Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

2005 • 2,741 citations

Antibody neutralization and escape by HIV-1

2003 • 2,384 citations

Complete Replication of Hepatitis C Virus in Cell Culture

2005 • 2,239 citations

Binding of Hepatitis C Virus to CD81

1998 • 2,042 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Robust hepatitis C virus infectionin vitro

2005 • 1,691 citations

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

2007 • 1,182 citations

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

2002 • 1,152 citations

Virus Entry: Open Sesame

2006 • 1,136 citations

Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes

2003 • 1,093 citations

Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection

2009 • 1,025 citations

Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor

1999 • 947 citations

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

2010 • 926 citations

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

2009 • 901 citations

DC-SIGN: escape mechanism for pathogens

2003 • 898 citations

Hepatitis C virus replication in mice with chimeric human livers

2001 • 870 citations

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

2003 • 792 citations

How Viruses Enter Animal Cells

2004 • 726 citations

Structural biology of hepatitis C virus

2004 • 667 citations

Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the SR-B1 Scavenger Receptor

2003 • 607 citations

Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development

1997 • 593 citations

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

2007 • 580 citations

Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis

2006 • 563 citations

Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

2007 • 542 citations

Resistance to Direct Antiviral Agents in Patients With Hepatitis C Virus Infection

2009 • 516 citations

Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins

2007 • 515 citations

Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate

2003 • 476 citations

Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81

1999 • 470 citations

Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion

2007 • 441 citations

Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses

2006 • 406 citations

Human Apolipoprotein E Is Required for Infectivity and Production of Hepatitis C Virus in Cell Culture

2007 • 405 citations

Arbidol: A Broad-Spectrum Antiviral Compound that Blocks Viral Fusion

2008 • 397 citations

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems

2001 • 389 citations

Hepatitis C Virus Structural Proteins Assemble into Viruslike Particles in Insect Cells

1998 • 382 citations

Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR

2003 • 382 citations

Hepatitis C and liver transplantation

2005 • 375 citations

Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies

2007 • 370 citations

Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

2006 • 370 citations

Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes

1993 • 363 citations

Association of hepatitis C virus in human sera with ?-lipoprotein

1992 • 358 citations

CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection

2004 • 354 citations

A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.

1996 • 347 citations

Spontaneous Control of Primary Hepatitis C Virus Infection and Immunity Against Persistent Reinfection

2009 • 341 citations

Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

2008 • 340 citations

Association between Hepatitis C Virus and Very-Low-Density Lipoprotein (VLDL)/LDL Analyzed in Iodixanol Density Gradients

2006 • 335 citations

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

2010 • 326 citations

L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus

2003 • 296 citations

Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles

2006 • 291 citations

CD81 is an entry coreceptor for hepatitis C virus

2004 • 284 citations

An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies

2005 • 283 citations

Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope Glycoprotein

2005 • 280 citations

The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus

2006 • 279 citations

Human Serum Facilitates Hepatitis C Virus Infection, and Neutralizing Responses Inversely Correlate with Viral Replication Kinetics at the Acute Phase of Hepatitis C Virus Infection

2005 • 271 citations

Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Glycoproteins

2005 • 269 citations

Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus

2005 • 262 citations

Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding

2006 • 255 citations

Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81

2007 • 246 citations

High Density Lipoproteins Facilitate Hepatitis C Virus Entry through the Scavenger Receptor Class B Type I

2005 • 245 citations

Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin

2007 • 240 citations

Antibodies in Human Sera Specific to Hypervariable Region 1 of Hepatitis C Virus Can Block Viral Attachment

1995 • 227 citations

Selection Pressure From Neutralizing Antibodies Drives Sequence Evolution During Acute Infection With Hepatitis C Virus

2009 • 227 citations

Characterization of Hepatitis C Virus (HCV) and HCV E2 Interactions with CD81 and the Low-Density Lipoprotein Receptor

2000 • 224 citations

Multiple effects of silymarin on the hepatitis C virus lifecycle

2010 • 222 citations

Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo

2008 • 219 citations

Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles

2009 • 216 citations

Claudin-6 and Claudin-9 Function as Additional Coreceptors for Hepatitis C Virus

2007 • 216 citations

Claudin Association with CD81 Defines Hepatitis C Virus Entry

2010 • 215 citations

Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes

2010 • 211 citations

A model for the hepatitis C virus envelope glycoprotein E2

2000 • 209 citations

The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein

2007 • 208 citations

CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry

2008 • 200 citations

The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus

2008 • 200 citations

Characterization of the Envelope Glycoproteins Associated with Infectious Hepatitis C Virus

2010 • 197 citations

C-type Lectins L-SIGN and DC-SIGN Capture and Transmit Infectious Hepatitis C Virus Pseudotype Particles

2004 • 194 citations

Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2

2001 • 186 citations

Viral and Cellular Determinants of the Hepatitis C Virus Envelope-Heparan SulfateInteraction

2006 • 184 citations

CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells

2008 • 182 citations

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin

2003 • 180 citations

Serum Amyloid A Binding to CLA-1 (CD36 and LIMPII Analogous-1) Mediates Serum Amyloid A Protein-induced Activation of ERK1/2 and p38 Mitogen-activated Protein Kinases

2004 • 178 citations

Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus

2007 • 175 citations

Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations

2009 • 173 citations

RNA Interference and Single Particle Tracking Analysis of Hepatitis C Virus Endocytosis

2009 • 173 citations

Diverse Hepatitis C Virus Glycoproteins Mediate Viral Infection in a CD81-Dependent Manner

2004 • 172 citations

Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses

2005 • 172 citations

Isolation and Characterization of Broadly Neutralizing Human Monoclonal Antibodies to the E1 Glycoprotein of Hepatitis C Virus

2007 • 172 citations

Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus

2009 • 172 citations

A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipients

2005 • 171 citations

Cyanovirin-N Inhibits Hepatitis C Virus Entry by Binding to Envelope Protein Glycans

2006 • 170 citations

Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants

2009 • 166 citations

Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies

2008 • 166 citations

Serum Amyloid A Is a Ligand for Scavenger Receptor Class B Type I and Inhibits High Density Lipoprotein Binding and Selective Lipid Uptake

2004 • 164 citations

Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes

2010 • 162 citations

The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection

2009 • 157 citations

High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein

2007 • 151 citations

The interaction of natural hepatitis C virus with human scavenger receptor SR‐BI/Cla1 is mediated by ApoB‐containing lipoproteins

2006 • 150 citations

Analysis of Antigenicity and Topology of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles

2002 • 149 citations

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening

2009 • 144 citations

Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors

2010 • 140 citations

Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus

2007 • 139 citations

Analysis of Antigenicity and Topology of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles

2002 • 136 citations

Hepatitis C Virus Glycoproteins Mediate Low pH-dependent Membrane Fusion with Liposomes

2005 • 136 citations

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

2010 • 136 citations

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver–chimeric mice from infection with a homologous hepatitis C virus strain

2008 • 135 citations

Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells

2006 • 129 citations

Identification of a Broadly Cross-Reacting and Neutralizing Human Monoclonal Antibody Directed against the Hepatitis C Virus E2 Protein

2007 • 125 citations

Polarization Restricts Hepatitis C Virus Entry into HepG2 Hepatoma Cells

2009 • 124 citations

Monoclonal antibody HCV-AbXTL68 in patients undergoing liver transplantation for HCV: Results of a phase 2 randomized study

2006 • 123 citations

Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains

2009 • 121 citations

Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies

2008 • 119 citations

Enfuvirtide, the first fusion inhibitor to treat HIV infection.

2005 • 114 citations

Preclinical Evaluation of Two Neutralizing Human Monoclonal Antibodies against Hepatitis C Virus (HCV): a Potential Treatment To Prevent HCV Reinfection in Liver Transplant Patients

2006 • 106 citations

Hepatitis C virus receptor expression in normal and diseased liver tissue

2007 • 105 citations

Correlation of the Tight Junction-like Distribution of Claudin-1 to the Cellular Tropism of Hepatitis C Virus

2008 • 105 citations

Carbohydrate-Binding Agents: A Potential Future Cornerstone for the Chemotherapy of Enveloped Viruses?

2007 • 101 citations

Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity

2009 • 100 citations

Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2

2005 • 99 citations

Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity

2008 • 97 citations

Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells

2008 • 94 citations

Serum amyloid A has antiviral activity against hepatitis C virus by inhibiting virus entry in a cell culture system

2006 • 90 citations

Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle Entry

2006 • 89 citations

Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins.

2001 • 88 citations

Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection

2006 • 88 citations

Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles

2009 • 87 citations

Experimental models for hepatitis C viral infection

2009 • 85 citations

Functional hepatitis C virus envelope glycoproteins

2004 • 85 citations

Transmembrane Domains of Hepatitis C Virus Envelope Glycoproteins: Residues Involved in E1E2 Heterodimerization and Involvement of These Domains in Virus Entry

2006 • 84 citations

Entry of hepatitis C virus pseudotypes into primary human hepatocytes by clathrin-dependent endocytosis

2006 • 82 citations

Construction and characterization of chimeric hepatitis C virus E2 glycoproteins: analysis of regions critical for glycoprotein aggregation and CD81 binding

2000 • 82 citations

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

2008 • 81 citations

Glucocorticosteroids Increase Cell Entry by Hepatitis C Virus

2010 • 80 citations

Neutralizing Host Responses in Hepatitis C Virus Infection Target Viral Entry at Postbinding Steps and Membrane Fusion

2008 • 77 citations

Residues in a Highly Conserved Claudin-1 Motif Are Required for Hepatitis C Virus Entry and Mediate the Formation of Cell-Cell Contacts

2009 • 77 citations

Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry

2009 • 76 citations

Acceleration of Hepatitis C Virus Envelope Evolution in Humans Is Consistent with Progressive Humoral Immune Selection during the Transition from Acute to Chronic Infection

2010 • 73 citations

Phosphorothioate Oligonucleotides Inhibit Human Immunodeficiency Virus Type 1 Fusion by Blocking gp41 Core Formation

2006 • 68 citations

Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies

2010 • 66 citations

Small molecule inhibition of hepatitis C virus E2 binding to CD81

2003 • 64 citations

New and experimental therapies for HCV

2009 • 59 citations

Host neutralizing responses and pathogenesis of hepatitis C virus infection

2008 • 53 citations

Mouse models for the study of HCV infection and virus–host interactions

2008 • 50 citations

Neutralizing antibodies in hepatitis C virus infection

2007 • 50 citations

Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy

2009 • 46 citations

Functional Analysis of Hepatitis C Virus Envelope Proteins, Using a Cell-Cell Fusion Assay

2006 • 45 citations

The entry machinery of flaviviruses

2004 • 45 citations

Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus Internalization

2009 • 44 citations

RNAi as a new therapeutic strategy against HCV

2009 • 32 citations

Therapeutic Control of Hepatitis C Virus: The Role of Neutralizing Monoclonal Antibodies

2007 • 23 citations

Liver transplantation in viral hepatitis: Prevention of recurrence

2008 • 20 citations

The entry machinery of ftaviviruses

2011 • 7 citations

HepeX-C (XTL Biopharmaceuticals).

2004 • 6 citations

Tight junctions and viral entry

2010 • 3 citations