Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

1996 • 1,780 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

Functional role of estrogen metabolism in target cells: review and perspectives

1998 • 965 citations

Histaminergic transmission in the mammalian brain

1991 • 948 citations

Catecholamine metabolism: basic aspects and clinical significance.

1985 • 589 citations

Creatine: Biosynthesis, Regulation, and Function

1979 • 489 citations

Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism

1994 • 407 citations

Creatine kinase in non-muscle tissues and cells

1994 • 372 citations

Genomic organization of the human catechol O‐methyltransferase gene and its expression from two distinct promoters

1994 • 332 citations

Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility.

1999 • 299 citations

Mediators of immediate hypersensitivity

1983 • 293 citations

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

1997 • 286 citations

Creatine replacement therapy in guanidineoacetate methyltransferase deficiency, a novel inborn error of metabolism

1996 • 239 citations

The methylation of phosphatidylethanolamine

1988 • 238 citations

Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver

1993 • 232 citations

Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man.

1996 • 213 citations

Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.

1998 • 206 citations

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

1991 • 197 citations

Phosphatidylethanolamine N-methyltransferase from liver

1997 • 195 citations

Disruption of the murine gene encoding phosphatidylethanolamine N -methyltransferase

1997 • 156 citations

Human HistamineN-Methyltransferase Pharmacogenetics: Common Genetic Polymorphisms that Alter Activity

1998 • 134 citations

Molecular cloning and characterization of rat liver catechol-O-methyltransferase

1990 • 118 citations

Catechol-O-methyltransferase and breast cancer risk

1998 • 118 citations

Guanidino compounds in guanidinoacetate methyltransferase deficiency, a new inborn error of creatine synthesis

1997 • 106 citations

Expression and Intracellular Localization of Catechol O‐methyltransferase in Transfected Mammalian Cells

1997 • 103 citations

Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population

2000 • 96 citations

Molecular Mechanisms Controlling the Rate and Specificity of Catechol O-Methylation by Human Soluble Catechol O-Methyltransferase

2001 • 94 citations

Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma

2000 • 90 citations

Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.

1988 • 83 citations

Methyltransferase pharmacogenetics

1989 • 82 citations

Human liver nicotinamide N-methyltransferase: Ion-pairing radiochemical assay, biochemical properties and individual variation

1990 • 70 citations

Urinary Catecholamines in Attention-Deficit Hyperactivity Disorder with and without Comorbid Anxiety

1994 • 64 citations

Guanidinoacetate methyltransferase (GAMT) deficiency: non-invasive enzymatic diagnosis of a newly recognized inborn error of metabolism

2000 • 49 citations

Pharmacogenetics of N-methylation: Heritability of human erythrocyte histamine N-methyltransferase activity

1988 • 43 citations

Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene

2000 • 42 citations

Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population

2000 • 35 citations

Identification of 142 single nucleotide polymorphisms in 41 candidate genes for rheumatoid arthritis in the Japanese population

2000 • 34 citations

N-methylation of pyridines and Parkinson's disease.

1993 • 33 citations

Nicotinamide methylation in patients with cirrhosis

1994 • 33 citations

Two New Severe Mutations Causing Guanidinoacetate Methyltransferase Deficiency

2000 • 32 citations

A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol

1998 • 31 citations

Blunted Catecholamine Responses after Glucose Ingestion in Children with Attention Deficit Disorder

1995 • 29 citations

Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk.

2000 • 28 citations

Human nicotinamide N-methyltransferase pharmacogenetics

1999 • 27 citations

Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2

1999 • 24 citations

Genetic segregation analysis of red blood cell (RBC) histamine N‐methyltransferase (HNMT) activity

1993 • 22 citations

Histamine N-methyltransferase functional polymorphism: Lack of association with schizophrenia

2000 • 22 citations

Mucosal histamine elimination and its effect on acid secretion in rabbit gastric mucosa

1993 • 22 citations

Regulation of the adrenomedullary catecholaminergic system after mild, acute stress

1994 • 20 citations

Urinary epinephrine excretion during intelligence testing in attention-deficit hyperactivity disorder and normal boys

1996 • 18 citations

Two single nucleotide polymorphisms in the promoter region of the human phenylethanolamine N-methyltransferase PNMT gene

1999 • 15 citations

Identification of 142 single nucleotide polymorphisms in 41 candidate genes for rheumatoid arthritis in the Japanese population

2000 • 7 citations