Role of Glutamate and Glutamate Receptors in Memory Function and Alzheimer's Disease^a

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

On the role of the hippocampus in learning and memory in the rat

1993 • 1,116 citations

Neurobiology of the hippocampus

1984 • 1,096 citations

Disorders of Learning and Memory after Temporal Lobe Lesions in Man

1972 • 878 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

1992 • 617 citations

Associations across time: The hippocampus as a temporary memory store

1985 • 563 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Glutamate receptor channels: novel properties and new clones

1992 • 427 citations

Glutamate decarboxylase in inhibitory neurons

1970 • 294 citations

Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[³H]Glutamate Binding

1987 • 281 citations

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats

1989 • 253 citations

Modulation of the Time Course of Fast EPSCs and Glutamate Channel Kinetics by Aniracetam

1991 • 242 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

Alzheimer's disease: Changes in hippocampal N-methyl-d-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors—an autoradiographic study

1990 • 195 citations

Memory Loss with Lesions of Hippocampal Formation

1961 • 194 citations

Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats

1978 • 187 citations

The Neuroanatomy of Alzheimer's Disease

1989 • 181 citations

Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?

1990 • 168 citations

Connections of the parahippocampal cortex. I. Cortical afferents

1986 • 158 citations

Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor

1992 • 154 citations

Experience, memory, and the brain.

1984 • 125 citations

Reduced Glycine Stimulation of [³H]MK‐801 Binding in Alzheimer's Disease

1989 • 117 citations

Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus

1991 • 113 citations

Modulation of memory processing by glutamic acid receptor agonists and antagonists

1990 • 111 citations

d-cycloserine attenuates scopolamine-induced learning and memory deficits in rats

1993 • 108 citations

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias.

1990 • 100 citations

D-Cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task

1992 • 94 citations

A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease.

1990 • 90 citations

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents

1989 • 90 citations

Effects of NMDA Modulation in Scopolamine Dementiaa

1991 • 87 citations

Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

1988 • 85 citations

Exploratory behavior and reaction to novelty in rats with hippocampal perforant path systems disrupted.

1988 • 80 citations

Exploratory behavior and reaction to novelty in rats with hippocampal perforant path systems disrupted.

1988 • 69 citations

Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats

1992 • 68 citations

d-Cycloserine, a modulator of the receptor, improves spatial learning in rats treated with muscarinic antagonist

1992 • 64 citations

d-Cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-d-aspartate receptor-ionophore complex in Alzheimer brain

1991 • 63 citations

Entorhinal-hippocampal interaction in mnestic disorders.

1993 • 61 citations

Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

1988 • 56 citations

Involvement of glycine site associated with the NMDA receptor in hippocampal long-term potentiation and acquisition of spatial memory in rats

1992 • 52 citations

[3H]MK-801 binding in Alzheimer's disease

1988 • 44 citations

Entorhinal—hippocampal interaction in mnestic disorders

1993 • 43 citations

Animal models of Alzheimer's disease: Glutamatergic denervation as an alternative approach to cholinergic denervation

1993 • 39 citations

Memory dysfunction following disruption of glutamergic systems in the temporal region of the rat: effects of agonistic amino acids

1992 • 38 citations

Perineuronal satellitosis in the human hippocampal formation

1993 • 38 citations

[³H]N‐[1‐(2‐Thienyl)cyclohexyl]‐3,4‐Piperidine ([³H]TCP) Binding in Human Frontal Cortex: Decreases in Alzheimer‐Type Dementia

1990 • 35 citations

The temporal–hippocampal region and retention: The role of temporo‐entorhinal connections in rats

1989 • 32 citations

Impaired reference memory and reduced glutamergic activity in rats with temporo-entorhinal connections disrupted

1989 • 27 citations

Differential rearing conditions in rats: Effects on neurochemistry in neocortical areas and cognitive behaviors

1992 • 25 citations

Failure of d-cycloserine to reverse cognitive disruption induced by scopolamine or phencylidine in primates

1992 • 23 citations

Restoration of mnemonic function in rats with glutamergic temporal systems disrupted: Dose and time of glycine injections

1993 • 12 citations

Changes in retention of a visual discrimination task following unilateral and bilateral transections of temporo-entorhinal connections in rats

1990 • 7 citations