Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

A transient calcium‐dependent chloride current in the immature Xenopus oocyte.

1983 • 627 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Protein incorporation by isolated amphibian oocytes III. Optimum incubation conditions

1973 • 487 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain.

1983 • 332 citations

Functional Architecture of the Nicotinic Acetylcholine Receptor: From Electric Organ to Brain

1991 • 327 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes.

1990 • 309 citations

Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways

1993 • 286 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Neurotransmitter action: Opening of ligand-gated ion channels

1993 • 267 citations

Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels

1990 • 260 citations

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

1992 • 238 citations

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.

1990 • 193 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor

1992 • 141 citations

Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes

1987 • 129 citations

Chapter 11 Fertilization of Cultured Xenopus Oocytes and Use in Studies of Maternally Inherited Molecules

1991 • 118 citations

Threonine in the selectivity filter of the acetylcholine receptor channel

1992 • 112 citations

Desensitization of the acetylcholine receptor of frog end‐plates measured in a Vaseline‐gap voltage clamp.

1989 • 97 citations

Transmembrane topology of acetylcholine receptor subunits probed with photoreactive phospholipids

1985 • 81 citations

Properties of proteoliposomes reconstituted with acetylcholine receptor from Torpedo californica.

1982 • 80 citations

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

1992 • 80 citations

The sidedness of the COOH terminus of the acetylcholine receptor δ subunit

1989 • 69 citations

The nicotinic acetylcholine receptor

1981 • 60 citations

Correlation of phospholipid structure with functional effects on the nicotinic acetylcholine receptor. A modulatory role for phosphatidic acid

1993 • 56 citations

Three possible disulfides in the acetylcholine receptor alpha-subunit.

1988 • 55 citations

Site-specific mutations of nicotinic acetylcholine receptor at the lipid-protein interface dramatically alter ion channel gating

1992 • 49 citations

Activation of skeletal muscle nicotinic acetylcholine receptors

1992 • 47 citations

Functional role of the cysteine 451 thiol group in the M4 helix of the .gamma. subunit of Torpedo californica acetylcholine receptor

1990 • 43 citations

Role of a key cysteine residue in the gating of the acetylcholine receptor

1991 • 41 citations

FTIR analysis of nicotinic acetylcholine receptor secondary structure in reconstituted membranes

1993 • 38 citations

Use of chemical modifications and site-directed mutagenesis to probe the functional role of thiol groups on the .gamma. subunit of Torpedo californica acetylcholine receptor

1989 • 29 citations

Labeling of functionally sensitive sulfhydryl-containing domains of acetylcholine receptor from Torpedo californica membranes.

1986 • 21 citations

Covalent modification of a critical sulfhydryl group in the acetylcholine receptor: cysteine-222 of the .alpha.-subunit

1989 • 21 citations

Thiol-group modification of Torpedo californica acetylcholine receptor: subunit localization and effects on function

1986 • 19 citations