

Genetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity.

1989 • 62 citations

Heavy chain variable region gene families evolved early in phylogeny. Ig complexity in fish.

1991 • 60 citations

Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis.

1990 • 58 citations

Nucleotide sequence of a cDNA encoding a third distinctXenopusimmunoglobulin heavy chain isotype

1989 • 51 citations

Complete nucleotide sequence of an immunoglobulin VH gene homologue from Caiman, a phylogenetically ancient reptile

1983 • 50 citations

Characterization of immunoglobulin from the Pacific hagfish, a primitive vertebrate

1978 • 45 citations

A serum heterodimer from hagfish (Eptatretus stoutii) exhibits structural similarity and partial sequence identity with immunoglobulin.

1991 • 40 citations

A secondXenopusimmunoglobulin heavy chain constant region isotype gene

1989 • 37 citations

The genomic organization of immunoglobulin VHgenes inXenopus laevisshows evidence for interspersion of families

1991 • 27 citations

Isolation and characterization of immunoglobulin of hagfish, Eptatretus burgeri, a primitive vertebrate

1985 • 25 citations