Systematic characterization of human CD8⁺ T cells with natural killer cell markers in comparison with natural killer cells and normal CD8⁺ T cells

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).

1981 • 1,411 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.

1986 • 1,106 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1

1984 • 723 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

1998 • 649 citations

A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

1996 • 534 citations

Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.

1989 • 492 citations

CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells

1998 • 445 citations

A potential role for interleukin-15 in the regulation of human natural killer cell survival.

1997 • 413 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Innate and adaptive lymphoid cells in the human liver

2000 • 396 citations

Perforin: structure and function

1995 • 361 citations

The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses

2000 • 339 citations

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression

2000 • 263 citations

Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

2000 • 256 citations

Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.

1995 • 222 citations

Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by α-Galactosylceramide in Mice

2001 • 217 citations

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

1995 • 194 citations

Decrease of CD56+T Cells and Natural Killer Cells in Cirrhotic Livers With Hepatitis C May Be Involved in Their Susceptibility to Hepatocellular Carcinoma

2000 • 191 citations

Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis.

1996 • 175 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset.

1995 • 162 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.

1997 • 159 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Physiological responses of extrathymic T cells in the liver

2000 • 129 citations

Mouse liver T cells: Their change with aging and in comparison with peripheral T cells

1997 • 126 citations

Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction.

1998 • 126 citations

c-kit+ stem cells and thymocyte precursors in the livers of adult mice.

1996 • 121 citations

Cytotoxic gammadelta or alphabeta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2.

1996 • 121 citations

Involvement of NK1+ T Cells and Their IFN-γ Production in the Generalized Shwartzman Reaction

1998 • 105 citations

Persistence of T8+/HNK-1+ suppressor lymphocytes in the blood of long-term surviving patients after allogeneic bone marrow transplantation.

1986 • 105 citations

Diminished Calcium Signal Generation in Subsets of T Lymphocytes That Predominate in Old Mice

1990 • 89 citations

Chairman's Summary

1990 • 82 citations

Numerical and functional characteristics of lymphocyte subsets in centenarians.

1997 • 77 citations

IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation.

1998 • 75 citations

CD8+NKR-P1A+ T cells preferentially accumulate in human liver

1999 • 75 citations

Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subset

1989 • 73 citations

Extrathymic Pathways of T-cell Differentiation in the Liver and Other Organs

1994 • 68 citations

An inhibitor of cytotoxic functions produced by CD8⁺CD57⁺ T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients

1994 • 65 citations

CD57+/CD28− T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile, ex vivo cytolytic activity and enhanced tendency to apoptosis

1998 • 63 citations

Increased percentage of cd3+, cd57+ lymphocytes in patients with rheumatoid arthritis. correlation with duration of disease

1993 • 58 citations

IL-15 Promotes IL-12 Production by Human Monocytes Via T Cell-Dependent Contact and May Contribute to IL-12-Mediated IFN-γ Secretion by CD4+ T Cells in the Absence of TCR Ligation

1998 • 51 citations

HNK-1+ (Leu-7) and other lymphocyte subsets in long-term survivors with renal allotransplants.

1985 • 40 citations

Mouse CD8+ CD122+ T Cells with Intermediate TCR Increasing with Age Provide a Source of Early IFN-γ Production

2000 • 38 citations

Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti-inflammatory role

1998 • 38 citations

Lectin-induced cytotoxic activity in spleen cells from young and old mice. Age-related changes in types of effector cells, lymphokine production and response.

1988 • 31 citations

Analysis of mechanisms by which NK cells acquire increased cytotoxicity against class I MHC-eliminated targets

1989 • 26 citations