Keloid Fibroblasts Exhibit an Altered Response to TGF-β

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

RNA POLYMERASE II

1991 • 729 citations

Characterization of a newly derived human sarcoma cell line (HT-1080)

1974 • 681 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing.

1988 • 559 citations

Fibronectins

1990 • 523 citations

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

1987 • 498 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Sequential appearance of fibronectin and collagen in experimental granulation tissue.

1980 • 449 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.

1988 • 418 citations

Fibronectin and wound healing

1984 • 379 citations

Biochemical Composition of the Connective Tissue in Keloids and Analysis of Collagen Metabolism in Keloid Fibroblast Cultures

1985 • 263 citations

HYPERTROPHIC SCARS AND KELOIDS A Collective Review

1974 • 260 citations

Distribution of fetal bovine serum fibronectin and endogenous rat cell fibronectin in extracellular matrix.

1979 • 244 citations

Scleroderma

1979 • 241 citations

Keloids: A review

1981 • 237 citations

Molecular mechanisms of transcriptional regulation in yeast

1990 • 224 citations

Deposition of plasma fibronectin in tissues.

1981 • 214 citations

Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts.

1985 • 208 citations

Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines.

1988 • 205 citations

Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro

1979 • 203 citations

Transforming growth factor β regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts

1988 • 185 citations

Differential effects of gamma-interferon on collagen and fibronectin gene expression.

1987 • 156 citations

Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing.

1989 • 156 citations

Evaluation of Transforming Growth Factor β and Type I Procollagen Gene Expression in Fibrotic Skin Disease by In Situ Hybridization

1990 • 155 citations

Increased collagen accumulation in dermal fibroblast cultures from patients with progressive systemic sclerosis (scleroderma).

1978 • 154 citations

Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal fibroblasts

1983 • 139 citations

Fibronectin involvement in granulation tissue and wound healing in rabbits.

1982 • 129 citations

Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth.

1988 • 122 citations

Fibronectin (FN) in hypertrophic scars and keloids

1983 • 98 citations

Cloning and analysis of the promotor region of the human fibronectin gene.

1987 • 97 citations

Hypertrophic scars and keloids: a review and new concept concerning their origin.

1982 • 90 citations

Differential Glucocorticoid Regulation of Collagen mRNAs in Human Dermal Fibroblasts

1989 • 80 citations

Increase in fibronectin in the deep dermis of involved skin in progressive systemic sclerosis

1979 • 77 citations

Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus.

1983 • 70 citations

Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts.

1988 • 65 citations

FIBRONECTIN IN EXPERIMENTAL GRANULATION TISSUE

1982 • 58 citations

Fibronectin in early phases of wound healing in children.

1981 • 49 citations

Quantitative assay of types I and III collagen synthesized by keloid biopsies and fibroblasts

1979 • 46 citations

Regulation of Collagen Gene Expression in Cutaneous Diseases With Dermal Fibrosis: Evidence for Pretranslational Control

1987 • 43 citations

The ultrastructure of a keloid

1980 • 41 citations

Dimethyl sulfoxide affects colony morphology on agar and alters distribution of glycosaminoglycans and fibronectin.

1982 • 20 citations