An inconvenient truth about obesity

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

2009 • 2,794 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus

2010 • 1,129 citations

The Need to Feed

2002 • 1,089 citations

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

2011 • 1,037 citations

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

2008 • 641 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

2009 • 428 citations

Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five-year perspective.

1989 • 426 citations

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight

2008 • 411 citations

The Energy Expenditure and Food Intake of Individual Men

1955 • 375 citations

Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus: Four-Year Results of the Look AHEAD Trial

2011 • 368 citations

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

2001 • 332 citations

Energy Density, Portion Size, and Eating Occasions: Contributions to Increased Energy Intake in the United States, 1977–2006

2011 • 276 citations

Energy intake in weight-reduced humans

2010 • 133 citations

Energy regulatory signals and food reward

2010 • 111 citations

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

2012 • 109 citations

Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective.

1991 • 89 citations

Corrective responses in human food intake identified from an analysis of 7-d food-intake records

2008 • 70 citations

Diet, Behavior Modification, and Exercise

1991 • 68 citations

Self-rated health does not predict 10-year weight change among middle-aged adults in a longitudinal population study

2011 • 38 citations