Characterization of camptothecin-resistant chinese hamster lung cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: Bio-blots.

1983 • 1,075 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1989 • 445 citations

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

1981 • 350 citations

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

1989 • 338 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases

1981 • 231 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin

1971 • 213 citations

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells

1987 • 207 citations

Action of camptothecin on mammalian cells in culture.

1972 • 190 citations

A model for tumor cell killing by topoisomerase poisons.

1990 • 172 citations

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

1989 • 172 citations

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

1991 • 168 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Combined modalities of resistance in etoposide-resistant human KB cell lines.

1988 • 146 citations

Studies on camptothecin. I. Effects of nucleic acid and protein synthesis.

1971 • 146 citations

Effects of camptothecin on the breakage and repair of DNA during the cell cycle.

1973 • 140 citations

In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.

1978 • 135 citations

Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.

1990 • 133 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content.

1990 • 124 citations

DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: Comparisons to ataxia-telangiectasia cells

1990 • 93 citations

Camptothecin effects on DNA synthesis in murine leukemia cells

1972 • 87 citations

Six complementation groups for ionising-radiation sensitivity in Chinese hamster cells

1988 • 55 citations

Lethal activity of camptothecin sodium on human lymphoma cells.

1974 • 54 citations

Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.

1985 • 51 citations

Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.

1989 • 45 citations

Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants.

1991 • 39 citations

Expression of the topoisomerase I gene in serum stimulated human fibroblasts

1990 • 39 citations

Vector-mediated DNA double-strand break repair analysis in normal, and radiation-sensitive, Chinese hamster V79 cells

1988 • 37 citations

Development and cross-resistance characteristics of a subline of P388 leukemia resistant to 4′-(9-acridinylamino)-methanesulfon-m-anisidide

1982 • 29 citations

The effects of camptothecin on mammalian DNA

1973 • 14 citations