Cellular and molecular mechanism of action of antiestrogens

The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.

1976 • 820 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen*

1978 • 407 citations

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

1982 • 393 citations

High-affinity anti-oestrogen binding site distinct from the oestrogen receptor

1980 • 360 citations

Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

1978 • 348 citations

Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues.

1981 • 235 citations

Monoclonal antibodies to estrophilin: probes for the study of estrogen receptors.

1980 • 208 citations

Estrogen receptor · anti-estrogen complex: Atypical binding by uterine nuclei and effects on uterine growth

1973 • 195 citations

Isolation and characterization of a tamoxifen-resistant cell line derived from MCF-7 human breast cancer cells.

1981 • 145 citations

Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat

1977 • 131 citations

Inhibition of uterine estrogen receptor transformation by sodium molybdate.

1980 • 121 citations

High-affinity binding to the estrogen receptor of [3H]4-hydroxytamoxifen, an active antiestrogen metabolite

1980 • 117 citations

Formation of estrogen nuclear receptor in uterus: Effect of androgens, estrone and nafoxidine

1972 • 111 citations

Differences between oestrogen receptor activation by oestrogen and antioestrogen

1981 • 109 citations

Pharmacological modulation of steroid action

1980 • 97 citations

Non-Steroidal Antioestrogens

1983 • 72 citations

Interaction of a high affinity anti-estrogen (alpha-[4-pyrrolidinoethoxy]phenyl-4-hydroxy-alpha'-nitrostilbene, CI628M) with uterine estrogen receptors.

1981 • 71 citations

Estrogen-Receptor-DNA Interaction

2005 • 43 citations

Absence of correlation between antiestrogenic activity and binding affinity for the estrogen receptor

1979 • 43 citations

Estradiol dependent decrease of binding inhibition by anti-estrogens (a possible test of receptor activation)

1977 • 34 citations

Induction of two estrogen-responsive proteins by antiestrogens in R27, a tamoxifen-resistant clone of MCF7 cells.

1984 • 27 citations

Mechanism of action of antiestrogens and androgens on the estrogen receptor

1979 • 20 citations

Mode of action of LN 1643 (a triphenylbromoethylene antiestrogen): Probable mediation by the estrogen receptor and high affinity metabolite

1982 • 19 citations

Hormone and anti-hormone action at the target cell

1976 • 18 citations

SERUM 5α-ANDROSTANE-3α,17β-DIOL, ANDROSTERONE AND TESTOSTERONE CONCENTRATIONS IN THE IMMATURE MALE RAT: INFLUENCE OF TIME OF DAY

1977 • 10 citations

10. Impaired nuclear translocation and regulation: a possible explanation of anti-estrogenic activity

1975 • 8 citations