Protein Kinase A Induces Phosphorylation of the Human 5-HT1A Receptor and Augments Its Desensitization by Protein Kinase C in CHO-K1 Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

1990 • 444 citations

Regulation of neurotransmitter receptor desensitization by protein phosphorylation

1990 • 439 citations

Multisite and hierarchal protein phosphorylation

1991 • 419 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

1994 • 371 citations

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

1992 • 327 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

Phosducin is a protein kinase A-regulated G-protein regulator

1992 • 233 citations

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

1987 • 206 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein .alpha.-subunits and lack of coupling to Gs.alpha.

1993 • 145 citations

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

1989 • 133 citations

Regulation of protein kinase C by sphingosine and lysosphingolipids

1989 • 101 citations

Production of specific anti-rat 5-HT1A receptor antibodies in rabbits injected with a synthetic peptide

1990 • 98 citations

Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.

1993 • 77 citations

The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins

1993 • 71 citations

The Human 5-HT1A Receptor Expressed in HeLa Cells Stimulates Sodium-dependent Phosphate Uptake via Protein Kinase C

1989 • 54 citations

Antipeptide antibodies against the 5-HT1A receptor

1992 • 51 citations

Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors.

1994 • 45 citations

Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells

1990 • 35 citations

Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin-releasing hormone desensitization is cell specific.

1994 • 33 citations

Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe.

1989 • 27 citations

Differential regulation by agonist and phorbol ester of cloned m1 and m2 muscarinic acetylcholine receptors in mouse Y1 adrenal cells and in Y1 cells deficient in cAMP-dependent protein kinase

1990 • 26 citations

Agonist-independent phosphorylation of purified cardiac muscarinic cholinergic receptors by protein kinase C

1990 • 25 citations

Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2.

1994 • 15 citations