Quinacrine and ethidium bind to different loci on the Torpedo acetylcholine receptor

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

[24] Nanosecond fluorescence spectroscopy of macromolecules

1972 • 294 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Intramolecular quenching of excited singlet states by stable nitroxyl radicals

1990 • 242 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Acetylcholine receptor kinetics

1981 • 223 citations

Annular and nonannular binding sites for cholesterol associated with the nicotinic acetylcholine receptor

1988 • 200 citations

Lipid-protein interactions in reconstituted membranes containing acetylcholine receptor

1983 • 189 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata.

1978 • 182 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

The Permeation Pathway of Neurotransmitter-Gated Ion Channels

1992 • 142 citations

Fluorescence quenching in model membranes. 1. Characterization of quenching caused by a spin-labeled phospholipid

1981 • 134 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

The noncompetitive blocker [³H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit

1989 • 99 citations

Distance between the Agonist and Noncompetitive Inhibitor Sites on the Nicotinic Acetylcholine Receptor

1989 • 85 citations

Solute accessibility to N epsilon-fluorescein isothiocyanate-lysine-23 cobra alpha-toxin bound to the acetylcholine receptor. A consideration of the effect of rotational diffusion and orientation constraints on fluorescence quenching

1985 • 82 citations

Luminescence quenching by nitroxide spin labels in aqueous solution: studies on the mechanism of quenching

1992 • 71 citations

Acetylcholine receptor and ionic channel of Torpedo electroplax: binding of perhydrohistrionicotoxin to membrane and solubilized preparations

1978 • 66 citations

Interaction of noncompetitive inhibitors with the acetylcholine receptor. The site specificity and spectroscopic properties of ethidium binding.

1987 • 60 citations

Molecular sites of anestheticaction in postsynaptic nicotinic membranes

1989 • 53 citations

Quinacrine binds to the lipid-protein interface of the Torpedo acetylcholine receptor: a fluorescence study.

1992 • 37 citations

Reaction of [3H]meproadifen mustard with membrane-bound Torpedo acetylcholine receptor.

1986 • 28 citations

Distinctions in Ligand Binding Sites on the Nicotinic Acetylcholine Receptor^a

1991 • 22 citations

Transverse localization of the quinacrine binding site on the Torpedo acetylcholine receptor.

1993 • 21 citations

Channel permeant cations compete selectively with noncompetitive inhibitors of the nicotinic acetylcholine receptor.

1991 • 19 citations

Steric factors limit access to the noncompetitive inhibitor site of the nicotinic acetylcholine receptor. Fluorescence studies

1992 • 12 citations

Modulation of phencyclidine-sensitive ethidium binding to the Torpedo acetylcholine receptor: interaction of noncompetitive inhibitors with carbamylcholine and cobra alpha-toxin.

1992 • 7 citations