Dendritic cells and the regulation of the allergic immune response

Dendritic cells and the control of immunity

1998 • 14,345 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Asthma and Wheezing in the First Six Years of Life

1995 • 3,773 citations

Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children

2002 • 1,810 citations

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Allergy, Parasites, and the Hygiene Hypothesis

2002 • 1,543 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

2002 • 1,172 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

A Polymorphism* in the 5 ′ Flanking Region of the CD14 Gene Is Associated with Circulating Soluble CD14 Levels and with Total Serum Immunoglobulin E

1999 • 861 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen

2004 • 782 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

Asthma: an epidemic of dysregulated immunity

2002 • 613 citations

A Novel Host-Parasite Lipid Cross-talk

2002 • 587 citations

Severity of asthma is related to endotoxin in house dust.

1996 • 586 citations

IL-13 receptors and signaling pathways: An evolving web

2003 • 571 citations

Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study

2001 • 569 citations

Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

1995 • 557 citations

Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes

2000 • 554 citations

Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.

1993 • 540 citations

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

2000 • 513 citations

Increase in asthma: a more toxic environment or a more susceptible population?

1994 • 483 citations

The role of allergy in the development of asthma

1999 • 481 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

T cell fitness determined by signal strength

2003 • 478 citations

Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice.

1989 • 433 citations

Parasites and the Hygiene Hypothesis: Regulating the Immune System?

2004 • 425 citations

A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children

2000 • 415 citations

Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5

1994 • 395 citations

Dendritic Cells Are Required for the Development of Chronic Eosinophilic Airway Inflammation in Response to Inhaled Antigen in Sensitized Mice

1998 • 389 citations

The environmental predictors of allergic disease

2000 • 381 citations

Accelerated Migration of Respiratory Dendritic Cells to the Regional Lymph Nodes Is Limited to the Early Phase of Pulmonary Infection

2003 • 362 citations

Taking our breath away: dendritic cells in the pathogenesis of asthma

2003 • 340 citations

A Second-Generation Genomewide Screen for Asthma-Susceptibility Alleles in a Founder Population

2000 • 335 citations

To respond or not to respond: T cells in allergic asthma

2003 • 334 citations

Endotoxin exposure in allergy and asthma: Reconciling a paradox

2002 • 331 citations

Lymph node trafficking and antigen presentation by endobronchial eosinophils

2000 • 326 citations

Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways.

1991 • 316 citations

The pattern of atopic sensitization is associated with the development of asthma in childhood

2001 • 292 citations

Atopy and asthma: genetic variants of IL-4 and IL-13 signalling

2000 • 281 citations

Variation in the Interleukin 4–Receptor α Gene Confers Susceptibility to Asthma and Atopy in Ethnically Diverse Populations

2000 • 271 citations

Association of a Promoter Polymorphism of the CD14 Gene and Atopy

2001 • 270 citations

GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice.

1998 • 264 citations

Airway Epithelial Cells Release MIP-3α/CCL20 in Response to Cytokines and Ambient Particulate Matter

2003 • 258 citations

Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice

1997 • 257 citations

Characterization of a new subpopulation of mouse CD8α+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

2002 • 254 citations

Childhood risk factors for atopy and the importance of early intervention

2001 • 204 citations

A Restricted Subset of Dendritic Cells Captures Airborne Antigens and Remains Able to Activate Specific T Cells Long after Antigen Exposure

2002 • 204 citations

Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge

2001 • 204 citations

Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

2002 • 197 citations

Genetics of Atopy and Asthma: The Rationale behind Promoter-based Candidate Gene Studies (IL-4 and IL-10)

1997 • 197 citations

An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German Multicenter Atopy Study (MAS-90)

2000 • 196 citations

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma

2003 • 192 citations

Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids

1996 • 190 citations

Induction of Rapid T Cell Activation, Division, and Recirculation by Intratracheal Injection of Dendritic Cells in a TCR Transgenic Model

2000 • 185 citations

Th2 polarization by Der p 1–pulsed monocyte-derived dendritic cells is due to the allergic status of the donors

2001 • 185 citations

Prostaglandin D2 Inhibits Airway Dendritic Cell Migration and Function in Steady State Conditions by Selective Activation of the D Prostanoid Receptor 1

2003 • 184 citations

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ

2002 • 182 citations

A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma

2004 • 180 citations

Influenza Virus–induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein

2003 • 169 citations

Activation of Peroxisome Proliferator-Activated Receptor-γ in Dendritic Cells Inhibits the Development of Eosinophilic Airway Inflammation in a Mouse Model of Asthma

2004 • 167 citations

Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism

2001 • 166 citations

A Causative Relationship Exists Between Eosinophils and the Development of Allergic Pulmonary Pathologies in the Mouse

2003 • 163 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation

1999 • 157 citations

Matrix Metalloproteinase-9-Mediated Dendritic Cell Recruitment into the Airways Is a Critical Step in a Mouse Model of Asthma

2003 • 153 citations

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ

2002 • 150 citations

Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation

1999 • 149 citations

Importance of Genetic Factors in Adolescent Asthma

1998 • 142 citations

V75R576 IL-4 Receptor α Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function

2002 • 139 citations

Asthma and atopy – a total genome scan for susceptibility genes

2002 • 137 citations

Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31hiLy-6Cneg bone marrow precursors in a mouse model of asthma

2002 • 132 citations

Common Polymorphisms in the Coding Part of the IL4-Receptor Gene

1997 • 131 citations

No Evidence for Effects of Family Environment on Asthma

1997 • 127 citations

Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm

2000 • 118 citations

The −159 C→T polymorphism of CD14 is associated with nonatopic asthma and food allergy

2003 • 113 citations

Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation

2001 • 113 citations

Monocyte-Derived Dendritic Cells Induce a House Dust Mite-Specific Th2 Allergic Inflammation in the Lung of Humanized SCID Mice: Involvement of CCR7

2002 • 111 citations

Peroxisome Proliferator-Activated Receptor γ Inhibits the Migration of Dendritic Cells: Consequences for the Immune Response

2003 • 100 citations

Asthma in childhood

1983 • 99 citations

Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children

2003 • 98 citations

Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells

2003 • 95 citations

Activation of the D Prostanoid Receptor 1 Regulates Immune and Skin Allergic Responses

2004 • 90 citations

Airway Eosinophils Accumulate in the Mediastinal Lymph Nodes but Lack Antigen-Presenting Potential for Naive T Cells

2003 • 83 citations

Allergen-Induced Changes in Bone-Marrow Progenitor and Airway Dendritic Cells in Sensitized Rats

1999 • 82 citations

Analysis of the Life Cycle of Stat6

2002 • 72 citations

Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22.

2004 • 71 citations

Intratracheal Priming with Ovalbumin- and Ovalbumin 323–339 Peptide-Pulsed Dendritic Cells Induces Airway Hyperresponsiveness, Lung Eosinophilia, Goblet Cell Hyperplasia, and Inflammation

2001 • 69 citations

Sensitization to inhaled antigen by intratracheal instillation of dendritic cells

2000 • 67 citations

Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice

2000 • 62 citations

Cutting edge: effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction.

1999 • 60 citations

Conditional ablation of dendritic cells in transgenic mice.

1994 • 55 citations

Reconstitution of a Functional Human Type II IL-4/IL-13 Receptor in Mouse B Cells: Demonstration of Species Specificity

2001 • 52 citations

Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen‐presenting dendritic cell: influence of treatment with fluticasone propionate

1999 • 41 citations

Antigen‐presenting cells in nasal allergy

1999 • 27 citations