Substance P and its role in neural mechanisms governing learning, anxiety and functional recovery

Progress in Psychobiology and Physiological Psychology

2003 • 1,683 citations

Neurotransmitter functions of mammalian tachykinins.

1993 • 1,101 citations

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

1998 • 1,067 citations

The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments

1996 • 742 citations

The Mesolimbic Dopamine System: From Motivation to Action

1992 • 591 citations

The mesolimbic dopamine system : from motivation to action

1991 • 555 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms ¹

1990 • 449 citations

UNILATERAL 6-HYDROXYDOPAMINE LESIONS OF MESO-STRIATAL DOPAMINE NEURONS AND THEIR PHYSIOLOGICAL SEQUELAE

1996 • 348 citations

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

1999 • 282 citations

Neuropeptides: Regulators of Physiological Processes

1999 • 221 citations

The tachykinin NK1 receptor in the brain: pharmacology and putative functions

1999 • 207 citations

The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation

1997 • 204 citations

Substance P : metabolism and biological actions

1985 • 198 citations

Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain

1991 • 183 citations

Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice

1996 • 164 citations

The role of neuropeptides in learning: focus on the neurokinin substance P

1995 • 150 citations

Decrease of substance P-like immunoreactivity in the substantia nigra and pallidum of parkinsonian brains

1983 • 148 citations

Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat

1996 • 115 citations

Anxiolytic Action of a Neurokinin1 Receptor Antagonist in the Social Interaction Test

1997 • 112 citations

The relationship between reinforcement and memory: Parallels in the rewarding and mnemonic effects of the neuropeptide substance P

1989 • 103 citations

Short‐term restraint stress and s.c. saline injection alter the tissue levels of substance P and cholecystokinin in the peri‐aqueductal grey and limbic regions of rat brain

1992 • 91 citations

Effects of sequential removal of rats from a group cage, and of individual housing of rats, on substance P, cholecystokinin and somatostatin levels in the periaqueductal grey and limbic regions

1994 • 88 citations

Substance P in the ventral pallidum: Projection from the ventral striatum, and electrophysiological and behavioral cinsequences of pallidal substance P

1995 • 83 citations

Relationship between dopamine release in nucleus accumbens and place preference induced by substance P injected into the nucleus basalis magnocellularis region

1995 • 80 citations

Effects of substance P on extracellular dopamine in neostriatum and nucleus accumbens

1992 • 68 citations

Ventral pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward-related brain regions

1997 • 66 citations

Anxiolytic-like action of neurokinin substance P administered systemically or into the nucleus basalis magnocellularis region

1998 • 65 citations

Pharmacological Characterization of Tachykinin Receptors Controlling Acetylcholine Release from Rat Striatum: An In Vivo Microdialysis Study

1995 • 61 citations

Recovery from unilateral 6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin substance P1–11

1992 • 60 citations

Anxiogenic effects of substance P and its 7–11 C terminal, but not the 1–7 N terminal, injected into the dorsal periaqueductal gray☆

1999 • 53 citations

Reinforcing effects of neurokinin substance P in the ventral pallidum: mediation by the tachykinin NK1 receptor

1999 • 52 citations

Possible Role(s) of Neurokinins in CNS Development and Neurodegenerative or Other Disorders

1998 • 47 citations

Substance P decreases extracellular concentrations of acetylcholine in neostriatum and nucleus accumbens in vivo: Possible relevance for the central processing of reward and aversion

1994 • 45 citations

Modulation of memory retention by neuropeptide K

1990 • 45 citations

Neuropeptides

1998 • 44 citations

The C-terminal fragment of substance P enhances dopamine release in nucleus accumbens but not in neostriatum in freely moving rats

1992 • 41 citations

Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine

1995 • 41 citations

Aversive effects of the C-fragment of Substance P in the dorsal periaqueductal gray matter

1998 • 40 citations

Differential modulation of frontal cortex acetylcholine by injection of substance P into the nucleus basalis magnocellularis region in the freely-moving vs. the anesthetized preparation

2000 • 36 citations

Neuropeptide substance P improves water maze performance in aged rats

1990 • 35 citations

Chronic administration of neurokinin SP improves maze performance in aged Rattus norvegicus

1994 • 34 citations

In Vivo Neurochemical Correlates of Cognitive Processes: Methodological and Conceptual Challenges

1999 • 34 citations

Tachykinins, Neurotrophism and Neurodegenerative Diseases: A Critical Review on the Possible Role of Tachykinins in the Aetiology of CNS Diseases

1996 • 31 citations

Influence of substance P and fragments on passive avoidance behavior

1984 • 31 citations

Pretreatment With Neurokinin Substance P But Not With Cholecystokinin-8S Can Alleviate Functional Deficits of Partial Nigrostriatal 6-Hydroxydopamine Lesion

1997 • 30 citations

Anxiolytic-like effects in rats produced by ventral pallidal injection of both N- and C-terminal fragments of substance P

2000 • 29 citations

Both extracellular and transmembrane residues contribute to the species selectivity of the neurokinin-1 receptor antagonist WIN 51708.

1994 • 28 citations

The neurokinin-1 receptor antagonist WIN51,708 attenuates the anxiolyticlike effects of ventralpallidal substance P injection

1999 • 24 citations

Pretreatment With Fragments of Substance-P or With Cholecystokinin Differentially Affects Recovery From Sub-Total Nigrostriatal 6-Hydroxydopamine Lesion

1999 • 13 citations

Brain substance P receptors in Parkinson's disease.

1990 • 13 citations

Interactions between themu opioid agonist DAMGO and substance P in regulation of the ventral pallidum

1996 • 12 citations

Trophic Regulation of the Basal Ganglia

1994 • 9 citations

Acidic and Basic Fibroblast Growth Factors are Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons

1994 • 3 citations

Deleted Work

1955 • 0 citations