The molecular basis of keloid and hypertrophic scar formation

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Transforming growth factor beta

2011 • 1,990 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

Morphological and immunochemical differences between keloid and hypertrophic scar.

1994 • 522 citations

Keloids and Hypertrophic Scars

1989 • 477 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

The Molecular and Cellular Biology of Wound Repair

1996 • 397 citations

The Effect of TGF-β on Keloid Fibroblast Proliferation and Collagen Synthesis

1996 • 289 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

In VitroFibroplasia: Matrix Contraction, Cell Growth, and Collagen Production of Fibroblasts Cultured in Fibrin Gels

1996 • 194 citations

Modulation of Collagen Synthesis by Transforming Growth Factor-β in Keloid and Hypertrophic Scar Fibroblasts

1994 • 189 citations

Intracellular signalling: The Mad way to do it

1996 • 162 citations

Keloids

1995 • 145 citations

Keloid Fibroblasts Exhibit an Altered Response to TGF-β

1992 • 132 citations

Rapid induction and clearance of TGFβ1 is an early response to wounding in the mouse embryo

1993 • 119 citations

Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids.

1996 • 115 citations

Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways.

1993 • 106 citations

Elevated Levels of Plasminogen Activator Inhibitor-1 May Account for the Altered Fibrinolysis by Keloid Fibroblasts

1996 • 91 citations

Fetal Wound Healing and the Development of Antiscarring Therapies for Adult Wound Healing

1988 • 81 citations

Role of Growth Factors in Scar Contraction

1996 • 74 citations

The 1996 Lindberg Award. Calcium antagonists alter cell shape and induce procollagenase synthesis in keloid and normal human dermal fibroblasts.

1996 • 62 citations

Role of platelet-derived growth factor in vivo

1996 • 61 citations

Wound Healing: Relationship of Wound Closing Tension to Scar Width in Rats

1990 • 59 citations

THE 1996 LINDBERG AWARD

1996 • 54 citations

Glucocorticoid Regulation of Elastin Synthesis in Human Fibroblasts: Down-Regulation in Fibroblasts from Normal Dermis But Not From Keloids

1995 • 52 citations

Keloid Excision and Recurrence Prophylaxis Via Intradermal Interferon‐Gamma Injections: A Pilot Study

1996 • 44 citations

Effect of Increased Tissue Traction Upon Tensile Strength of Cutaneous Incisions in Rats.

1966 • 42 citations

Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters. Altered response is accompanied by reduced sensitivity to prostaglandin E2 and altered down-regulation of phorbol ester binding sites.

1992 • 19 citations

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