The anti-estrogen tamoxifen blocks the stimulatory effects of interleukin-6 on 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

The pharmacology and clinical uses of tamoxifen

1984 • 873 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

1982 • 393 citations

Diamond genesis in a multiply-constrained model

1986 • 294 citations

Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells.

1983 • 288 citations

Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women

1986 • 249 citations

Tamoxifen induces accumulation of MCF 7 human mammary carcinoma cells in the G0/G1 phase of the cell cycle

1983 • 208 citations

Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens

1987 • 205 citations

THE RELATIONSHIP BETWEEN 17β‐HYDROXYSTEROID DEHYDROGENASE ACTIVITY AND OESTROGEN CONCENTRATIONS IN HUMAN BREAST TUMOURS AND IN NORMAL BREAST TISSUE

1983 • 188 citations

Pharmacology and Clinical Uses of Inhibitors of Hormone Secretion and Action

1988 • 188 citations

Progestin Effect on Cell Proliferation and 17β-Hydroxysteroid Dehydrogenase Activity in Normal Human Breast Cells in Culture*

1986 • 175 citations

Differential sensitivity of human breast cancer cell lines to the growth-inhibitory effects of tamoxifen.

1985 • 171 citations

Estrogenic activity of phenol red

1988 • 157 citations

Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens.

1981 • 138 citations

Autocrine and paracrine growth regulation of human breast cancer

1986 • 135 citations

Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity of MCF-7 cells in culture

1988 • 82 citations

Interleukin 6 is secreted by breast fibroblasts and stimulates 17β‐oestradiol oxidoreductase activity of MCF‐7 cells: Possible paracrine regulation of breast 17β‐oestradiol levels

1991 • 77 citations

The antiproliferative effect of tamoxifen in breast cancer cells: mediation by the estrogen receptor

1984 • 71 citations

Paracrine influence of human breast stromal fibroblasts on breast epithelial cells: Secretion of a polypeptide which stimulates reductive 17β‐oestradiol dehydrogenase activity

1988 • 64 citations

17β-Hydroxysteroid Dehydrogenase Activity in Human Breast Epithelial Cell and Fibroblast Cultures

1984 • 64 citations

Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7

1988 • 62 citations

Cytokines as biological response modifiers.

1992 • 52 citations

Cellular and molecular mechanism of action of antiestrogens

1983 • 49 citations

Mechanisms of Steroid Action

1981 • 39 citations

The response of breast cancer cells to steroid and peptide growth factors.

1992 • 28 citations

Metabolism of [3H]oestradiol in vivo by normal breast and tumour tissue in postmenopausal women

1986 • 27 citations

Interactive effects of interleukin-6, 17β-estradiol and progesterone on growth and 17β-hydroxysteroid dehydrogenase activity in human breast carcinoma cells

1993 • 23 citations

Mechanism of Action of High-Affinity Antiestrogens An Overview

1991 • 15 citations

Pharmacology of Tamoxifen

1980 • 5 citations

5. Human breast-cancer growth and progression: Role of secreted polypeptide growth factors

1990 • 2 citations