Evidence for Calcineurin-mediated Regulation of SERCA 2a Activity in Human Myocardium

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate

1971 • 1,736 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

1992 • 656 citations

Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin.

1987 • 489 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum

1989 • 449 citations

Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.

1975 • 431 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

Molecular mechanisms of theprotein serine/threonine phosphatases

1996 • 365 citations

Identification and Expression of δ-Isoforms of the Multifunctional Ca ²⁺ /Calmodulin-Dependent Protein Kinase in Failing and Nonfailing Human Myocardium

1999 • 311 citations

Phospholamban Phosphorylation in Intact Ventricles

1989 • 289 citations

Reduced Ca2+-Sensitivity of SERCA 2a in Failing Human Myocardium due to Reduced Serin-16 Phospholamban Phoshorylation

1999 • 282 citations

Increased Expression of Cardiac Phosphatases in Patients with End-stage Heart Failure

1997 • 262 citations

Phosphorylation-induced mobility shift in phospholamban in sodium dodecyl sulfate-polyacrylamide gels. Evidence for a protein structure consisting of multiple identical phosphorylatable subunits.

1984 • 254 citations

Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts

1999 • 243 citations

Calcineurin and Beyond

2000 • 227 citations

Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy

1987 • 207 citations

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

2001 • 202 citations

Phosphorylation and activation of the Ca(2+)-pumping ATPase of cardiac sarcoplasmic reticulum by Ca2+/calmodulin-dependent protein kinase.

1993 • 163 citations

Calcium Content of the Sarcoplasmic Reticulum in Isolated Ventricular Myocytes from Patients with Terminal Heart Failure

1998 • 163 citations

Phospholamban Regulates the Ca2+-ATPase through Intramembrane Interactions

1996 • 139 citations

Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase

1994 • 136 citations

Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart.

1993 • 125 citations

The max of the Ca2+-ATPase of Cardiac Sarcoplasmic Reticulum (SERCA2a) Is Not Altered by Ca2+/Calmodulin-dependent Phosphorylation or by Interaction with Phospholamban

1996 • 124 citations

Evidence for isoproterenol-induced phosphorylation of phosphatase inhibitor-1 in the intact heart.

1991 • 115 citations

Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca2+-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles

1993 • 107 citations

Purified, Reconstituted Cardiac Ca2+-ATPase Is Regulated by Phospholamban but Not by Direct Phosphorylation with Ca2+/Calmodulin-dependent Protein Kinase

1996 • 106 citations

Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid

1993 • 106 citations

Diminished Basal Phosphorylation Level of Phospholamban in the Postinfarction Remodeled Rat Ventricle

1999 • 103 citations

Discrimination between two sites of phosphorylation on adjacent amino acids by phosphorylation site-specific antibodies to phospholamban.

1994 • 98 citations

Ser¹⁶prevails over Thr¹⁷phospholamban phosphorylation in the β-adrenergic regulation of cardiac relaxation

1999 • 79 citations

On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor.

1995 • 59 citations

Calcineurin inhibition and cardiac hypertrophy: A matter of balance

2001 • 59 citations

Phosphorylation and regulation of the Ca2+-pumping ATPase in cardiac sarcoplasmic reticulum by calcium/calmodulin-dependent protein kinase

1997 • 55 citations

Sites of Selective cAMP-dependent Phosphorylation of the L-type Calcium Channel α1 Subunit from Intact Rabbit Skeletal Muscle Myotubes

1995 • 53 citations

Ca2+/Calmodulin-Dependent Phosphorylation of the Ca2+-ATPase, Uncoupled from Phospholamban, Stimulates Ca2+-Pumping in Native Cardiac Sarcoplasmic Reticulum

1999 • 52 citations

Calcium sequestration by the sarcoplasmic reticulum in heart failure

1998 • 49 citations

Unchanged protein expression of sarcoplasmic reticulum Ca 2+ -ATPase, phospholamban, and calsequestrin in terminally failing human myocardium

1998 • 37 citations

Cyclic GMP-Mediated Phospholamban Phosphorylation in Intact Cardiomyocytes

1995 • 35 citations

Calcineurin—the missing link in cardiac hypertrophy

1998 • 32 citations

Reversible Inhibition of the Calcium-pumping ATPase in Native Cardiac Sarcoplasmic Reticulum by a Calmodulin-binding Peptide

2000 • 27 citations

Phosphorylation of cardiac junctional and free sarcoplasmic reticulum by PKC?, PKC?, PKA and the Ca2+/calmodulin-dependent protein kinase

1996 • 24 citations

SERCA2a activity correlates with the force-frequency relationship in human myocardium

2000 • 23 citations

Isoform expression of the sarcoplasmic reticulum Ca2+ release channel (ryanodine channel) in human myocardium

2000 • 18 citations