Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans

The Biochemistry of Glycoproteins and Proteoglycans

1980 • 1,231 citations

Specificities of heparan sulphate proteoglycans in developmental processes

2000 • 706 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

The selectins and their ligands

1994 • 478 citations

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

1999 • 478 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

1998 • 453 citations

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

2000 • 433 citations

The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate

1998 • 425 citations

Heparin is essential for the storage of specific granule proteases in mast cells

1999 • 422 citations

Disruption of Gastrulation and Heparan Sulfate Biosynthesis in EXT1-Deficient Mice

2000 • 408 citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

1999 • 393 citations

Structure and Metabolism of Connective Tissue Proteoglycans

1980 • 381 citations

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

1998 • 377 citations

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

1999 • 367 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

A Receptor-like Protein-tyrosine Phosphatase PTPζ/RPTPβ Binds a Heparin-binding Growth Factor Midkine

1999 • 305 citations

Structural Analysis of Glycosaminoglycans inDrosophila and Caenorhabditis elegans and Demonstration That tout-velu, a Drosophila Gene Related to EXT Tumor Suppressors, Affects Heparan Sulfate in Vivo

2000 • 287 citations

The Elusive Functions of Proteoglycans

2000 • 258 citations

Defective Heparan Sulfate Biosynthesis and Neonatal Lethality in Mice LackingN-Deacetylase/N-Sulfotransferase-1

2000 • 239 citations

Cloning and Expression of a Proteoglycan UDP-Galactose:β-Xylose β1,4-Galactosyltransferase I

1999 • 227 citations

Involvement of Receptor-like Protein Tyrosine Phosphatase ζ/RPTPβ and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration

1998 • 219 citations

Spatially Restricted Expression of pipe in the Drosophila Egg Chamber Defines Embryonic Dorsal–Ventral Polarity

1998 • 208 citations

Influence of core protein sequence on glycosaminoglycan assembly

1996 • 204 citations

The Tumor Suppressor EXT-like Gene EXTL2 Encodes an α1, 4-N-Acetylhexosaminyltransferase That TransfersN-Acetylgalactosamine and N-Acetylglucosamine to the Common Glycosaminoglycan-Protein Linkage Region

1999 • 201 citations

High Affinity Binding and Overlapping Localization of Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β with Tenascin-R, Amphoterin, and the Heparin-binding Growth-associated Molecule

1998 • 189 citations

Heparan/Chondroitin Sulfate Biosynthesis

2000 • 188 citations

The DSD-1 Carbohydrate Epitope Depends on Sulfation, Correlates with Chondroitin Sulfate D Motifs, and Is Sufficient to Promote Neurite Outgrowth

1998 • 180 citations

Diversity and functions of glycosaminoglycan sulfotransferases

2000 • 172 citations

Molecular Cloning and Expression of Glucuronyltransferase I Involved in the Biosynthesis of the Glycosaminoglycan-Protein Linkage Region of Proteoglycans

1998 • 171 citations

Identification of a Receptor for Reg (Regenerating Gene) Protein, a Pancreatic β-Cell Regeneration Factor

2000 • 167 citations

Targeted disruption of NDST‐1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice

2000 • 166 citations

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis

2000 • 165 citations

Molecular Interactions of Neural Chondroitin Sulfate Proteoglycans in the Brain Development

2000 • 165 citations

Structural Analysis of Glycosaminoglycans in Animals Bearing Mutations in sugarless, sulfateless, andtout-velu

2000 • 156 citations

Molecular Basis for the Progeroid Variant of Ehlers-Danlos Syndrome

1999 • 155 citations

Characteristic Hexasaccharide Sequences in Octasaccharides Derived from Shark Cartilage Chondroitin Sulfate D with a Neurite Outgrowth Promoting Activity

1998 • 155 citations

Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan

1997 • 153 citations

Human Homolog of Caenorhabditis elegans sqv-3 Gene Is Galactosyltransferase I Involved in the Biosynthesis of the Glycosaminoglycan-Protein Linkage Region of Proteoglycans

1999 • 139 citations

Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

1999 • 127 citations

sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination

1999 • 127 citations

Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma. Demonstration of the structure Gal(4-O-sulfate)beta 1-3Gal beta 1-4XYL beta 1-O-Ser.

1988 • 123 citations

Chinese Hamster Ovary Cell Mutants Defective in Glycosaminoglycan Assembly and Glucuronosyltransferase I

1999 • 108 citations

Demonstration of glycosaminoglycans in Caenorhabditis elegans

1999 • 106 citations

Structural studies on sulfated oligosaccharides derived from the carbohydrate-protein linkage region of chondroitin 6-sulfate proteoglycans of shark cartilage. I. Six compounds containing 0 or 1 sulfate and/or phosphate residues.

1992 • 104 citations

Xylosylation is an endoplasmic reticulum to Golgi event

1993 • 103 citations

Location of the Glucuronosyltransferase Domain in the Heparan Sulfate Copolymerase EXT1 by Analysis of Chinese Hamster Ovary Cell Mutants

2000 • 88 citations

Identification and Molecular Cloning of a Chondroitin Synthase from Pasteurella multocida Type F

2000 • 79 citations

Structural studies on sulfated oligosaccharides derived from the carbohydrate-protein linkage region of chondroitin 6-sulfate proteoglycans of shark cartilage. II. Seven compounds containing 2 or 3 sulfate residues.

1992 • 76 citations

A Direct Interaction Between EXT Proteins and Glycosyltransferases is Defective in Hereditary Multiple Exostoses

1999 • 76 citations

Association of EXT1 and EXT2, Hereditary Multiple Exostoses Gene Products, in Golgi Apparatus

2000 • 76 citations

Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate

1985 • 73 citations

EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis

2000 • 68 citations

Identification of a Novel Glycosaminoglycan Core-like Molecule I

1995 • 64 citations

Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate.

1994 • 63 citations

Demonstration of the Immature Glycosaminoglycan Tetrasaccharide Sequence GlcAβ1–3Galβ1–3Galβ1–4Xyl on Recombinant Soluble Human α-Thrombomodulin

1998 • 60 citations

Regulation of chondroitin sulfate biosynthesis by specific sulfation: acceptor specificity of serum β-GalNAc transferase revealed by structurally defined oligosaccharides

1997 • 59 citations

Formation of HNK-1 Determinants and the Glycosaminoglycan Tetrasaccharide Linkage Region by UDP-GlcUA:Galactose β1,3-Glucuronosyltransferases

1999 • 53 citations

New perspectives on the molecular basis of hereditary bone tumours

1999 • 49 citations

Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan‐protein linkage region of proteoglycans

1999 • 49 citations

The Uniform Galactose 4‐Sulfate Structure in the Carbohydrate‐Protein Linkage Region of Human Urinary Trypsin Inhibitor

1995 • 45 citations

Characterization of serum β-glucuronyltransferase involved in chondroitin sulfate biosynthesis

1997 • 44 citations

N-Acetylgalactosamine (GalNAc) Transfer to the Common Carbohydrate-Protein Linkage Region of Sulfated Glycosaminoglycans

1995 • 42 citations

Cytoskeletal Abnormalities in Chondrocytes with EXT1 and EXT2 Mutations

2000 • 40 citations

Involvement of the core protein in the first β-N-acetylgalactosamine transfer to the glycosaminoglycan–protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesis

1999 • 26 citations

Identification and characterization of a novel UDP-GalNAc:GlcAbeta-R alpha1,4-N-acetylgalactosaminyltransferase from a human sarcoma cell line

1999 • 26 citations

Biosynthesis of Chondroitin Sulfate

1997 • 22 citations

Assessment of glycosaminoglycan-protein linkage tetrasaccharides as acceptors for GalNAc- and GlcNAc-transferases from mouse mastocytoma.

1997 • 21 citations

Purification and some properties of UDP-xylosyltransferase of rat ear cartilage

2000 • 21 citations

-N-Acetylgalactosamine-capping of chondroitin sulfate core region oligosaccharides primed on xylosides

1998 • 19 citations

Purification and characterization of fetal bovine serum β‐N‐acetyl‐D‐galactosaminyltransferase and β‐D‐glucuronyltransferase involved in chondroitin sulfate biosynthesis

1999 • 18 citations

Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma. Demonstration of the structure Gal(4-O-sulfate)β1-3Galβ1-4Xylβ1-O-Ser

1988 • 13 citations